Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans
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OBJECTIVE: Fatty liver may be involved in the pathogenesis of type 2 diabetes. Physical exercise is a tool to improve insulin sensitivity, but little is known about its effect on intrahepatic fat (IHF) content. The purpose of this study was to examine the association of habitual physical activity, insulin resistance, and adiponectin with IHF content. RESEARCH DESIGN AND METHODS: Participants were 191 (77 female and 114 male) apparently healthy, nonalcoholic individuals (aged 19-62 years; BMI 17.0-35.5 kg/m2). IHF content was assessed in a quantitative fashion and noninvasively as a continuous variable by means of 1H magnetic resonance spectroscopy (MRS), and habitual physical activity was assessed by means of a questionnaire. Fatty liver was defined as IHF content of >5% wet weight, and insulin sensitivity was estimated using the computer homeostasis model assessment (HOMA)-2 indexes. RESULTS: A reduced prevalence of fatty liver in the quartile of the most physically active individuals (25, 11, 25, and 2% in quartile 1, 2, 3, and 4, respectively; chi2 = 15.63; P = 0.001) was found along with an inverse correlation between the physical activity index and the IHF content when plotted as continuous variables (Pearson's r = -0.27; P < 0.000). This association was not attenuated when adjusted for age, sex, BMI, HOMA-2, and adiponectin (partial correlation r = -0.25; P < 0.001). CONCLUSIONS: This study demonstrated that a higher level of habitual physical activity is associated with a lower IHF content and suggested that this relationship may be due to the effect of exercise per se.
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Low habitual physical activity is associated with higher intrahepatic fat content in healthy, nonalcoholic males and females ages 19-62.
“A second study reported a low level of habitual physical activity was associated with higher intrahepatic fat content in healthy, nonalcoholic males and females ages 19–62 (407).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [407]
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- Authors
- Perseghin, G., Lattuada, G., De Cobelli, F., Ragogna, F., Ntali, G., Esposito, A., Belloni, E., Canu, T., Terruzzi, I., Scifo, P., Del Maschio, A., & Luzi, L.
- Affiliations
- University of Milan (IT)
- IRCCS Ospedale San Raffaele (IT)
- Unit of Clinical Spectroscopy, San Raffaele Scientific Institute, Milan, Italy
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2007-03-01
- Volume
- 30
- Issue
- 3
- Pages
- 683-688
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2075760095
- Cited by
- 320
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 15 · 2018: 68 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 18
- FWCI
- 18.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Harokopio University
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- physical activity behavior, intrahepatic fat, hepatic steatosis, insulin resistance, adiponectin, type 2 diabetes, physical activity, 1H magnetic resonance spectroscopy
- MeSH terms
- Adipose Tissue, Adult, Blood Pressure, Fatty Liver, Female, Humans, Liver, Male, Middle Aged, Physical Fitness, Reference Values, Exercise, Prevalence
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