Maternal inflammation promotes fetal microglial activation and increased cholinergic expression in the fetal basal forebrain: role of interleukin-6

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works

A rapid radiochemical method for the determination of choline acetyltransferase

Fonnum, F. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb11895.x · Cited by 2,358 · see citing works

Neuroglial activation and neuroinflammation in the brain of patients with autism

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 2× · see citing works

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421 · see citing works

Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring

Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works

Common genetic variants on 5p14.1 associate with autism spectrum disorders

Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works

Neuroanatomic observations of the brain in autism: a review and future directions

Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919 · see citing works

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., Courchesne, E., & Everall, I. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.024 · Cited by 749 · see citing works

The neurobiology of autism

Pardo, C. A., & Eberhart, C. G. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00102.x · Cited by 514 · see citing works

Cytokine Induction in Fetal Rat Brains and Brain Injury in Neonatal Rats after Maternal Lipopolysaccharide Administration

Cai, Z., Pan, Z.-L., Pang, Y., Evans, O. B., & Rhodes, P. G. (2000) · Pediatric Research · doi:10.1203/00006450-200001000-00013 · Cited by 507 · see citing works

What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

Crawley, J. N. (2007) · doi:10.1002/0470119055 · Cited by 474 · see citing works

Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain

Urakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405 · see citing works

Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain

Perry, E. K., Lee, M., Martin-Ruiz, C. M., COURT, J. A., Volsen, S. G., Merrit, J., Folly, E. A., Iversen, P. E., Bauman, M. L., Perry, R. H., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1058 · Cited by 390 · see citing works

The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia

Ashdown, H. F., Dumont, Y., Ng, M., Poole, S., Boksa, P., & Luheshi, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001748 · Cited by 387 · see citing works

Transfer of Inflammatory Cytokines Across the Placenta

Zaretsky, M. V., Alexander, J. M., Byrd, W., & Bawdon, R. E. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000114980.40445.83 · Cited by 376 · see citing works

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

Garay, P. A., Hsiao, E. Y., Patterson, P. H., & McAllister, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.008 · Cited by 366 · see citing works

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

Wei, H., Zou, H., Sheikh, A. M., Malik, M., Dobkin, C., Brown, W. T., & Li, X. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-52 · Cited by 333 · see citing works

Activation of the Inflammatory Response System in Autism

Croonenberghs, J., Bosmans, E., Deboutte, D., Kenis, G., & Maes, M. H. J. (2002) · Neuropsychobiology · doi:10.1159/000048665 · Cited by 323 · see citing works

Cerebrospinal Fluid and Serum Markers of Inflammation in Autism

Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300 · see citing works

Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA A dysregulation and impaired spatial learning

Samuelsson, A., Jennische, E., Hansson, H., & Holmäng, A. B. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2005 · Cited by 283 · see citing works

Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness

Patterson, P. H. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00299-4 · Cited by 269 · see citing works

Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia

Fatemi, S. H., Earle, J., Kanodia, R., Kist, D., Emamian, E. S., Patterson, P. H., Shi, L., & Sidwell, R. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1015337611258 · Cited by 261 · see citing works

Effect of inflammation on central nervous system development and vulnerability: review

Hagberg, H., & Mallard, C. E. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000162851.44897.8f · Cited by 259 · see citing works

Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling

Meyer, U., Murray, P. J., Urwyler, A., Yee, B. K., Schedlowski, M., & Feldon, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002042 · Cited by 252 · see citing works

Maternal Exposure to LPS Induces Hypomyelination in the Internal Capsule and Programmed Cell Death in the Deep Gray Matter in Newborn Rats

Rousset, C. I., Chalon, S., Cantagrel, S., Bodard, S., Andres, C. R., Gressèns, P., & Saliba, É. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000199905.08848.55 · Cited by 181 · see citing works

The effects of maternal inflammation on neuronal development: possible mechanisms

Jonakait, G. M. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.08.017 · Cited by 141 · see citing works

Microglial Activation in Perinatal Rabbit Brain Induced by Intrauterine Inflammation: Detection with 11C-(R)-PK11195 and Small-Animal PET

