Stem cell models of Alzheimer’s disease: progress and challenges

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

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Neuropathological stageing of Alzheimer-related changes.

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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RNA-Guided Human Genome Engineering via Cas9

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Cerebral organoids model human brain development and microcephaly

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

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Organoid Models and Applications in Biomedical Research

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Neuropathological alterations in Alzheimer disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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<i>TREM2</i> Variants in Alzheimer's Disease

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Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

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Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

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Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

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Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

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Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Generation of cerebral organoids from human pluripotent stem cells

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

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Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes

Lampinen, R., Belaya, I., Boccuni, I., Malm, T., & Kanninen, K. M. (2018) · Astrocyte - Physiology and Pathology · doi:10.5772/intechopen.71825 · Cited by 8 · see citing works

Introductory Chapter: Concept of Neuroprotection - A New Perspective

Chang, R. C., & Ho, J. Y. S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85631 · Cited by 8 · see citing works

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity

Phadke, L., Lau, D. H. W., Aghaizu, N. D., Ibarra, S., Navarrón, C. M., Granat, L., Magno, L., Whiting, P. J., & Jolly, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1056067 · Cited by 8 · see citing works

Human neurons lacking amyloid precursor protein exhibit cholesterol‐associated developmental and presynaptic deficits

Mesa, H., Zhang, E. Y., Wang, Y., & Zhang, Q. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30999 · Cited by 8 · see citing works

Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide

Tucker, M., Liao, G. Y., Keely, A., Park, J. Y., Rosenfeld, M., Wezeman, J., Mangalindan, R., Ratner, D., Darvas, M., & Ladiges, W. (2024) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2024.09.148 · Cited by 7 · see citing works

AI reveals insights into link between CD33 and cognitive impairment in Alzheimer’s Disease

Raschka, T., Sood, M., Schultz, B. T., Altay, A., Ebeling, C., & Fröhlich, H. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009894 · Cited by 5 · see citing works

Dimethysiloxane polymer for the effective transdermal delivery of donepezil in Alzheimer's disease treatment

Lee, J., Ju, I. G., Lim, Y., Kim, J. H., Lee, S.-M., Choi, Y., Oh, M. S., Kim, J., & Kim, D. (2024) · Biomaterials Science · doi:10.1039/d4bm01368a · Cited by 5 · see citing works

Neuroscience models: choose your dimension

Marx, V. (2018) · Nature Methods · doi:10.1038/s41592-018-0191-z · Cited by 5 · see citing works

Cellular Technologies in Traumatology: from Cells to Tissue Engineering

Дремина, Н. Н., Сергеевна, Т. И., & Александровна, Ш. И. (2021) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2020-5.6.8 · Cited by 5 · see citing works

Research Progress on Neural Cell Culture Systems

Li, T., Qin, X., & Ao, Q. (2025) · Current Neuropharmacology · doi:10.2174/011570159x360193250219082312 · Cited by 4 · see citing works

Three-dimensional culture systems in central nervous system research

Onuwaje, I., & Phillips, J. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818084-6.00016-7 · Cited by 4 · see citing works

The Fate and Dynamics of Neural Stem Cells (NSCs) and Their Neurogenic Decline in Alzheimer’s Disease

Naffaa, M. M. (2025) · Lifespan development and mental health. · doi:10.70322/ldmh.2025.10005 · Cited by 3 · see citing works

Merging multimodal digital biomarkers into “Digital Neuro Fingerprints” for precision neurology in dementias: the promise of the right treatment for the right patient at the right time in the age of AI

Tarnanas, I., Seixas, A. A., Wyss, M., Vlamos, P., & Çöltekin, A. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1727707 · Cited by 3 · see citing works

Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer’s disease

Saguer, I. L., Gabriele, R. M. C., Bradshaw, T. Y., Leckey, C. A., Belder, C. R. S., Chávez‐Gutiérrez, L., de Silva, R., Fox, N. C., Wray, S., Oxtoby, N. P., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcag105 · Cited by 3 · see citing works

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

de Leeuw, S., & Tackenberg, C. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0161-0 · Cited by 31 · see citing works

The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling

Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24 · see citing works

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease

Marei, H., Khan, M. U. A., & Hasan, A. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00504-2 · Cited by 21 · see citing works

The postnatal development of corticospinal neurons in the rat

Ohtani, R., & Shirai, T. (1985) · Neuroscience Research · doi:10.1016/0168-0102(85)90107-5 · Cited by 1 · see citing works

Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem Cells

Ovchinnikov, D. A., & Wolvetang, E. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041357 · Cited by 13 · see citing works