Cited by 49Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsLipid metabolism and biosynthesis

Effects of IL-15 on rat brown adipose tissue: Uncoupling proteins and PPARs

Almendro, Vanessa, Fuster, Gemma, Busquets, Sílvia, Ametller, Elisabet, Figueras, Maite, Argilés, Josep M., López‐Soriano, Francisco J.·2008·Obesity

Abstract

OBJECTIVES: Interleukin-15 (IL-15) plays an important role in lipid metabolism as its administration to rats causes a marked depletion of white adipose tissue (WAT). This reduction in fat mass seems to be caused by and related to hipotriglyceridemia as a result of a lower hepatic lipogenesis and an increased fatty acid oxidation. We have previously observed that IL-15 treatment induces the expression of uncoupling proteins (UCPs) in muscle. The aim of this study was to investigate the effects of IL-15 on brown adipose tissue (BAT), and in particular on genes related to lipid metabolism in this tissue. METHODS AND PROCEDURES: Male Wistar rats were treated daily with IL-15 for 7 days. Adipose tissues were collected and the mRNA content of UCPs, peroxisome proliferator-activated receptors (PPARs) and several genes implicated in fatty acid transport and oxidation were evaluated on BAT. RESULTS: IL-15 treatment in rats causes a decrease in the mass of both WAT and BAT (35 and 24%, respectively). In BAT, an important upregulation of the mRNA content of thermogenic proteins (UCP1 and UCP3), lipid-related transcription factors (PPARdelta and PPARalpha) and other proteins implicated in membrane transport (fatty acid translocase (FAT) and fatty acid transport protein (FATP)), mitochondrial transport (carnitine palmitoyl transferase-I (CPT-I) and CPT-II) and consumption (acyl-CoA synthetase 4 (ACS4)) of fatty acids was observed as a consequence of the treatment. DISCUSSION: The changes observed in BAT suggest that IL-15 could be implicated in lipid consumption in this tissue by regulating lipid oxidation and probably thermogenesis, processes mediated by UCPs and PPARs.

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Crossref · 10.1038/oby.2007.47

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Authors
Almendro, V., Fuster, G., Busquets, S., Ametller, E., Figueras, M., Argilés, J. M., & López‐Soriano, F. J.
Affiliations
Universitat de Barcelona (ES)
Venue
Obesity
Publisher
Wiley
Published
2008-02
Volume
16
Issue
2
Pages
285-289
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W1992771950
Cited by
49
References
34
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
Dirección General de Investigación Científica y Técnica
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
IL-15, brown adipose tissue, uncoupling proteins, UCP1, UCP3, peroxisome proliferator-activated receptors, PPARδ, PPARα, fatty acid oxidation, thermogenesis, fatty acid uptake, carnitine palmitoyltransferase, lipid metabolism
MeSH terms
Uncoupling Protein 3, Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Fatty Acids, Ion Channels, Male, Oxidation-Reduction, RNA, Messenger, Rats, Wistar, Interleukin-15, Thermogenesis, Mitochondrial Proteins, PPAR alpha, PPAR delta, Lipid Metabolism, Rats

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