Kannan, S., Saadani‐Makki, F., Muzik, O., Chakraborty, P. K., Mangner, T. J., Janisse, J. J., Romero, R. J., & Chugani, D. C. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.106.038539 · Cited by 98 · see citing works

Altered expression of pro-inflammatory and developmental genes in the fetal brain in a mouse model of maternal infection

Liverman, C. S., Kaftan, H. A., Cui, L., Hersperger, S. G., Taboada, E. M., Klein, R. M., & Berman, N. E. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.064 · Cited by 80 · see citing works

Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic poly I:C at mid-pregnancy

Ratnayake, U., Quinn, T. A., Castillo-Melendez, M., Dickinson, H., & Walker, D. W. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.011 · Cited by 75 · see citing works

Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation

Hutton, L. C., Castillo-Meléndez, M., Smythe, G. A., & Walker, D. W. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.06.035 · Cited by 54 · see citing works

Conditioned Medium from Activated Microglia Promotes Cholinergic Differentiation in the Basal Forebrainin Vitro

Jonakait, G. M., Luskin, M. B., Wei, R., Tian, X.-F., & Ni, L. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0147 · Cited by 52 · see citing works

Effects of maternal exposure to LPS on the inflammatory response in the offspring

Lasala, N., & Zhou, H. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.07.010 · Cited by 51 · see citing works

Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review

Macêdo, D. S., de Araújo, D. P., Sampaio, L. R. L., Vasconcelos, S. M. M., Sales, P. M. G., de Sousa, F. C. F., Hallak, J. E. C., Crippa, J. A., & Carvalho, A. F. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500031 · Cited by 44 · see citing works

Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro

Mazzoni, I. E., & Kenigsberg, R. L. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00235-7 · Cited by 26 · see citing works

Toll-Like Receptor Ligands and CD154 Stimulate Microglia to Produce a Factor(s) That Promotes Excess Cholinergic Differentiation in the Developing Rat Basal Forebrain: Implications for Neurodevelopmental Disorders

Ni, L., Acevedo, G., Muralidharan, B., Padala, N. K., To, J. Q., & Jonakait, G. M. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000249981.70618.18 · Cited by 23 · see citing works

Microbiology and Immunology of Autism Spectrum Disorders

Lipkin, W. I., & Hornig, M. (2003) · Novartis Foundation symposium · doi:10.1002/0470869380.ch9 · Cited by 19 · see citing works

Microglial regulation of cholinergic differentiation in the basal forebrain

Jonakait, G. M., Pratt, L., Acevedo, G., & Ni, L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20969 · Cited by 11 · see citing works

GABAergic Circuit Development and Its Implication for CNS Disorders

Cristo, G. D., Pizzorusso, T., Cancedda, L., & Sernagor, E. (2011) · Neural Plasticity · doi:10.1155/2011/623705 · Cited by 9 · see citing works

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works

Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates

Careaga, M., Murai, T., & Bauman, M. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.020 · Cited by 348 · see citing works

Long-term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero

al-Haddad, B. J. S., Jacobsson, B., Chabra, S., Modzelewska, D., Olson, E. M., Bernier, R., Enquobahrie, D. A., Hagberg, H., Östling, S., Rajagopal, L., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0029 · Cited by 282 · see citing works

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

Bergdolt, L., & Dunaevsky, A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.002 · Cited by 266 · see citing works

Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

Hughes, H. K., Moreno, R. J., & Ashwood, P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.001 · Cited by 266 · see citing works

The fetal origins of mental illness

al-Haddad, B. J. S., Oler, E., Armistead, B., Elsayed, N. A., Weinberger, D. R., Bernier, R., Burd, I. D., Kapur, R. P., Jacobsson, B., Wang, C., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.06.013 · Cited by 265 · see citing works

Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits

Paolicelli, R. C., & Ferretti, M. T. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00009 · Cited by 235 · see citing works

The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation

Comer, A. L., Carrier, M., Tremblay, M., & Cruz‐Martín, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00274 · Cited by 204 · see citing works

