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A 12‐Week Aerobic Exercise Program Reduces Hepatic Fat Accumulation and Insulin Resistance in Obese, Hispanic Adolescents
Open accessAbstract
The rise in obesity‐related morbidity in children and adolescents requires urgent prevention and treatment strategies. Currently, only limited data are available on the effects of exercise programs on insulin resistance, and visceral, hepatic, and intramyocellular fat accumulation. We hypothesized that a 12‐week controlled aerobic exercise program without weight loss reduces visceral, hepatic, and intramyocellular fat content and decreases insulin resistance in sedentary Hispanic adolescents. Twenty‐nine postpubertal (Tanner stage IV and V), Hispanic adolescents, 15 obese (7 boys, 8 girls; 15.6 ± 0.4 years; 33.7 ± 1.1 kg/m 2 ; 38.3 ± 1.5% body fat) and 14 lean (10 boys, 4 girls; 15.1 ± 0.3 years; 20.6 ± 0.8 kg/m 2 ; 18.9 ± 1.5% body fat), completed a 12‐week aerobic exercise program (4 × 30 min/week at ≥70% of peak oxygen consumption (VO 2 peak)). Measurements of cardiovascular fitness, visceral, hepatic, and intramyocellular fat content (magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS)), and insulin resistance were obtained at baseline and postexercise. In both groups, fitness increased (obese: 13 ± 2%, lean: 16 ± 4%; both P < 0.01). In obese participants, intramyocellular fat remained unchanged, whereas hepatic fat content decreased from 8.9 ± 3.2 to 5.6 ± 1.8%; P < 0.05 and visceral fat content from 54.7 ± 6.0 to 49.6 ± 5.5 cm 2 ; P < 0.05. Insulin resistance decreased indicated by decreased fasting insulin (21.8 ± 2.7 to 18.2 ± 2.4 µU/ml; P < 0.01) and homeostasis model assessment of insulin resistance (HOMA IR ) (4.9 ± 0.7 to 4.1 ± 0.6; P < 0.01). The decrease in visceral fat correlated with the decrease in fasting insulin ( R 2 = 0.40; P < 0.05). No significant changes were observed in any parameter in lean participants except a small increase in lean body mass (LBM). Thus, a controlled aerobic exercise program, without weight loss, reduced hepatic and visceral fat accumulation, and decreased insulin resistance in obese adolescents.
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Cited by
Lee, S., Bacha, F., Hannon, T., Kuk, J. L., Boesch, C., & Arslanian, S. (2012) · Diabetes · doi:10.2337/db12-0214 · Cited by 398
Zhang, H.-J., He, J., Pan, L.-L., Ma, Z.-M., Han, C.-K., Chen, C.-S., Chen, Z., Han, H.-W., Chen, S., Sun, Q., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.3202 · Cited by 276
Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial
Zelber-Sagi, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i15.4382 · Cited by 152
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults
Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I., & Nair, K. S. (2016) · Diabetes · doi:10.2337/db15-0675 · Cited by 129
Metadata
- Authors
- van der Heijden, G., Wang, Z. J., Chu, Z. D., Sauer, P. J. J., Haymond, M. W., Rodriguez, L. M., & Sunehag, A. L.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 18
- Issue
- 2
- Pages
- 384-390
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2104303595
- Cited by
- 253
- References
- 8
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van der Heijden, G., Wang, Z. J., Chu, Z. D., Sauer, P. J. J., Haymond, M. W., Rodriguez, L. M., & Sunehag, A. L. (2010). A 12‐Week Aerobic Exercise Program Reduces Hepatic Fat Accumulation and Insulin Resistance in Obese, Hispanic Adolescents. Obesity. https://doi.org/10.1038/oby.2009.274
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