IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial pneumonia and has one of the poorest prognosis. However, the molecular mechanisms underlying IPF progression remain largely unknown. In this study, we determined that IL-24, an IL-20 subfamily cytokine member, was increased both in the serum of IPF patients and the bronchoalveolar lavage fluid (BALF) of mice following bleomycin (BLM)-induced pulmonary fibrosis. As a result, IL-24 deficiency protected mice from BLM-induced lung injury and fibrosis. Specifically, loss of IL-24 significantly attenuated transforming growth factor β1 (TGF-β1) production and reduced M2 macrophage infiltration in the lung of BLM-induced mice. Mechanistically, IL-24 alone did not show a perceptible impact on the induction of M2 macrophages, but it synergized with IL-4 to promote M2 program in macrophages. IL-24 suppressed IL-4-induced expression of suppressor of cytokine signaling 1 (SOCS1) and SOCS3, through which it enhanced signal transducer and activator of transcription 6/peroxisome proliferator-activated receptor gamma (STAT6/PPARγ) signaling, thereby promoting IL-4-induced production of M2 macrophages. Collectively, our data support that IL-24 synergizes with IL-4 to promote macrophage M2 program contributing to the development of pulmonary fibrosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IPF patients are predominantly infiltrated by M2 macrophages during disease progression.
“IPF patients are predominantly infiltrated by M2 macrophages during disease progression 12, 13.”
From Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice (2024) · cites this paper as [12]
Cites
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186 · see citing works
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · see citing works
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · see citing works
Richeldi, L., Collard, H. R., & Jones, M. G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30866-8 · Cited by 2,020 · see citing works
Clinical course and prediction of survival in idiopathic pulmonary fibrosis
Ley, B., Collard, H. R., & King, T. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201006-0894ci · Cited by 1,765 · see citing works
Martinez, F. J., Collard, H. R., Pardo, A., Raghu, G., Richeldi, L., Selman, M., Swigris, J. J., Taniguchi, H., & Wells, A. U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.74 · Cited by 1,388 · see citing works
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization
Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., & Tsatsanis, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601515 · Cited by 1,148 · see citing works
Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review
Hutchinson, J., Fogarty, A., Hubbard, R., & McKeever, T. M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00185114 · Cited by 913 · see citing works
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
Rutz, S., Wang, X., & Ouyang, W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3766 · Cited by 410 · see citing works
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Zhang, L., Wang, Y., Wu, G., Xiong, W., Gu, W., & Wang, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0864-2 · Cited by 368 · see citing works
Self-citationCelada, L. J., Kropski, J. A., Herazo‐Maya, J. D., Luo, W., Creecy, A., Abad, A. T., Chioma, O. S., Lee, G., Hassell, N. E., Shaginurova, G. I., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar8356 · Cited by 367 · see citing works
Self-citationThe Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages
Yu, X., Buttgereit, A., Lelios, I., Utz, S. G., Cansever, D., Becher, B., & Greter, M. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.007 · Cited by 346 · see citing works
Pechkovsky, D. V., Prasse, A., Kollert, F., Engel, K. M., Dentler, J., Luttmann, W., Friedrich, K., Müller–Quernheim, J., & Zissel, G. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.06.017 · Cited by 328 · see citing works
