Cited by 205RNA Interference and Gene DeliveryMonoclonal and Polyclonal Antibodies ResearchRNA and protein synthesis mechanisms

How mRNA therapeutics are entering the monoclonal antibody field

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Van Hoecke, Lien, Roose, Kenny·2019·Journal of Translational Medicine

Abstract

In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branch of biomedical research. Antibodies are now used as frontline therapeutics in highly divergent indications, ranging from autoimmune disease over allergic asthma to cancer. Wider accessibility and implementation of antibody-based therapeutics is however hindered by manufacturing challenges and high development costs inherent to protein-based drugs. For these reasons, alternative ways are being pursued to produce and deliver antibodies more cost-effectively without hampering safety. Over the past decade, messenger RNA (mRNA) based drugs have emerged as a highly appealing new class of biologics that can be used to encode any protein of interest directly in vivo. Whereas current clinical efforts to use mRNA as a drug are mainly situated at the level of prophylactic and therapeutic vaccination, three recent preclinical studies have addressed the feasibility of using mRNA to encode therapeutic antibodies directly in vivo. Here, we highlight the potential of mRNA-based approaches to solve several of the issues associated with antibodies produced and delivered in protein format. Nonetheless, we also identify key hurdles that mRNA-based approaches still need to take to fulfill this potential and ultimately replace the current protein antibody format.

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Authors
Van Hoecke, L., & Roose, K.
Affiliations
Ghent University (BE)
Venue
Journal of Translational Medicine
Published
2019-02-22
Volume
17
Issue
1
Pages
54-54
ISSN
1479-5876 (ISSN-L)
OpenAlex
W2947249571
Cited by
205
References
107
Citations by year
2026: 22 · 2025: 27 · 2024: 42 · 2023: 33 · 2022: 32 · 2021: 33 · 2020: 14 · 2019: 2
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • Journal of Translational Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Vlaams Instituut voor Biotechnologie
  • Vlaamse regering
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
mRNA therapeutics, therapeutic antibodies, hybridoma, monoclonal antibodies, protein-based drugs, drug development costs, prophylactic and therapeutic vaccination
MeSH terms
Animals, Antibodies, Monoclonal, Humans, Models, Biological, RNA, Messenger, Gene Transfer Techniques, Bioreactors

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