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The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Brain organoids: a next step for humanized Alzheimer’s disease models?

Gerakis, Yannis, Hetz, Claudio·2019·Molecular Psychiatry
DOI 10.1038/s41380-018-0343-7
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Crossref · 10.1038/s41380-018-0343-7

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  • The HNO model recapitulates some key pathological features of AD and offers greater complexity and translational potential compared to conventional cell and animal models.

    “The HNO model has been shown to recapitulate some of the key pathological features of AD and offers greater complexity and translational potential as compared to conventional cell and animal models92–95.”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [95]

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Research works printed but not linked: 25

  1. Zahs KR, Ashe KH. ‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer’s disease? Trends Neurosci. 2010;33:381–9. · DOI
  2. Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, Strooper BD, et al. APP mouse models for Alzheimer’s disease preclinical studies. EMBO J. 2017;36:2473–87. · DOI · Paper page
  3. Andorfer C, Kress Y, Espinoza M, Silva RD, Tucker KL, Barde YA, et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem. 2003;86:582–90. · DOI · Paper page
  4. Tiscornia G, Vivas EL, Belmonte JCI. Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. Nat Med. 2011;17:1570–6. · DOI
  5. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LNP, et al. The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014;23:3523–36. · DOI · Paper page
  6. Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA, et al. Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol. 2000;157:277–86. · DOI · Paper page
  7. Hetz C, Saxena S. ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol. 2017;13:477–91. · DOI
  8. Scheper W, Hoozemans JJM. The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol. 2015;130:315–31. · DOI
  9. Hashimoto S, Saido TC. Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer’s disease. Open Biol. 2018;8:1098rsob.180024. · DOI · Paper page
  10. Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, et al. Induction of the unfolded protein response and cell death pathway in Alzheimer’s disease, but not in aged Tg2576 mice. Exp Mol Med. 2010;42:386–94. · DOI
  11. Soto C. Transmissible protein: expanding the Prion Heresy. Cell . 2012;148:968–77. · DOI
  12. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, et al. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1–induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014;71:1481–9. · DOI · Paper page
  13. Moore S, Evans LDB, Andersson T, Portelius E, Smith J, Dias TB, et al. APP metabolism regulates tau proteostasis in human cerebral cortex neurons. Cell Rep. 2015;11:689–96. · DOI · Paper page
  14. Combs B, Kneynsberg A, Kanaan NM. Gene therapy models of Alzheimer’s disease and other dementias. Methods Mol Biol. 2016;1382:339–66. · DOI
  15. Hunsberger JG, Rao M, Kurtzberg J, Bulte JWM, Atala A, LaFerla FM, et al. Accelerating stem cell trials for Alzheimer’s disease. Lancet Neurol. 2016;15:219–30. · DOI
  16. Sproul AA. Being human: The role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer’s disease models. Mol Asp Med. 2015;43–44:54–65. · DOI
  17. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA et al. Adeno-associated viral vector (serotype 2)-nerve growth factor for patients with Alzheimer disease: a randomized clinical trial. JAMA Neurol. 2018; https://doi.org/10.1001/jamaneurol.2018.0233 · DOI · Paper page
  18. Bishop KM, Hofer EK, Mehta A, Ramirez A, Sun L, Tuszynski MH, et al. Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons. Exp Neurol. 2008;211:574–84. · DOI
  19. Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM, et al. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol. 2009;215:153–9. · DOI
  20. Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Brauniger M, et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci USA. 2015;112:15672–7. · DOI
  21. Lancaster MA, Knoblich JA. Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 2014;9:2329–40. · DOI · Paper page
  22. Takebe T, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, et al. Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation. Cell Stem Cell. 2015;16:556–65. · DOI
  23. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, et al. An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018;36:432–41. · DOI · Paper page
  24. Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330:841–5. · DOI · Paper page
  25. Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, et al. Efficient derivation of microglia-like cells from human pluripotent stem cells. Nat Med. 2016;22:1358–67. · DOI · Paper page

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Metadata

Authors
Gerakis, Y., & Hetz, C.
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2019-01-07
Volume
24
Issue
4
Pages
474-478
ISSN
  • 1359-4184
  • 1476-5578
DOI
10.1038/s41380-018-0343-7
Cited by
64
References
18
Language
en
Licence

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