The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis
Desai, O., Winkler, J., Minasyan, M., & Herzog, E. L. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00043 · Cited by 314 · see citing works
Yao, Y., Wang, Y., Zhang, Z., He, L., Zhu, J., Zhang, M., He, X., Cheng, Z., Ao, Q., Cao, Y., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.36 · Cited by 235 · see citing works
Self-citationEpidemiology and survival of idiopathic pulmonary fibrosis from national data in Canada
Hopkins, R. B., Burke, N., Fell, C. D., Dion, G., & Kolb, M. R. J. (2016) · European Respiratory Journal · doi:10.1183/13993003.01504-2015 · Cited by 181 · see citing works
Kumari, S., Bonnet, M., Ulvmar, M. H., Wolk, K., Karagianni, N., Witte, E., Uthoff‐Hachenberg, C., Renauld, J., Kollias, G. A., Toftgård, R., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.009 · Cited by 170 · see citing works
IL-22 promotes fibroblast-mediated wound repair in the skin
McGee, H. M., Schmidt, B. A., Booth, C. J., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S., Flavell, R. A., & Horsley, V. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.463 · Cited by 161 · see citing works
MDA-7/IL-24: Multifunctional Cancer Killing Cytokine
Menezes, M. E., Bhatia, S., Bhoopathi, P., Das, S. K., Emdad, L., Dasgupta, S., Dent, P., Wang, X., Sarkar, D., & Fisher, P. B. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4471-6458-6_6 · Cited by 118 · see citing works
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice
Lu, J., Xie, L., Liu, C., Zhang, Q., & Sun, S. (2017) · Scandinavian Journal of Immunology · doi:10.1111/sji.12545 · Cited by 112 · see citing works
Shan, M., Qin, J., Jin, F., Han, X., Guan, H., Li, X., Zhang, J., Zhang, H., & Wang, Y. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.021 · Cited by 112 · see citing works
Self-citationYoung, L. R., Gulleman, P. M., Short, C. W., Tanjore, H., Sherrill, T., Qi, A., McBride, A. P., Zaynagetdinov, R., Benjamin, J. T., Lawson, W. E., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88947 · Cited by 105 · see citing works
Interleukin‐24 and its receptors
Wang, M., & Liang, P. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02094.x · Cited by 103 · see citing works
Liu, P., Miao, K., Zhang, L., Mou, Y., Xu, Y., Xiong, W., Yu, J., & Wang, Y. (2020) · Respiratory Research · doi:10.1186/s12931-020-1300-y · Cited by 94 · see citing works
Self-citationDocosahexaenoic acid enhances M2 macrophage polarization via the p38 signaling pathway and autophagy
Kawano, A., Ariyoshi, W., Yoshioka, Y., Hikiji, H., Nishihara, T., & Okinaga, T. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28527 · Cited by 92 · see citing works
Wang, Y., Zhu, J., Zhang, L., Zhang, Z., He, L., Mou, Y., Deng, Y., Cao, Y., Yang, P. C., Su, Y., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.024 · Cited by 91 · see citing works
Self-citationShefler, I., Pasmanik‐Chor, M., Kidron, D., Mekori, Y. A., & Hershko, A. Y. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.035 · Cited by 84 · see citing works
Decreased production of TGF-β 1 by human alveolar macrophages compared with blood monocytes
Toossi, Z., Hirsch, C. S., Hamilton, B. D., Knuth, C. K., Friedlander, M. A., & Rich, E. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.9.3461 · Cited by 78 · see citing works
Involvement of JNK signaling in IL4-induced M2 macrophage polarization
Hao, J., Hu, Y., Li, Y., Zhou, Q., & Lv, X. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.010 · Cited by 74 · see citing works
Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung
Leppäranta, O., Sens, C., Salmenkivi, K., Kinnula, V. L., Keski‐Oja, J., Myllärniemi, M., & Koli, K. M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1385-9 · Cited by 73 · see citing works
Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells
Poindexter, N. J., Walch, E. T., Chada, S., & Grimm, E. A. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0205116 · Cited by 68 · see citing works
Poindexter, N. J., Williams, R. R., Powis, G., Jen, E. Y., Caudle, A. S., Chada, S., & Grimm, E. A. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01077.x · Cited by 63 · see citing works
Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation
Wei, Q., Sha, Y., Bhattacharya, A., Fattah, E. A., Bonilla, D., Jyothula, S., Pandit, L. M., Hershey, G. K. K., & Eissa, N. T. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201305-0874oc · Cited by 62 · see citing works
Cui, Z., Liao, J., Cheong, N., Longoria, C., Cao, G., DeLisser, H. M., & Savani, R. C. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.08.002 · Cited by 59 · see citing works
Miao, K., Pan, T. S., Mou, Y., Zhang, L., Xiong, W., Xu, Y., Yu, J., & Wang, Y. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320940185 · Cited by 55 · see citing works
Self-citationGuo, Y., Zhang, M., Wang, F., Pei, G., Sun, F., Zhang, Y., He, X., Wang, Y., Song, J., Zhu, F., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.04.007 · Cited by 46 · see citing works
Self-citationIL-24 is Expressed by Rat and Human Macrophages
Garn, H. (2002) · Immunobiology · doi:10.1078/0171-2985-00135 · Cited by 45 · see citing works
Schwegmann, A., Guler, R., Cutler, A. J., Arendse, B., Horsnell, W. G. C., Flemming, A., Kottmann, A. H., Ryan, G. R., Hide, W., Leitges, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703496104 · Cited by 41 · see citing works
Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity
Burgy, O., Wettstein, G., Bellaye, P., Décologne, N., Racoeur, C., Goirand, F., Beltramo, G., Hernandez, J., Kénani, A., Camus, P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7785 · Cited by 38 · see citing works
Wang, Q., Yu, J., Hu, Y., Chen, X., Zhang, L., Pan, T. S., Miao, K., Mou, Y., Xu, Y., Xiong, W., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110715 · Cited by 37 · see citing works
Self-citationHu, Y., Yu, J., Wang, Q., Zhang, L., Chen, X., Cao, Y., Zhao, J., Xu, Y., Jiang, D., Wang, Y., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.01.010 · Cited by 36 · see citing works
Self-citationDeficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
Sun, P., Li, L., Zhao, C., Pan, M., Qian, Z., & Su, X. (2017) · Molecular Medicine · doi:10.2119/molmed.2016.00083 · Cited by 33 · see citing works
Steinert, A., Linas, I., Kaya, B., Ibrahim, M. A., Schlitzer, A., Hruz, P. L., Radulovic, K., Terracciano, L., Macpherson, A. J., & Niess, J. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700350 · Cited by 33 · see citing works
Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver
Wang, J., Hu, B., Zhao, Z., Zhang, H., Zhang, H., Zhao, Z., Ma, X., Shen, B., Sun, B., Huang, X., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-019-2209-6 · Cited by 25 · see citing works
Self-citationNoskovičová, N., Heinzelmann, K., Burgstaller, G., Behr, J., & Eickelberg, O. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00205.2017 · Cited by 17 · see citing works
Inomata, M., Into, T., Nakashima, M., Noguchi, T., & Matsushita, K. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.02.015 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 466 · see citing works
Self-citationIdiopathic Pulmonary Fibrosis: An Update on Pathogenesis
Mei, Q., Liu, Z., Zuo, H., Yang, Z., & Qu, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797292 · Cited by 360 · see citing works
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 353 · see citing works
The Bigger Picture: Why Oral Mucosa Heals Better Than Skin
Waasdorp, M., Krom, B. P., Bikker, F. J., van Zuijlen, P. P. M., Niessen, F. B., & Gibbs, S. (2021) · Biomolecules · doi:10.3390/biom11081165 · Cited by 216 · see citing works