Maternal Immune Activation by Poly I:C as a preclinical Model for Neurodevelopmental Disorders: A focus on Autism and Schizophrenia

Haddad, F. L., Patel, S. V., & Schmid, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.012 · Cited by 195 · see citing works

Maternal immune activation in neurodevelopmental disorders

Solek, C. M., Farooqi, N., Verly, M., Lim, T. K., & Ruthazer, E. S. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24612 · Cited by 168 · see citing works

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies

Giovanoli, S., Weber‐Stadlbauer, U., Schedlowski, M., Meyer, U., & Engler, H. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.015 · Cited by 139 · see citing works

Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood

Schaafsma, W., Bozal‐Basterra, L., Jacobs, S., Brouwer, N., Meerlo, P., Schaafsma, A., Boddeke, E., & Eggen, B. J. L. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.07.017 · Cited by 135 · see citing works

The role of IL-6 in neurodevelopment after prenatal stress

Gumusoglu, S. B., Fine, R. S., Murray, S. J., Bittle, J. L., & Stevens, H. E. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.05.015 · Cited by 129 · see citing works

Maternal immune activation induces sustained changes in fetal microglia motility

Ozaki, K., Kato, D., Ikegami, A., Hashimoto, A., Sugio, S., Guo, Z., Shibushita, M., Tatematsu, T., Haruwaka, K., Moorhouse, A. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78294-2 · Cited by 119 · see citing works

Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms

Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works

Bridging autism spectrum disorders and schizophrenia through inflammation and biomarkers – pre-clinical and clinical investigations

Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works

Maternal immune activation, central nervous system development and behavioral phenotypes

Minakova, E., & Warner, B. B. (2018) · Birth Defects Research · doi:10.1002/bdr2.1416 · Cited by 108 · see citing works

Controversies and prospects about microglia in maternal immune activation models for neurodevelopmental disorders

Smolders, S., Notter, T., Smolders, S., Rigo, J., & Brône, B. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.001 · Cited by 93 · see citing works

The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring

Wu, W., Adams, C. E., Stevens, K. E., Chow, K.-H. K., Freedman, R., & Patterson, P. H. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.005 · Cited by 84 · see citing works

Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity

Edlow, A. G., Glass, R. M., Smith, C. J. W., Tran, P. K., James, K. E., & Bilbo, S. D. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.004 · Cited by 84 · see citing works

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

Smith, G. A., Rocha, E. M., Rooney, T., Barnéoud, P., McLean, J. R., Beagan, J. A., Osborn, T. M., Coimbra, M., Luo, Y., Hallett, P. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121072 · Cited by 78 · see citing works

Maternal Immune Activation Causes Schizophrenia-like Behaviors in the Offspring through Activation of Immune-Inflammatory, Oxidative and Apoptotic Pathways, and Lowered Antioxidant Defenses and Neuroprotection

Talukdar, P. M., Abdul, F., Maes, M. H. J., Binu, V. S. N., Venkatasubramanian, G., Kutty, B. M., & Debnath, M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02028-8 · Cited by 72 · see citing works

Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the offspring brain

Woods, R. M., Lorusso, J. M., Potter, H. G., Neill, J. C., Glazier, J. D., & Hager, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.015 · Cited by 72 · see citing works

Gestational diabetes exacerbates maternal immune activation effects in the developing brain

Money, K. M., Barke, T. L., Serezani, A. P. M., GANNON, M. A., Garbett, K. A., Aronoff, D. M., & Mirnics, K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.191 · Cited by 68 · see citing works

Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo

Smolders, S., Smolders, S., Swinnen, N., Gärtner, A., Rigo, J., Legendre, P., & Brône, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00301 · Cited by 66 · see citing works

Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation

Hui, C. W., Vecchiarelli, H. A., Gervais, É., Luo, X., Michaud, F., Scheefhals, L., Bisht, K., Sharma, K., Topolnik, L., & Tremblay, M.-È. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.558181 · Cited by 64 · see citing works

