The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches
Open accessAbstract
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization. As of 4 August 2020, more than 18 million confirmed infections had been reported globally. Most patients have mild symptoms, but some patients develop respiratory failure which is the leading cause of death among COVID-19 patients. Endothelial cells with high levels of angiotensin-converting enzyme 2 expression are major participants and regulators of inflammatory reactions and coagulation. Accumulating evidence suggests that endothelial activation and dysfunction participate in COVID-19 pathogenesis by altering the integrity of vessel barrier, promoting pro-coagulative state, inducing endothelial inflammation, and even mediating leukocyte infiltration. This review describes the proposed cellular and molecular mechanisms of endothelial activation and dysfunction during COVID-19 emphasizing the principal mediators and therapeutic implications.
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Cites
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Cited by
Singh, R., Rathore, S. S., Khan, H., Karale, S., Chawla, Y., Iqbal, K., Bhurwal, A., Tekin, A., Jain, N., Mehra, I., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.780872 · Cited by 193
Kandhaya‐Pillai, R., Yang, X., Tchkonia, T., Martin, G. M., Kirkland, J. L., & Oshima, J. (2022) · Aging Cell · doi:10.1111/acel.13646 · Cited by 119
“Endothelial cell injury coupled with excessive inflammation appears to be a key driver of COVID- 19 severity (Jin et al., 2020).”
BackgroundCell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
Li, X., Zhang, Z., Wang, Z., Gutiérrez-Castrellón, P., & Shi, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01043-6 · Cited by 67
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants
Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Luxán, G., Nicin, L., Aslan, G. S., Milting, H., Kandler, J. D., Dendorfer, A., Heumueller, A. W., et al. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00882-8 · Cited by 53
COVID-19 as a Risk Factor for Alzheimer’s Disease
Golzari-Sorkheh, M., Weaver, D. F., & Reed, M. A. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220800 · Cited by 39
Metadata
- Authors
- Jin, Y., Ji, W., Yang, H., Chen, S., Zhang, W., & Duan, G.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2020-12-24
- Volume
- 5
- Issue
- 1
- Pages
- 293-293
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3116488354
- Cited by
- 399
- References
- 17
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- gold
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