HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis
Open accessAbstract
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity is essential for downstream necroptotic signaling events. Since RIP3 kinase activity has been associated with various diseases, the development of specific RIP3 inhibitors is an attractive strategy for therapeutic application. In this study, we identified a potent RIP3 inhibitor, HS-1371, by the extensive screening of chemical libraries focused on kinases. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. Our results suggest that HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Treatment with small molecule inhibitors of RIPK3 (HS-1371) or MLKL (GW806742X) rescued Tbk1-null B16 cells from TNFα/IFNγ-induced cell death when combined with caspase inhibition.
“Consistent with our findings with RIPK1, treatment with small molecule inhibitors of RIPK3 (HS-1371) 38 or MLKL (GW806742X) 39 rescued Tbk1-null B16 cells from TNF α /IFN γ -induced cell death when combined with caspase inhibition (Extended Data Fig. 8d-e).”
From Targeting TBK1 to overcome resistance to cancer immunotherapy (2023) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Flaherty, K. T., Puzanov, I. J., Kim, K. B., Ribas, A., McArthur, G. A., Sosman, J. A., O'Dwyer, P. J., Lee, R. J., Grippo, J. F., Nolop, K. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002011 · Cited by 3,542 · see citing works
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068 · see citing works
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742 · see citing works
Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
Robert, C., Karaszewska, B., Schachter, J., Rutkowski, P. L., Mackiewicz, A. A., Stroyakovskiy, D., Lichinitser, M., Dummer, R., Grange, F., Mortier, L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1412690 · Cited by 2,698 · see citing works
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698 · see citing works
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works
Identification of RIP1 kinase as a specific cellular target of necrostatins
Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059 · see citing works
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931 · see citing works
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735 · see citing works
Wang, H., Sun, L., Su, L., Rizo, J., Liu, L., Wang, L., Wang, F., & Wang, X. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.003 · Cited by 1,564 · see citing works
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Cai, Z., Jitkaew, S., Zhao, J., Chiang, H.-C., Choksi, S., Liu, J., Ward, Y., Wu, L.-G., & Liu, Z.-G. (2014) · Nature Cell Biology · doi:10.1038/ncb2883 · Cited by 1,322 · see citing works
McArthur, G. A., Chapman, P. B., Robert, C., Larkin, J., Haanen, J. B., Dummer, R., Ribas, A., Hogg, D., Hamid, O., Ascierto, P. A., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70012-9 · Cited by 977 · see citing works
Cui, J. J., Tran‐Dubé, M., Shen, H., Nambu, M. D., Kung, P., Pairish, M., Jia, L., Meng, J. J., Funk, L. A., Botrous, I., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2007613 · Cited by 953 · see citing works
Zhao, J., Jitkaew, S., Cai, Z., Choksi, S., Li, Q., Luo, J., & Liu, Z.-G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200012109 · Cited by 901 · see citing works
Chen, X., Li, W., Ren, J., Huang, D., He, W., Song, Y., Yang, C., Li, W., Zheng, X., Chen, P., et al. (2013) · Cell Research · doi:10.1038/cr.2013.171 · Cited by 778 · see citing works
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
Newton, K., Dugger, D. L., Wickliffe, K. E., Kapoor, N., de Almagro, M. C., Vucic, D., Komuves, L., Ferrando, R. E., French, D. M., Webster, J., et al. (2014) · Science · doi:10.1126/science.1249361 · Cited by 687 · see citing works