Preclinical animal models of mental illnesses to translate findings from the bench to the bedside: Molecular brain mechanisms and peripheral biomarkers associated to early life stress or immune challenges

Cattane, N., Vernon, A. C., Borsini, A., Scassellati, C., Endres, D., Capuron, L., Tamouza, R., Benros, M. E., Leza, J. C., Pariante, C. M., et al. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.02.002 · Cited by 64 · see citing works

Systemic maternal inflammation promotes ASD via IL-6 and IFN-γ

Majerczyk, D., Ayad, E., Brewton, K. L., Saing, P., & Hart, P. C. (2022) · Bioscience Reports · doi:10.1042/bsr20220713 · Cited by 62 · see citing works

Recent advances in the understanding of microglial development and homeostasis

Low, D., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.004 · Cited by 54 · see citing works

Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress

Akhtar, F., Rouse, C. A., Catano, G., Montalvo, M., Ullevig, S. L., Asmis, R., Kharbanda, K. K., & Maffi, S. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0965-8 · Cited by 49 · see citing works

Blue Light Modulates Murine Microglial Gene Expression in the Absence of Optogenetic Protein Expression

Cheng, K. P., Kiernan, E. A., Eliceiri, K. W., Williams, J. C., & Watters, J. J. (2016) · Scientific Reports · doi:10.1038/srep21172 · Cited by 45 · see citing works

Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder

Hughes, H. K., Rowland, M. E., Onore, C. E., Rogers, S. J., Ciernia, A. V., & Ashwood, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01766-0 · Cited by 49 · see citing works

The poly(I:C)-induced maternal immune activation model; a systematic review and meta-analysis of cytokine levels in the offspring

Hameete, B. C., Fernández‐Calleja, J. M. S., de Groot, M. W. G. D. M., Oppewal, T. R., Tiemessen, M. M., Hogenkamp, A., de Vries, R. B. M., & Groenink, L. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100192 · Cited by 45 · see citing works

Microglial Activation and Psychotic Disorders: Evidence from Pre-clinical and Clinical Studies

Barichello, T., Simões, L. R., Quevedo, J., & Zhang, X. Y. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_81 · Cited by 43 · see citing works

The multifaceted roles of embryonic microglia in the developing brain

Hattori, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.988952 · Cited by 39 · see citing works

SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants

Figueiredo, C. P., Fontes-Dantas, F. L., Poian, A. T. D., & Clarke, J. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108841 · Cited by 37 · see citing works

The impact of (ab)normal maternal environment on cortical development

Vasistha, N. A., & Khodosevich, K. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102054 · Cited by 36 · see citing works

Altered Hippocampal Gene Expression and Morphology in Fetal Piglets following Maternal Respiratory Viral Infection

Antonson, A. M., Balakrishnan, B., Radlowski, E. C., Petr, G. T., & Johnson, R. W. (2018) · Developmental Neuroscience · doi:10.1159/000486850 · Cited by 36 · see citing works

Emerging roles for hypothalamic microglia as regulators of physiological homeostasis

Rosin, J. M., & Kurrasch, D. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100748 · Cited by 35 · see citing works

Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation

Hemmerle, A. M., Ahlbrand, R. A., Bronson, S. L., Lundgren, K. H., Richtand, N. M., & Seroogy, K. B. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.006 · Cited by 33 · see citing works

Maternal viral infection causes global alterations in porcine fetal microglia

Antonson, A. M., Lawson, M. A., Caputo, M. P., Matt, S. M., Leyshon, B. J., & Johnson, R. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817014116 · Cited by 32 · see citing works

Oxytocin and microglia in the development of social behaviour

Gonzalez, A. M., & Hammock, E. A. D. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0059 · Cited by 32 · see citing works

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Chow, K.-H. K., Yan, Z., & Wu, W. (2016) · Journal of Visualized Experiments · doi:10.3791/53643 · Cited by 27 · see citing works

Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update

Nayak, U., Manikkath, J., Arora, D., & Mudgal, J. (2025) · Metabolic brain disease · doi:10.1007/s11011-025-01548-3 · Cited by 22 · see citing works