Marrocco, A., & Ortiz, L. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936167 · Cited by 166 · see citing works
Immune Mechanisms of Pulmonary Fibrosis with Bleomycin
Ishida, Y., Kuninaka, Y., Mukaida, N., & Kondo, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043149 · Cited by 123 · see citing works
Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling
Hu, Y., Wang, Q., Yu, J., Zhou, Q., Deng, Y., Liu, J., Zhang, L., Xu, Y., Xiong, W., & Wang, Y. (2022) · Nature Communications · doi:10.1038/s41467-021-27684-9 · Cited by 76 · see citing works
Self-citationYang, X., Liu, Z., Zhou, J., Guo, J., Han, T., Liu, Y., Li, Y., Bai, Y., Xing, Y., Wu, J., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5413 · Cited by 71 · see citing works
Wang, Q., Liu, J., Hu, Y., Pan, T. S., Xu, Y., Yu, J., Xiong, W., Zhou, Q., & Wang, Y. (2021) · Theranostics · doi:10.7150/thno.61085 · Cited by 70 · see citing works
Self-citationZhou, B., Liu, H., Xu, F., & Jia, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01557-2 · Cited by 71 · see citing works
Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases
Zhong, Y., Zhang, X., & Chong, W. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020627 · Cited by 61 · see citing works
TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization
Luo, Q., Deng, D., Li, Y., Shi, H., Zhao, J., Qian, Q., Wang, W., Cai, J., Yu, W., & Liu, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110070 · Cited by 61 · see citing works
Self-citationMacrophage polarization in tissue fibrosis
Yang, H.-D., Cheng, H., Dai, R., Shang, L., Zhang, X., & Wen, H.-Y. (2023) · PeerJ · doi:10.7717/peerj.16092 · Cited by 61 · see citing works
Sun, A. R., Ramli, M. F. H., Shen, X., Ramakanth, K. K., Chen, D., Hu, Y., Vidyasekar, P., Foo, R., Long, Y., Zhu, J., et al. (2025) · Nature Materials · doi:10.1038/s41563-025-02234-6 · Cited by 57 · see citing works
Chen, Y., Wang, T., Liang, F., Han, J., Lou, Z., Yu, Y., Li, J., Zhan, T., Gu, Y., Dong, L., et al. (2024) · Theranostics · doi:10.7150/thno.94482 · Cited by 56 · see citing works
“IPF patients are predominantly infiltrated by M2 macrophages during disease progression [12, 13].”
BackgroundSelf-citationFeng, K.-N., Meng, P., Zou, X., Zhang, M., Li, H., Yang, H., Li, H., & Zhang, T. (2022) · Respiratory Research · doi:10.1186/s12931-022-02167-7 · Cited by 55 · see citing works
Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways
Pokhreal, D., Crestani, B., & Helou, D. G. (2023) · Cells · doi:10.3390/cells12172193 · Cited by 52 · see citing works
Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis
Ma, H., Liu, S., Li, S., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918771 · Cited by 51 · see citing works
Dong, S., Fang, H., Zhu, J., Wu, Z., Liu, Y., Zhu, J., Ma, B., Chen, Q., & Yang, Y. (2025) · ACS Nano · doi:10.1021/acsnano.4c15130 · Cited by 51 · see citing works
SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress
Luo, J., Li, P., Dong, M., Zhang, Y., Lu, S., Chen, M., Zhou, H., Lin, N., Jiang, H., & Wang, Y. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01266-w · Cited by 44 · see citing works
Self-citationSchisandrin B protects against LPS-induced inflammatory lung injury by targeting MyD88
Zhu, W., Luo, W., Han, J., Zhang, Q., Ji, L., Самородов, А. В., Павлов, В. Н., Zhuang, Z., Yang, D., Yin, L., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154489 · Cited by 38 · see citing works
Self-citationLuo, L., Zhuang, X., Fu, L., Dong, Z., Yi, S., Wang, K., Jiang, Y., Zhao, J., Yang, X., & Hei, F. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70098 · Cited by 37 · see citing works
Self-citationLiu, B., Jiang, J., Liang, H., Xiao, P., Lai, X., Nie, J., Yu, W., Gao, Y., & Wen, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107907 · Cited by 36 · see citing works