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
Li, L., Thomas, R., Suzuki, H., Brabander, J. D., Wang, X.-D., & Harran, P. G. (2004) · Science · doi:10.1126/science.1098231 · Cited by 620 · see citing works
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, P., Berger, S. B., Pillay, S., Moriwaki, K., Huang, C., Guo, H., Lich, J. D., Finger, J. N., Kasparcova, V., Votta, B. J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.021 · Cited by 619 · see citing works
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
Duprez, L., Takahashi, N., Hauwermeiren, F. V., Vandendriessche, B., Goossens, V., Berghe, T. V., Declercq, W., Libert, C., Cauwels, A., & Vandenabeele, P. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.020 · Cited by 591 · see citing works
Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
Linkermann, A., Bräsen, J. H., Darding, M., Jin, M. K., Sanz, A. B., Heller, J.-O., Zen, F. D., Weinlich, R., Ortíz, A., Walczak, H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305538110 · Cited by 568 · see citing works
Initiation and execution mechanisms of necroptosis: an overview
Grootjans, S., Vanden Berghe, T., & Vandenabeele, P. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.65 · Cited by 566 · see citing works
Koo, G.-B., Morgan, M. J., Lee, D., Kim, W.-J., Yoon, J.-H., Koo, J. S., Kim, S. H., Kim, S., Son, M. K., Hong, S. S., et al. (2015) · Cell Research · doi:10.1038/cr.2015.56 · Cited by 489 · see citing works
Self-citationMany stimuli pull the necrotic trigger, an overview
Vanlangenakker, N., Berghe, T. V., & Vandenabeele, P. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.164 · Cited by 407 · see citing works
RIP3: a molecular switch for necrosis and inflammationPreprint
Moriwaki, K., & Chan, F. K.-M. (2013) · Genes & Development · doi:10.1101/gad.223321.113 · Cited by 353 · see citing works
Moriwaki, K., Bertin, J., Gough, P. J., Orlowski, G. M., & Chan, F. K. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.16 · Cited by 244 · see citing works
Li, J., Feng, J.-M., Wang, Y., Li, X.-H., Chen, X.-X., Su, Y., Shen, Y.-Y., Chen, Y., Xiong, B., Yang, C.-H., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.241 · Cited by 233 · see citing works
Structural Insights into RIP3-Mediated Necroptotic Signaling
Xie, T., Peng, W., Yan, C., Wu, J., Gong, X., & Shi, Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.044 · Cited by 192 · see citing works
Necroptosis in Immunity and Ischemia-Reperfusion Injury
Linkermann, A., Hackl, M. J., Kunzendorf, U., Walczak, H., Krautwald, S., & Jevnikar, A. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12448 · Cited by 188 · see citing works
Absence of RIPK3 predicts necroptosis resistance in malignant melanoma
Geserick, P., Wang, J., Schilling, R., Horn, S., Harris, P. A., Bertin, J., Gough, P. J., Feoktistova, M., & Leverkus, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.240 · Cited by 168 · see citing works
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
Chen, W., Wu, J., Li, L., Zhang, Z., Ren, J., Liang, Y., Chen, F., Yang, C., Zhou, Z., Sean Su, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3120 · Cited by 161 · see citing works
Viral modulation of programmed necrosis
Kaiser, W. J., Upton, J. W., & Mocarski, E. S. (2013) · Current Opinion in Virology · doi:10.1016/j.coviro.2013.05.019 · Cited by 149 · see citing works
B-Raf and the inhibitors: from bench to bedside
Huang, T., Karsy, M. J., Zhuge, J., Zhong, M., & Liu, D. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-30 · Cited by 100 · see citing works
Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)
de Koning, P. D., McAndrew, D., Moore, R., Moses, I. B., Boyles, D. C., Kissick, K., Stanchina, C. L., Cuthbertson, T. J., Kamatani, A., Rahman, L. T., et al. (2011) · Organic Process Research & Development · doi:10.1021/op200131n · Cited by 92 · see citing works
