The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Open accessAbstract
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
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Cites
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“Through the identification of SARS-CoV2 proteins, researchers found ~24% difference in S between SARSCoV-2 and SARS-CoV, whereas that of RBD is ~23% [39].”
BackgroundCell entry mechanisms of SARS-CoV-2
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Cited by
Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines
Nance, K. D., & Meier, J. L. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00197 · Cited by 466
The variant gambit: COVID-19’s next move
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On the origin and evolution of SARS-CoV-2
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SARS-CoV-2 spreads through cell-to-cell transmission
Zeng, C., Evans, J. P., King, T., Zheng, Y.-M., Oltz, E. M., Whelan, S. P. J., Saif, L. J., Peeples, M. E., & Liu, S.-L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111400119 · Cited by 246
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Metadata
- Authors
- Huang, Y., Yang, C., Xu, X.-F., Xu, W., & Liu, S.-W.
- Venue
- Acta Pharmacologica Sinica
- Published
- 2020-08-03
- Volume
- 41
- Issue
- 9
- Pages
- 1141-1149
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- OpenAlex
- W3046463683
- Cited by
- 2,224
- References
- 14
- FWCI
- 50.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, Y., Yang, C., Xu, X.-F., Xu, W., & Liu, S.-W. (2020). Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica. https://doi.org/10.1038/s41401-020-0485-4
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