Effects of IL-15 on rat brown adipose tissue: Uncoupling proteins and PPARs
Abstract
OBJECTIVES: Interleukin-15 (IL-15) plays an important role in lipid metabolism as its administration to rats causes a marked depletion of white adipose tissue (WAT). This reduction in fat mass seems to be caused by and related to hipotriglyceridemia as a result of a lower hepatic lipogenesis and an increased fatty acid oxidation. We have previously observed that IL-15 treatment induces the expression of uncoupling proteins (UCPs) in muscle. The aim of this study was to investigate the effects of IL-15 on brown adipose tissue (BAT), and in particular on genes related to lipid metabolism in this tissue. METHODS AND PROCEDURES: Male Wistar rats were treated daily with IL-15 for 7 days. Adipose tissues were collected and the mRNA content of UCPs, peroxisome proliferator-activated receptors (PPARs) and several genes implicated in fatty acid transport and oxidation were evaluated on BAT. RESULTS: IL-15 treatment in rats causes a decrease in the mass of both WAT and BAT (35 and 24%, respectively). In BAT, an important upregulation of the mRNA content of thermogenic proteins (UCP1 and UCP3), lipid-related transcription factors (PPARdelta and PPARalpha) and other proteins implicated in membrane transport (fatty acid translocase (FAT) and fatty acid transport protein (FATP)), mitochondrial transport (carnitine palmitoyl transferase-I (CPT-I) and CPT-II) and consumption (acyl-CoA synthetase 4 (ACS4)) of fatty acids was observed as a consequence of the treatment. DISCUSSION: The changes observed in BAT suggest that IL-15 could be implicated in lipid consumption in this tissue by regulating lipid oxidation and probably thermogenesis, processes mediated by UCPs and PPARs.
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IL-15 enhances BAT activity in rodents.
“IL-15 was found to enhance the activity of BAT in rodents [275] (2).”
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- Authors
- Almendro, V., Fuster, G., Busquets, S., Ametller, E., Figueras, M., Argilés, J. M., & López‐Soriano, F. J.
- Affiliations
- Universitat de Barcelona (ES)
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2008-02
- Volume
- 16
- Issue
- 2
- Pages
- 285-289
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1992771950
- Cited by
- 49
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dirección General de Investigación Científica y Técnica
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- IL-15, brown adipose tissue, uncoupling proteins, UCP1, UCP3, peroxisome proliferator-activated receptors, PPARδ, PPARα, fatty acid oxidation, thermogenesis, fatty acid uptake, carnitine palmitoyltransferase, lipid metabolism
- MeSH terms
- Uncoupling Protein 3, Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Fatty Acids, Ion Channels, Male, Oxidation-Reduction, RNA, Messenger, Rats, Wistar, Interleukin-15, Thermogenesis, Mitochondrial Proteins, PPAR alpha, PPAR delta, Lipid Metabolism, Rats
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