Kim, S. K., Kim, W., Yoon, J.-H., Ji, J., Morgan, M. J., Cho, H., Kim, Y. C., & Kim, Y. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.90 · Cited by 80 · see citing works
Self-citationClinical development of dabrafenib in BRAF mutant melanoma and other malignancies
Gibney, G. T., & Zager, J. S. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.794220 · Cited by 71 · see citing works
Hazeldine, S. T., Polin, L., Kushner, J., White, K., Corbett, T. H., Biehl, J., & Horwitz, J. P. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.11.034 · Cited by 65 · see citing works
The serine threonine kinase RIP3: lost and found
Morgan, M. J., & Kim, Y. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.6.068 · Cited by 37 · see citing works
Self-citationLabots, M., Gotink, K. J., Dekker, H., Azijli, K., van der Mijn, J. C., Huijts, C. M., Piersma, S. R., Jiménez, C. R., & Verheul, H. M. W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.114 · Cited by 28 · see citing works
Programmed cell death with a necrotic-like phenotype
Morgan, M. J., & Liu, Z.-G. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2012-0056 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Petralia, F., Tignor, N., Reva, B., Koptyra, M., Chowdhury, S., Rykunov, D., Krek, A., Ma, W., Zhu, Y., Ji, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.044 · Cited by 317 · see citing works
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 257 · see citing works
Lin, Y., Wang, Y., Ding, J., Jiang, A., Wang, J., Yu, M., Blake, S., Liu, S., Bieberich, C. J., Farokhzad, O. C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba9772 · Cited by 253 · see citing works
Guidelines for evaluating myocardial cell death
Mishra, P. K., Adameová, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2019 · Cited by 238 · see citing works
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
Martens, S., Hofmans, S., Declercq, W., Augustyns, K., & Vandenabeele, P. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.002 · Cited by 185 · see citing works
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
Wang, L., Zhu, Y., Zhang, L., Guo, L., Wang, X., Pan, Z., Jiang, X. L., Wu, F., & He, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06370-2 · Cited by 187 · see citing works
Chen, J., Kos, R., Garssen, J., & Redegeld, F. A. (2019) · Cells · doi:10.3390/cells8121486 · Cited by 179 · see citing works
Targeting TBK1 to overcome resistance to cancer immunotherapy
Sun, Y., Revach, O.-Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., et al. (2023) · Nature · doi:10.1038/s41586-023-05704-6 · Cited by 174 · see citing works
Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes
Yeo, H. K., Park, T. H., Kim, H. Y., Jang, H., Lee, J., Hwang, G., Ryu, S. E., Park, S. H., Song, H. K., Ban, H. S., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051323 · Cited by 142 · see citing works
Self-citationSmall-Molecule Inhibitors of Necroptosis: Current Status and Perspectives
Zhuang, C., & Chen, F. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01317 · Cited by 115 · see citing works
FGF/FGFR signaling: From lung development to respiratory diseases
Yang, L., Zhou, F., Zheng, D., Wang, D., Li, X., Zhao, C., & Huang, X. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.09.002 · Cited by 116 · see citing works
A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis
Werts, A. D., Fulton, W. B., Ladd, M. R., Saad-Eldin, A., Chen, Y. X., Kovler, M. L., Jia, H., Banfield, E. C., Buck, R. H., Goehring, K. C., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.002 · Cited by 109 · see citing works
The aging mouse brain: cognition, connectivity and calcium
