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Cited by 397

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance

Monzillo, Lais U., Hamdy, Osama, Horton, Edward S., Ledbury, Sarah, Mullooly, Cathy, Jarema, Catherine, Porter, Satoko, Ovalle, Kerry, Moussa, Amr, Mantzoros, Christos S.·2003·Obesity Research
DOI 10.1038/oby.2003.144
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Abstract

Objective: To study the effect of weight loss in response to a lifestyle modification program on the circulating levels of adipose tissue derived cytokines (adipokines) in obese individuals with insulin resistance. Research Methods and Procedures: Twenty‐four insulin‐resistant obese subjects with varying degrees of glucose tolerance completed a 6‐month program consisting of combined hypocaloric diet and moderate physical activity. Adipokines [leptin, adiponectin, resistin, tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6)] and highly sensitive C‐reactive protein were measured before and after the intervention. Insulin sensitivity index was evaluated by the frequently sampled intravenous glucose tolerance test. Results: Participants had a 6.9 ± 0.1 kg average weight loss, with a significant improvement in sensitivity index and reduction in plasma leptin (27.8 ± 3 vs. 23.6 ± 3 ng/mL, p = 0.01) and IL‐6 (2.75 ± 1.51 vs. 2.3 ± 0.91 pg/mL, p = 0.012). TNF‐α levels tended to decrease (2.3 ± 0.2 vs. 1.9 ± 0.1 pg/mL, p = 0.059). Adiponectin increased significantly only among diabetic subjects. The reductions in leptin were correlated with the decreases in BMI (r = 0.464, p < 0.05) and with changes in highly sensitive C‐reactive protein (r = 0.466, p < 0.05). Discussion: Weight reduction in obese individuals with insulin resistance was associated with a significant decrease in leptin and IL‐6 and a tendency toward a decrease in circulating TNF‐α, whereas adiponectin was increased only in diabetic subjects. Further studies are needed to elucidate the relationship between changes of adipokines and the health benefits of weight loss.

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Metadata

Authors
Monzillo, L. U., Hamdy, O., Horton, E. S., Ledbury, S., Mullooly, C., Jarema, C., Porter, S., Ovalle, K., Moussa, A., & Mantzoros, C. S.
Venue
Obesity Research
Publisher
Wiley
Published
2003-09
Volume
11
Issue
9
Pages
1048-1054
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2003.144
OpenAlex
W2046387295
Cited by
397
References
32
FWCI
18.16
Type
journal article
Language
en
Open access
closed

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