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

Casey, S., Carter, M., Looney, A.-M., Livingstone, V., Moloney, G. M., O’Keeffe, G. W., Taylor, R. S., Kenny, L. C., McCarthy, F. P., McCowan, L. M. E., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05271-7 · Cited by 26 · see citing works

Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation

Konefal, S., & Stellwagen, D. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0160 · Cited by 25 · see citing works

In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus

Rosin, J. M., & Kurrasch, D. M. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1213-6 · Cited by 21 · see citing works

Brain in flames – animal models of psychosis: utility and limitations

Wolf, S. A., Mattei, D., & Schweibold, R. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65564 · Cited by 21 · see citing works

Why monkeys do not get multiple sclerosis (spontaneously)

Bove, R. M. (2018) · Evolution Medicine and Public Health · doi:10.1093/emph/eoy002 · Cited by 18 · see citing works

Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation

Sulistio, Y. A., Lee, H. K., Jung, S. J., & Heese, K. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0594-3 · Cited by 17 · see citing works

Neuroimmune mechanisms in autism etiology - untangling a complex problem using human cellular models

Vacharasin, J. M., Ward, J. A., McCord, M. M., Cox, K., Imitola, J., & Lizarraga, S. B. (2024) · Oxford Open Neuroscience · doi:10.1093/oons/kvae003 · Cited by 16 · see citing works

Innate Immune Dysfunction and Neuroinflammation in Autism Spectrum Disorder (ASD)

Hughes, H. K., Moreno, R. J., & Ashwood, P. (2024) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.24022004 · Cited by 14 · see citing works

Cerebral Response to Peripheral Challenge with a Viral Mimetic

Konat, G. W. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1746-3 · Cited by 14 · see citing works

Bisphenol A and microglia: could microglia be responsive to this environmental contaminant during neural development?

Rosin, J. M., & Kurrasch, D. M. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2017 · Cited by 12 · see citing works

CNS Macrophages and Infant Infections

Oschwald, A., Petry, P., Kierdorf, K., & Erny, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02123 · Cited by 10 · see citing works

Maternal Interleukin-6 Hampers Hippocampal Neurogenesis in Adult Rat Offspring in a Sex-Dependent Manner

Mouihate, A., & Kalakh, S. (2021) · Developmental Neuroscience · doi:10.1159/000516370 · Cited by 9 · see citing works

Birth triggers an inflammatory response in the neonatal periphery and brain.

Castillo-Ruiz, A., Cisternas, C., Sturgeon, H., & Forger, N. (2022) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2022.05.021 · Cited by 8 · see citing works

Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour

Haddad, F. L., Patel, S. V., Doornaert, E. E., Oliveira, C. D., Allman, B. L., Baines, K. J., Renaud, S. J., & Schmid, S. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100473 · Cited by 7 · see citing works

The inflammatory response to birth requires MyD88 and is driven by both mother and offspring

Gray, J. M., Major, K., Castillo‐Ruiz, A., Shipley, M., Gangappa, S., & Forger, N. G. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.011 · Cited by 7 · see citing works

Exogenous PD-L1 binds to PD-1 to alleviate and prevent autism-like behaviors in maternal immune activation-induced male offspring mice

Zeng, X., Fan, L., Qin, Q., Zheng, D., Wang, H., Li, M., Jiang, Y., Wang, H., Liu, H., Liang, S., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.042 · Cited by 5 · see citing works

Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model

Wang, X., Fu, J., Wang, H., Liu, C., Zhang, Y., Song, C., & Wang, C. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06632-7 · Cited by 6 · see citing works

Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids

Schmied, V., Korkut-Demirbaş, M., Venturino, A., Maya-Arteaga, J. P., & Siegert, S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03366-x · Cited by 7 · see citing works

Mapping the impact of exposure to maternal immune activation on juvenile Wistar rat brain macro- and microstructure during early post-natal development