Radulescu, C. I., Cerar, V., Haslehurst, P., Kopanitsa, M. V., & Barnes, S. J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102358 · Cited by 105 · see citing works
Tumor Necrosis Factor Alpha Signaling and Organogenesis
You, K., Gu, H., Yuan, Z., & Xu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.727075 · Cited by 104 · see citing works
Targeting necroptosis in anticancer therapy: mechanisms and modulators
Wu, Y., Dong, G., & Sheng, C. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.007 · Cited by 95 · see citing works
Sato, Y., Fu, Y., Liu, H., Lee, M. Y., & Shaw, M. H. (2021) · BMC Cancer · doi:10.1186/s12885-021-08974-3 · Cited by 94 · see citing works
RIPK3 signaling and its role in regulated cell death and diseases
Zhou, Y., Xiang, Y., Liu, S., Li, C., Dong, J., Kong, X., Ji, X., Cheng, X., & Zhang, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01957-w · Cited by 94 · see citing works
TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis
Jeon, J., Noh, H.-J., Lee, H., Park, H.-H., Ha, Y.-J., Park, S., Lee, H., Kim, S., Kang, H., Eyun, S.-I., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-217904 · Cited by 77 · see citing works
Self-citationKim, S. I., Noh, J., Kim, S., Choi, Y., Yoo, D. K., Lee, Y., Lee, H., Jung, J., Kang, C. K., Song, K., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd6990 · Cited by 74 · see citing works
Immunotherapy in Non-Small Cell Lung Cancer With Actionable Mutations Other Than EGFR
Seegobin, K., Majeed, U., Wiest, N. E., Manochakian, R., Lou, Y., & Zhao, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.750657 · Cited by 81 · see citing works
Phenolic Compounds Promote Diversity of Gut Microbiota and Maintain Colonic Health
Domínguez-Avila, J. A., Villa-Rodríguez, J. A., Montiel‐Herrera, M., Pacheco‐Ordaz, R., Roopchand, D. E., Venema, K., & González-Aguilar, G. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06676-7 · Cited by 72 · see citing works
Klomp, M. J., Dalm, S. U., de Jong, M., Feelders, R. A., Hofland, J., & Hofland, L. J. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09607-z · Cited by 69 · see citing works
Necroptosis: A Pathogenic Negotiator in Human Diseases
Chaouhan, H. S., Vinod, C., Mahapatra, N., Yu, S., Wang, I., Chen, K., Yu, T., & Li, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112714 · Cited by 68 · see citing works
Role of necroptosis in traumatic brain and spinal cord injuries
Hu, X., Xu, Y. M., Zhang, H., Li, Y., Wang, X., Xu, C., Ni, W., & Zhou, K. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.002 · Cited by 66 · see citing works
Mitochondria’s Role in the Maintenance of Cancer Stem Cells in Glioblastoma
Iranmanesh, Y., Jiang, B., Favour, O. C., Dou, Z., Wu, J., Li, J., & Sun, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.582694 · Cited by 65 · see citing works
Zhu, Z., Li, J., Si, J., Ma, B., Shi, H., Lv, J., Cao, W., Guo, Y., Millwood, I. Y., Walters, R. G., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.00199-2021 · Cited by 61 · see citing works
Aguirre, J. I., Castillo, E. J., & Kimmel, D. B. (2021) · Bone · doi:10.1016/j.bone.2021.116168 · Cited by 60 · see citing works
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors
Gardner, C. R., Davies, K. A., Zhang, Y., Brzozowski, M., Czabotar, P. E., Murphy, J. M., & Lessène, G. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01621 · Cited by 58 · see citing works
Maintenance of genome integrity and active homologous recombination in embryonic stem cells
Choi, E.-H., Yoon, S., Koh, Y. E., Seo, Y., & Kim, K. P. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0481-2 · Cited by 56 · see citing works
Nammian, P., Asadi-Yousefabad, S.-L., Daneshi, S., Sheikhha, M. H., Tabei, K., & Razban, V. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02110-x · Cited by 56 · see citing works
