Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek, Anna; Mihalik, Balázs; Avci, Hasan X.; Chandrasekaran, Abinaya; Téglási, Annamária; Bock, István; Giudice, Maria Lo; Táncos, Zsuzsanna; Molnár, Kinga; László, Lajos; Nielsen, Jørgen E.; Holst, Bjørn; Freude, Kristine; Hyttel, Poul; Kobolák, Julianna; Dinnyés, András

doi:10.1186/s13195-017-0317-z

Cited by 227Alzheimer's disease research and treatmentsPluripotent Stem Cells ResearchDementia and Cognitive Impairment Research

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

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Ochalek, Anna, Mihalik, Balázs, Avci, Hasan X., Chandrasekaran, Abinaya, Téglási, Annamária, Bock, István, Giudice, Maria Lo, Táncos, Zsuzsanna +8 more·2017·Alzheimer's Research & Therapy

DOI 10.1186/s13195-017-0317-zPMC PMC5709977

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Abstract

Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present study, our aim was to establish an in vitro cell model based on patient-specific human neurons to study the pathomechanism of sporadic AD. We compared neurons derived from induced pluripotent stem cell (iPSC) lines of patients with early-onset familial Alzheimer’s disease (fAD), all caused by mutations in the PSEN1 gene; patients with late-onset sporadic Alzheimer’s disease (sAD); and three control individuals without dementia. The iPSC lines were differentiated toward mature cortical neurons, and AD pathological hallmarks were analyzed by RT-qPCR, enzyme-linked immunosorbent assay, and Western blotting methods. Neurons from patients with fAD and patients with sAD showed increased phosphorylation of TAU protein at all investigated phosphorylation sites. Relative to the control neurons, neurons derived from patients with fAD and patients with sAD exhibited higher levels of extracellular amyloid-β 1–40 (Aβ 1–40 ) and amyloid-β 1–42 (Aβ 1–42 ). However, significantly increased Aβ 1–42 /Aβ 1–40 ratios, which is one of the pathological markers of fAD, were observed only in samples of patients with fAD. Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. Moreover, elevated sensitivity to oxidative stress, as induced by amyloid oligomers or peroxide, was detected in both fAD- and sAD-derived neurons. On the basis of the experiments we performed, we can conclude there is no evident difference except secreted Aβ 1–40 levels in phenotype between fAD and sAD samples. To our knowledge, this is the first study in which the hyperphosphorylation of TAU protein has been compared in fAD and sAD iPSC-derived neurons. Our findings demonstrate that iPSC technology is suitable to model both fAD and sAD and may provide a platform for developing new treatment strategies for these conditions.

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iPSC-derived neurons from individuals with AD exhibit increased production of Aβ42, active GSK-3β, phosphorylated tau, endosomal abnormalities, and oxidative stress.
“iPSC-derived neurons from individuals with AD exhibit increased production of Aβ42, active GSK-3β, phosphorylated tau, endosomal abnormalities, and oxidative stress (12–17)”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [15]
The Results report higher Aβ1–42, phosphorylated tau, and active GSK-3β in AD-derived neurons. The Background reports enlarged early endosomes in AD neurons from an earlier study. But this paper demonstrates greater sensitivity to induced oxidative stress, not that its untreated AD-derived neurons exhibit elevated oxidative stress. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Neurons derived from iPSCs obtained from sporadic AD cases show elevated Tau hyperphosphorylation, increased Aβ levels and GSK3β activation.
“neurons derived from iPSCs obtained from sporadic AD cases also show elevated Tau hyperphosphorylation, increased Aβ levels and GSK3β activation44.”
From PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures (2026) · cites this paper as [44]
Late-stage neuropathological features, such as formation of insoluble tau and neurodegeneration, have not been reported in iPSC-derived neurons from individuals with AD.
“but late-stage neuropathological features, such as formation of insoluble tau and neurodegeneration have not been reported.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [15]
The Discussion reports TAU hyperphosphorylation in AD iPSC-derived neurons but does not say whether insoluble TAU or late-stage neurodegeneration has been reported in such models. The Results report cell death after externally applied Aβ oligomers, which does not establish spontaneous late-stage neurodegeneration. Searches for insoluble TAU and late-stage neurodegeneration found no passage resolving the claim. (LLM, conf=0.70)
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[16]Ferreira ST Lourenco MV Oliveira MM De Felice FG Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease Front Cell Neurosci. 2015 9 191 26074767 PMC4443025

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Authors: Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, A., Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, J. E., Holst, B., Freude, K., Hyttel, P., Kobolák, J., & Dinnyés, A.
Affiliations: BioTalentum (Hungary) (HU)
University of Szeged (HU)
Eötvös Loránd University (HU)
University of Copenhagen (DK)
Bioneer (Denmark) (DK)
Magyar Agrár- és Élettudományi Egyetem (HU)
Corresponding author: Dinnyés, András
ORCID: Avci, Hasan X.
Chandrasekaran, Abinaya
Bock, István
Táncos, Zsuzsanna
Molnár, Kinga
László, Lajos
Nielsen, Jørgen E.
Holst, Bjørn
Freude, Kristine
Kobolák, Julianna
Dinnyés, András
Venue: Alzheimer's Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2017-12
Volume: 9
Issue: 1
Pages: 90-90
ISSN: 1758-9193 (ISSN-L)
DOI: 10.1186/s13195-017-0317-z
PMC: PMC5709977
OpenAlex: W2769598455
Cited by: 225
References: 104
Citations by year: 2026: 16 · 2025: 27 · 2024: 28 · 2023: 19 · 2022: 29 · 2021: 25 · 2020: 38 · 2019: 29 · 2018: 13
FWCI: 16.19
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Alzheimer s Research & Therapy (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
ELTE Digital Institutional Repository (EDIT) (Eötvös Loránd University) (submittedVersion, other-oa)
Funders: EU FP7, STEMMAD (PIAPP-GA-2012-324451)
EU FP7, EpiHealth (HEALTH-2012-F2-278418)
EU FP7, EpiHealthNet (PITN-GA-2012-317146)
Richter Gedeon Research Grant (RG-IPI-2013_TP7/026)
Innovation Fund Denmark (BrainStem 4108-00008B, NeuroStem 4096-00001B)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: sporadic Alzheimer's disease, familial Alzheimer's disease, iPSC-derived neurons, tau hyperphosphorylation, amyloid-beta, amyloid precursor protein, oxidative stress, amyloid oligomers
MeSH terms: Glycogen Synthase Kinase 3 beta, Alzheimer Disease, Animals, Cell Differentiation, Cell Line, Transformed, Gene Expression Regulation, Humans, Hydrogen Peroxide, Mutation, Nerve Tissue Proteins, Neurons, Phosphorylation, RNA, Messenger, Time Factors, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Oxidative Stress, Presenilin-1, Induced Pluripotent Stem Cells

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Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

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