Wood, T., Edye, M. E., Harte, M., Neill, J. C., Prinssen, E. P. M., & Vernon, A. C. (2019) · Brain and Neuroscience Advances · doi:10.1177/2398212819883086 · Cited by 5 · see citing works

The Role of Inflammation in Autism Spectrum Disorder

Ferretti, C. J., & Hollander, E. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-13602-8_14 · Cited by 5 · see citing works

Immunotherapy: An Approach to Treat Alzheimer’s Disease and Autism Spectrum Disorder

Maarfi, F., Hasan, Z., Khanam, A., Husain, A., Khan, M. H., & Khan, M. Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-4558-7_11 · Cited by 3 · see citing works

From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment

Mattei, D., Güneykaya, D., Ugursu, B., & Buonfiglioli, A. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00028-4 · Cited by 2 · see citing works

Modeling the Maternal Immune Activation Risk Factor for Schizophrenia

Malkova, N. V., Wu, W., & Hsiao, E. Y. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00011-0 · Cited by 2 · see citing works

Maternal and neonatal cytokine profiles in a twin cohort: evidence from an exploratory pilot study of perinatal immune dysregulation in autism

Imran, M. A., Mohebbi, M., Wright, C. R., Williams, R. J., Saffery, R., Craig, J. M., & Stephenson, G. (2026) · Pediatric Research · doi:10.1038/s41390-026-05308-6 · Cited by 1 · see citing works

Neurodevelopmental alterations in a mouse model of maternal immune activation

Fernandez, A. (2018) · theses.fr (ABES) · doi:10.70675/502cd79bzfc73z4f21z8675z5dea9ddf93e0 · Cited by 1 · see citing works

Inflammation and immune-mediated neurobehavioral alterations : a critical role for microglia

Lacabanne, C. (2018) · theses.fr (ABES) · doi:10.70675/41a4e2a3zdbb7z4aa0z899dz9553bb07954b · Cited by 1 · see citing works

Early life inflammation and the basolateral amygdala.

Szubra, A. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25769

Preliminary evidence that maternal immune activation specifically increases diagonal domain volume in the rat brain during early postnatal developmentPreprint

Wood, T., Edye, M. E., Harte, M., Neill, J. C., Prinssen, E. P. M., & Vernon, A. C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/432450

Inflammation and accumulating risk for developing psychiatric disorders

Money, K. M. (2016)

The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences

Sterling, K. (2020) · York University Digital Library (York University)

SARS-CoV-2 and its impact on the developing fetal neurologic system

Mody, K., Wade, C., & Micetic, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95648-2.00059-9

Gestational benzene exposure programs sex-specific neuroimmune responses to postnatal viral infection

Maxwell, A., Nguyen, A. T., Maxwell, D., Schick, S., Rao, A., Singh, A., Findeis, E., Ding, J., & Mor, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1952071

Microglia and immune signaling as architects of the brain

Kim, A., Solek, C. M., & Ruthazer, E. S. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1936860

Effects on the fetal cholinergic basal forebrain followingmaternal immune activation

Pratt, L. (2013) · doi:10.7282/t34q7sq5

Toll-Like Receptor Ligands and CD154 Stimulate Microglia to Produce a Factor(s) That Promotes Excess Cholinergic Differentiation in the Developing Rat Basal Forebrain: Implications for Neurodevelopmental Disorders

Ni, L., Acevedo, G., Muralidharan, B., Padala, N. K., To, J. Q., & Jonakait, G. M. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000249981.70618.18 · Cited by 23 · see citing works

Microglial regulation of cholinergic differentiation in the basal forebrain

Jonakait, G. M., Pratt, L., Acevedo, G., & Ni, L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20969 · Cited by 11 · see citing works

Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo

Smolders, S., Smolders, S., Swinnen, N., Gärtner, A., Rigo, J., Legendre, P., & Brône, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00301 · Cited by 66 · see citing works

ISDN2014_0199: Embryonic microglia are not activated during maternal immune activation in mice

Brône, B., Smolders, S., Smolders, S., Swinnen, N., Legendre, P., & Rigo, J. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.04.163