Wang, W., Gu, X., Wang, L., Pu, X., Feng, H., Xu, C., Lou, G., Shao, L., Xu, Y., Wang, Q., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03115-y · Cited by 54 · see citing works
Bedient, L., Pokharel, S. M., Chiok, K. L., Mohanty, I. P., Beach, S. S., Miura, T. A., & Bose, S. (2020) · Viruses · doi:10.3390/v12090932 · Cited by 54 · see citing works
Xia, K., Zhu, F., Yang, C., Wu, S., Yu, L. C., Ma, H., Yu, X., Zhao, C., Ji, Y., Ge, W., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.606119 · Cited by 53 · see citing works
Necroptosis signaling in liver diseases: An update
Saeed, W. K., Jun, D. W., Jang, K., & Koh, D. H. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104439 · Cited by 52 · see citing works
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases
Zhāng, Q., Hu, X., Zhao, W., Ban, X.-X., Li, Y., Huang, Y., Wan, H., He, Y., Liao, L., Shang, L., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.77994 · Cited by 51 · see citing works
Necroptosis inhibitors: mechanisms of action and therapeutic potential
Zhou, Y., Cai, Z., Zhai, Y., Yu, J., He, Y., He, Y., Jitkaew, S., & Cai, Z. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01905-6 · Cited by 53 · see citing works
Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome
Cao, P., Yang, W., Wang, P., Li, X., & Nashun, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664843 · Cited by 45 · see citing works
Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease
Mansour, H. M., Mohamed, A. F., El-Khatib, A. S., & Khattab, M. M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101841 · Cited by 44 · see citing works
Adameová, A., Horvath, C., Abdul‐Ghani, S., Varga, Z. V., Suleiman, M. S., & Dhalla, N. S. (2022) · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) · Cited by 42 · see citing works
Park, M., Cho, Y., Kim, D.-G., Yang, C., Lee, S. M., Dawson, T. L., Nakamizo, S., Kabashima, K., Lee, Y. W., & Jung, W. H. (2020) · mBio · doi:10.1128/mbio.01521-20 · Cited by 39 · see citing works
Mechanisms of Resistance to Checkpoint Blockade Therapy
Shi, H., Lan, J., & Yang, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3266-5_5 · Cited by 37 · see citing works
NAD hydrolysis by the tuberculosis necrotizing toxin induces lethal oxidative stress in macrophages
Pajuelo, D., González-Juarbe, N., & Niederweis, M. (2019) · Cellular Microbiology · doi:10.1111/cmi.13115 · Cited by 31 · see citing works
Chen, Z., Chen, G., & Zhao, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15542 · Cited by 34 · see citing works
Integration of RNA-Seq and proteomics data identifies glioblastoma multiforme surfaceome signature
Syafruddin, S. E., Nazarie, W. F. W. M., Moidu, N. A., Soon, B. H., & Mohtar, M. A. (2021) · BMC Cancer · doi:10.1186/s12885-021-08591-0 · Cited by 33 · see citing works
Carino, A., Graziosi, L., Marchianò, S., Biagioli, M., Marino, E., Sepe, V., Zampella, A., Distrutti, E., Donini, A., & Fiorucci, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.663771 · Cited by 31 · see citing works
Crosstalk Between Cell Death and Spinal Cord Injury: Neurology and Therapy
Song, Q., Cui, Q., Sun, S., Wang, Y., Yin, Y., & Zhang, L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04188-3 · Cited by 28 · see citing works
RIPK3: A New Player in Renal Fibrosis
Shi, Y., Chen, X., Huang, C., & Pollock, C. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00502 · Cited by 28 · see citing works
Wu, X.-H., Verschut, V., Woest, M., Ng-Blichfeldt, J., Matías, Á., Villetti, G., Accetta, A., Facchinetti, F., Gosens, R., & Kistemaker, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.609509 · Cited by 29 · see citing works
Jaleel, Z. A., Blasberg, E. A., Troiano, C. A., Montanaro, P., Mazzilli, S. A., Gertje, H. P., Crossland, N. A., Platt, M. P., & Spiegel, J. H. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12945 · Cited by 28 · see citing works