Choi, S. M., Mo, Y., Bang, J., Ko, Y. G., Ahn, Y. H., Kim, H. Y., Koh, J., Yim, J., & Kang, H. (2023) · Respiratory Research · doi:10.1186/s12931-023-02357-x · Cited by 34 · see citing works
Li, C., Feng, X., Li, S., He, X., Luo, Z., Cheng, X., Yao, J., Xiao, J., Wang, X., Wen, D., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.022 · Cited by 29 · see citing works
Wang, Y., Wu, G., Yue, H., Zhou, Q. T., Zhang, L., He, L., Gu, W., Gao, R., Dong, L., Zhang, H., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.017 · Cited by 30 · see citing works
Self-citationGupta, A. A., Sasse, S. K., Gruca, M. A., Sanford, L., Dowell, R. D., & Gerber, A. N. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101147 · Cited by 29 · see citing works
USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis
Xu, Y., Liu, J., Wang, J., Wang, J., Lan, P., & Wang, T. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.99345 · Cited by 28 · see citing works
Self-citationInterleukin-24 regulates mucosal remodeling in inflammatory bowel diseases
Ónódy, A., Veres-Székely, A., Pap, D., Rokonay, R., Szebeni, B., Sziksz, E., Oswald, F., Veres, G., Cseh, Á., Szabo, A. J., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02890-7 · Cited by 27 · see citing works
IL-24 improves efficacy of CAR-T cell therapy by targeting stemness of tumor cells
Zhang, K., Hu, W., Li, F., Wen, C., Zhou, L., Zhang, L., Lian, J., Liu, S., Wang, S., & Zhang, Y. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02601-1 · Cited by 27 · see citing works
Self-citationMacrophages: A rising star in immunotherapy for chronic pancreatitis
Xiang, H., Yu, H. N., Zhou, Q., Wu, Y., Ren, J., Zhao, Z., Tao, X., & Dong, D. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106508 · Cited by 26 · see citing works
Wu, Z., Shi, R., Yan, S., Zhang, S., Lü, B., Huang, Z., & Ji, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155368 · Cited by 25 · see citing works
Self-citationYan, L., Hou, C., Liu, J., Wang, Y., Zeng, C., Yu, J., Zhou, T., Zhou, Q., Duan, S., & Xiong, W. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2314-8 · Cited by 26 · see citing works
Self-citationNie, Y., Li, J., Zhai, X., Wang, Z., Wang, J., Wu, Y., Zhao, P., & Yan, G. (2023) · Antioxidants · doi:10.3390/antiox12122022 · Cited by 25 · see citing works
Self-citationLi, Y., Yin, H., Yuan, H., Wang, E., Wang, C., Li, H., Geng, X., Zhang, Y., & Bai, J. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03260-x · Cited by 24 · see citing works
Self-citationLiu, Y., Wang, D., Liu, X., Yuan, H., Liu, D., Hu, Y., & Ning, S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01966-3 · Cited by 23 · see citing works
Arginine is a key player in fibroblasts during the course of IPF development
Wang, Y., Zhao, J., Zhang, H., & Wang, C. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.023 · Cited by 23 · see citing works
Self-citationWei, W., Ning, C., Huang, J., Wang, G., Lai, J., Han, J., He, J., Zhang, H., Liang, B., Liao, Y., et al. (2021) · Virulence · doi:10.1080/21505594.2021.1958470 · Cited by 22 · see citing works
Self-citationIL-22, a vital cytokine in autoimmune diseases
Li, J., Wu, Z., Wu, Y., Hu, X., Yang, J., Zhu, D., Wu, M., Li, X., Bentum‐Ennin, L., & Hu, W. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae035 · Cited by 21 · see citing works
Self-citationAlbendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
Zeng, C., Yue, H., Wang, C., Ju, X., Wang, T., Fu, X., Zhou, Q., Zhang, H., He, L., Yu, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05655-0 · Cited by 21 · see citing works
Self-citationDectin-1 facilitates lung fungal-mediated pulmonary fibrosis
Qiu, D., Zhang, S., Huang, C., Wang, X., Deng, J., Sun, H., Feng, B., Tan, Y. C., Ji, K., Xu, S., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.007 · Cited by 20 · see citing works
Self-citationMMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization
Chang, L., Gao, J., Yu, Y., Liao, B., Zhou, Y., Zhang, J., Ma, X., Hou, W., Zhou, T., & Xu, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111045 · Cited by 20 · see citing works
Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production
He, J., Du, Y. J., Li, G., Xiao, P., Sun, X., Song, W., Lai, L., Meng, X., Zhang, J., & Wang, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.760138 · Cited by 20 · see citing works
Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance
Yan, R., Li, Y., Chen, S., Zhu, L., Zhou, C., Chen, J., Zou, S., & Han, X. (2025) · Advanced Science · doi:10.1002/advs.202512164 · Cited by 20 · see citing works
Wang, Y., Li, X., Pu, S., Wang, X. D., Guo, L., Zhang, L., & Wang, Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3541731 · Cited by 18 · see citing works
Self-citationZeng, C., Wang, Q., Liu, X., Wang, K., Wang, C., Ju, X., Wang, T., Zhou, Q., Fu, X., Yu, J., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s444470 · Cited by 18 · see citing works
Self-citationImmune-epithelial cell interactions in lung development, homeostasis and disease
Yoshida, M., Arzili, R., & Nikolić, M. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106703 · Cited by 16 · see citing works
Wang, S., Hu, G., Chen, L., Ma, K., Hu, C., Zhu, H., Xu, N., Zhou, C., & Liu, M. (2022) · Cell Biology International · doi:10.1002/cbin.11952 · Cited by 18 · see citing works
Self-citationBu, N., Wang, S., Ma, Y., Xia, H., Zhao, Y., Shi, X., Liu, Q., Wang, S., & Gao, Y. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad107 · Cited by 17 · see citing works
Capturing the multifaceted function of adipose tissue macrophages
Matz, A. J., Qu, L., Karlinsey, K., Vella, A. T., & Zhou, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148188 · Cited by 16 · see citing works
Mechanisms of fibrosis in iatrogenic laryngotracheal stenosis: New discoveries and novel targets
Xu, M., Hu, B., Chen, J., Wang, J., & Li, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115995 · Cited by 16 · see citing works
Jiang, Y., Wang, N., Liu, J., Ren, H., Jiang, W., Lei, Y., Fu, X., Hao, M., Lang, X., Liu, Y., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04172-1 · Cited by 16 · see citing works
Treating Pulmonary Fibrosis with Non-Viral Gene Therapy: From Bench to Bedside
Huang, T., Gao, J. L., Cai, L., Xie, H., Wang, Y., Wang, Y., & Zhou, Q. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040813 · Cited by 16 · see citing works
Self-citationThe role of macrophages in renal fibrosis and therapeutic prospects
Niu, D., Yang, J. J., & He, D. (2025) · PeerJ · doi:10.7717/peerj.19769 · Cited by 15 · see citing works
Transcriptome analysis identifies IL24 as an autophagy modulator in PM2.5 caused lung dysfunction
Liu, Y., He, X., Liu, J., Zhang, L., Xiong, A., Wang, J., Liu, S., Jiang, M., Luo, L., Xiong, Y., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114039 · Cited by 15 · see citing works
Self-citationYang, Y., Xiao, Z., Yang, W., Sun, Y., Sui, X. Y., Lin, X., Yang, X., Bao, Z., Cui, Z., Ma, Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05219-x · Cited by 15 · see citing works
Self-citationWu, G., Zhou, M., Wang, Y., Zhou, Q., Zhang, L., He, L., Zhang, S., Yu, Q., Xu, Y., Zhao, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.930103 · Cited by 15 · see citing works
Self-citationCai, Y., He, C., Dai, Y., Zhang, D., Lv, G., Lu, H., & Chen, G. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114643 · Cited by 14 · see citing works
Wu, Y., He, S., Zhang, Y., Li, S., Liu, R., Zhang, Y., Jing, Y., Chen, D., Tong, Y., Wang, Z., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155846 · Cited by 14 · see citing works
Jung, W., Yang, M., Kang, M.-S., Pyo, G., Choi, H., Li, K., & Park, E. (2024) · Toxicology · doi:10.1016/j.tox.2024.153877 · Cited by 14 · see citing works