Kim, S., Park, D., Kim, J., Kim, D., Kim, H., Mori, T., Jung, H., Lee, D., Hong, S., Jeon, J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109417 · Cited by 30 · see citing works
Self-citationUpmanyu, K., & Upadhyay, S. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.09.003 · Cited by 26 · see citing works
Role of Necroptosis in Intervertebral Disc Degeneration
Khaleque, A., Kim, J. H., Hwang, B.-J., Kang, J.-K., Quan, M., & Kim, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015292 · Cited by 27 · see citing works
Self-citationZhao, X., Wilson, K. M., Uteshev, V. V., & He, J. J. (2021) · Brain · doi:10.1093/brain/awab251 · Cited by 24 · see citing works
Repairing damaged lungs using regenerative therapy
Khedoe, P. P. S. J., Wu, X., Gosens, R., & Hiemstra, P. S. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.05.002 · Cited by 22 · see citing works
Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets
Orang, F. N., & Shadbad, M. A. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06732-4 · Cited by 22 · see citing works
Understanding necroptosis and its therapeutic target for intervertebral disc degeneration
Wang, Z., Hu, X., Wang, W., Li, Y., Cui, P., Wang, P., Kong, C., Chen, X., & Lu, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110400 · Cited by 21 · see citing works
Targeting necroptosis: a promising avenue for respiratory disease treatment
Cao, X., Tan, J., Zheng, R., Wang, F., Zhou, L., Yi, J., Yuan, R., Dai, Q., Song, L., & Dai, A. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01804-6 · Cited by 21 · see citing works
Significance of Necroptosis in Cartilage Degeneration
Khaleque, M. A., Kim, J.-H., Tanvir, M. A. H., Park, J., & Kim, Y. (2024) · Biomolecules · doi:10.3390/biom14091192 · Cited by 20 · see citing works
Self-citationJo, J., Lee, D., Park, Y. H., Choi, H., Han, J., Park, D. H., Choi, Y.-K., Kwak, J., Yang, M.-K., Yoo, J., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113325 · Cited by 19 · see citing works
Salvadores, N., & Court, F. A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1758668 · Cited by 18 · see citing works
Flow Cytofluorometric Analysis of Molecular Mechanisms of Premature Red Blood Cell Death
Alfhili, M. A., & Lee, M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1514-0_11 · Cited by 19 · see citing works
Targeting PANoptosis: a promising therapeutic strategy for ALI/ARDS
Zhang, M., Shang, L., Zhou, F., Cai, Y., Wang, S., Li, J., Liu, Y., Huang, J., & Yang, S. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02168-z · Cited by 18 · see citing works
Kim, D.-K., Lee, J.-S., Lee, E. Y., Jang, H., Han, S., Kim, H. Y., Hwang, I.-Y., Choi, J.-W., Shin, H. M., Youn, H., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00707-7 · Cited by 18 · see citing works
DNA methylation signatures associated with prognosis of gastric cancer
Dai, J. M., Nishi, A., Li, Z., Zhang, Y., Zhou, T., You, W., Li, W., & Pan, K. (2021) · BMC Cancer · doi:10.1186/s12885-021-08389-0 · Cited by 18 · see citing works
Kobayashi, Y., Hashizume, H., Takiguchi, S., Ji, J., Kawano, R., Koiwai, K., Yamamoto, H., Elbadawy, M., Omatsu, T., Abugomaa, A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-024-84297-0 · Cited by 19 · see citing works
The Pivotal Role of Mitsugumin 53 in Cardiovascular Diseases
Jiang, W., Liu, M., Gu, C., & Ma, H. (2020) · Cardiovascular Toxicology · doi:10.1007/s12012-020-09609-y · Cited by 14 · see citing works
Guerrero‐Mauvecin, J., Fontecha‐Barriuso, M., López-Diaz, A. M., Ortíz, A., & Sanz, A. B. (2023) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2023.04.006 · Cited by 13 · see citing works
Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis
Shi, Y. H., Wu, C., Shi, J., Gao, T., Ma, H., Li, L., & Zhao, Y. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176508 · Cited by 13 · see citing works
Gao, W., Wang, M., Su, Y. R., Yu, Z., Liu, H., & Su, Z. G. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00942 · Cited by 12 · see citing works
Wang, Z., Zou, F., Wang, A., Yang, J. C., Jin, R., Wang, B., Shen, L., Qi, S., Liu, J., Liu, Q., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00993-5 · Cited by 11 · see citing works
Kim, H., Seo, E.-H., Bae, D. H., Haam, K., Jang, H.-R., Park, J., Kim, J., Kim, S., Kim, S., Jeong, H. Y., et al. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa083 · Cited by 11 · see citing works
Self-citationImmunotherapy of tumors by tailored nano-zeolitic imidazolate framework protected biopharmaceuticals
Dutta, S. (2021) · Biomaterials Science · doi:10.1039/d1bm01161h · Cited by 11 · see citing works
Biomolecules in cell-derived extracellular vesicle chariots as warriors to repair damaged tissues
Guo, Y., Wu, D., Zhang, X., Zhang, K., & Luo, Y. (2021) · Nanoscale · doi:10.1039/d1nr04999b · Cited by 11 · see citing works
Mooradally, A. W., Holborn, J., Singh, K. K., Tyler, M. W., Patnaik, D., Wesseling, H., Brandon, N. J., Steen, J. A. J., Graether, S. P., Haggarty, S. J., et al. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15440 · Cited by 11 · see citing works
Misehe, M., Matoušová, M., Dvořáková, A., Hercík, K., Škach, K., Chalupská, D., Dejmek, M., Šála, M., Hájek, M., Bouřa, E., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115717 · Cited by 10 · see citing works
Unveiling Anoikis‐related genes: A breakthrough in the prognosis of bladder cancer
Jiang, S., Yang, X., Lin, Y., Liu, Y., Tran, L. J., Zhang, J., Qiu, C., Ye, F., & Sun, Z. (2024) · The Journal of Gene Medicine · doi:10.1002/jgm.3651 · Cited by 10 · see citing works
Identification of foam cell biomarkers by microarray analysis
Song, Z., Lv, S., Wu, H., Qin, L., Cao, H., Zhang, B., & Ren, S. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01495-0 · Cited by 10 · see citing works
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome
Wang, Y., Song, M., Zhou, P., Wang, J., Zheng, J., & Xu, H. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108067 · Cited by 10 · see citing works
Zhou, W., Wu, C., Zhao, C., Huang, Z., Lu, S., Fan, X., Tan, Y., Stalin, A., You, R., Liu, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.742421 · Cited by 10 · see citing works
Tu, X., Zou, Z., Li, J., Zeng, S., Luo, Z., Li, G., Gao, Y., & Zhang, K. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003387 · Cited by 9 · see citing works
Linking necroptosis with liver aging and chronic inflammation in hepatic pathology
Nair, B., Menon, A., Khader, M. A., Sethi, G., & Nath, L. R. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123871 · Cited by 9 · see citing works
Lee, A., Yoo, D. K., Lee, Y., Jeon, S., Jung, S., Noh, J., Ju, S., Hwang, S., Kim, H. H., Kwon, S., et al. (2021) · Immune Network · doi:10.4110/in.2021.21.e34 · Cited by 9 · see citing works
Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties
Pléau, C., Peret, A., Pearlstein, É., Scalfati, T., Vigier, A., Marti, G., Michel, F. J., Marissal, T., & Crépel, V. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.609123 · Cited by 9 · see citing works
Sun, X., Wu, Y. H., Xu, F., & Liu, C.-F. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114633 · Cited by 8 · see citing works
Ma, D., Hu, S., Wang, C., Ai, J., Ma, J., Gao, T., Hong, Y., Wu, Z., Gu, M., Tang, X., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c03226 · Cited by 7 · see citing works
Jena, L., Bennie, L. A., McErlean, E. M., Pentlavalli, S., Glass, K., Burrows, J. F., Kett, V. L., Buckley, N. E., Coulter, J. A., Dunne, N., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00856-x · Cited by 7 · see citing works
Altered linkage pattern of N-glycan sialic acids in pseudomyxoma peritonei
Nummela, P., Heiskanen, A., Kytölä, S. I., Haglund, C. H., Lepistö, A., Satomaa, T., & Ristimaki, A. P. (2020) · Glycobiology · doi:10.1093/glycob/cwaa079 · Cited by 7 · see citing works
Recent Progress in Small-Molecule Inhibitors for Critical Therapeutic Targets of Necroptosis
Fang, Z., Wei, H., Gou, W., Chen, L., Bi, C., Hou, W., & Li, Y. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2020-0386 · Cited by 6 · see citing works
Hong, Y., Wu, Z., Jiang, J., Sun, Y., Ma, J.-H., Ai, J.-X., Wang, Y., Ma, D., Zhang, J., Yang, C. R., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117716 · Cited by 4 · see citing works
Guerrero‐Mauvecin, J., Fontecha‐Barriuso, M., López-Diaz, A. M., Ortíz, A., & Sanz, A. B. (2022) · Nefrología · doi:10.1016/j.nefro.2022.12.009 · Cited by 4 · see citing works
Byun, H., Kwon, S., Wagner, K., Shin, H., & Lim, H. J. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00788-z · Cited by 4 · see citing works
Jarabicová, I., Horváth, C., Marciníková, A., & Adameová, A. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144280 · Cited by 3 · see citing works
Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors
Kim, N., Park, C.-J., Kim, Y., Ryu, S., Cho, H., Nam, Y., Han, M., Shin, J., & Sim, T. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115635 · Cited by 3 · see citing works
Self-citationFasciitis induced by sintilimab in a patient with recurrent hepatocellular carcinoma
Ning, C., Zhang, X., Yang, X., Zhao, H., & Wang, H. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.06.046 · Cited by 2 · see citing works
Shu, Y., Li, S., Yang, S., Zhang, S., Li, B., & Dong, L. D. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1759908 · Cited by 1 · see citing works
Immuno-modulating Mediators of Colon Cancer as Immuno-therapeutic: Mechanism and Potential
Kumar, C., Singh, R. P., Dwivedi, M. K., & Amit, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-63369-1_14 · Cited by 1 · see citing works
Immune Checkpoint Inhibitors as an Armor for Targeted Immunotherapy of Colorectal Cancer
Kapoor, S., & Padwad, Y. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-63369-1_15 · Cited by 1 · see citing works
Targeting Necroptosis as Therapeutic Potential in Central Nervous System Diseases
Li, H., Xia, M., Chen, J., Kostrzewa, R. M., & Xu, X. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_166 · Cited by 1 · see citing works
Targeting Necroptosis as Therapeutic Potential in Central Nervous System Diseases
Li, H., Xia, M., Chen, J., Kostrzewa, R. M., & Xu, X. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_166-1
- Authors
- Park, H.-H., Park, S.-Y., Mah, S., Park, J.-H., Hong, S.-S., Hong, S., & Kim, Y.-S.
- Affiliations
- Ajou University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Hong, Soon-Sun
- Hong, Sungwoo
- Kim, You-Sun
- Venue
- Experimental & Molecular Medicine
- Published
- 2018-09
- Volume
- 50
- Issue
- 9
- Pages
- 1-15
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- PMC
- PMC6148246
- OpenAlex
- W2885340691
- Cited by
- 110
- References
- 41
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 5 · 2021: 42 · 2020: 19 · 2019: 6
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Korea Health Industry Development Institute (HI15C0554)
- Institute for Basic Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- necroptosis, RIPK3, programmed cell death, kinase inhibition, apoptosis
- MeSH terms
- Animals, Cell Line, Humans, Necrosis, Phosphorylation, Phosphoserine, Piperidines, Pyrazoles, Quinolines, Tumor Necrosis Factor-alpha, Apoptosis, Cytoprotection, Protein Kinase Inhibitors, Mice, Receptor-Interacting Protein Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