Wang, J., Ren, Y., Zheng, X., Kang, J., Huang, Z., Xu, L., & Wang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.675907 · Cited by 14 · see citing works
Self-citationPolyhexamethylene guanidine phosphate-induced necrosis may be linked to pulmonary fibrosis
Kang, M.-S., Kim, S., Yang, M., Kim, H.-Y., Kim, I.-H., Kang, J. W., Choi, H. S., Jin, S.-W., & Park, E. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.03.009 · Cited by 13 · see citing works
Wu, Y., Hsing, C., Chiu, C.-J., Chiang, B., & Hsu, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-64302-4 · Cited by 12 · see citing works
Zhang, M., Liu, S., Wu, Z., Wang, C., Zhang, H., Yang, J., Guo, C., Dai, M., Wang, X.-F., & Ren, W. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-2999-1 · Cited by 11 · see citing works
Self-citationNovel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases
Feng, K., Cen, J., Zou, X., & Zhang, T. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110322 · Cited by 10 · see citing works
Advances in understanding the role of interleukins in pulmonary fibrosis (Review)
He, Y., Shen, X., Zhai, K., & Nian, S. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12775 · Cited by 10 · see citing works
Xu, L., Zhang, Y., Dai, Q., Lin, N., Guan, T., Song, X., & Hong, S. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101939 · Cited by 10 · see citing works
Fang, H., Zheng, H., Jiaqi, W., Dong, T., Yiyuanzi, Z., Qiwen, Y., Ying, L., Hongchun, Z., & Liu, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1258885 · Cited by 10 · see citing works
Panda, B., Chilvery, S., Devi, P., Kalmegh, R., & Godugu, C. (2025) · Life Sciences · doi:10.1016/j.lfs.2024.123354 · Cited by 9 · see citing works
Sun, H., Ma, D.-Y., Guo, X.-Y., Hao, Y., Jin, M.-H., Han, Y., Jin, X., & Kwon, T. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02039-7 · Cited by 9 · see citing works
Nie, Z.-Q., Wu, J., Xie, J., & Yin, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33314 · Cited by 8 · see citing works
Diagnostic and predictive values of m5C‑associated genes in idiopathic pulmonary fibrosis
Tian, L., Song, W., Wu, J., Lan, Y., & Chen, L. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13418 · Cited by 8 · see citing works
Self-citationTu, Y., Yang, Z., He, Y., Wang, T., Hua, P., Yao, Q., & Gu, H. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-04060-x · Cited by 8 · see citing works
Chen, S., Chen, Z., Zhou, B., Chen, Y., Huang, Y., Cao, J. P., Shen, L., & Zheng, Y. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011299 · Cited by 10 · see citing works
IL-32–producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis
Dey, N. S., Dey, S., Brown, N., Senarathne, S., Reis, L. C., Sengupta, R., Lindoso, J. Â. L., James, S. R., Gilbert, L., Boucher, D., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci182040 · Cited by 10 · see citing works
Zhang, X., Zhu, J., Yang, S., Yao, Z., Zhao, S., Wāng, Y., Zhou, C., Zhu, Q., & Shen, T. (2022) · Environmental Science Nano · doi:10.1039/d2en00581f · Cited by 8 · see citing works
Shibata, N., Ohashi, Y., Tsukada, A., Iwase, D., Aikawa, J., Mukai, M., Metoki, Y., Uekusa, Y., Satoh, M., Inoue, G., et al. (2024) · Medicina · doi:10.3390/medicina60050741 · Cited by 7 · see citing works
Tian, L., Jin, J., Lai, F., Yao, S., Zhang, Y., Liu, J., Zhang, H., Lu, Q., Liu, C., Tian, S., et al. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137381 · Cited by 7 · see citing works
Self-citationLi, Y., Xiao, G., Fu, X., Luo, X., Yang, F., Li, Y., & Zheng, Z. (2025) · Immunobiology · doi:10.1016/j.imbio.2025.152908 · Cited by 7 · see citing works
Li, C., Zhang, H., Liu, Y., Zhang, T., & Gu, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-02447-4 · Cited by 7 · see citing works
Self-citationLysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis
Tian, K., Yu, M., Jiang, M., Gao, Z., Zheng, D., Shi, W., Cheng, D., & Zhao, X. (2025) · Comprehensive physiology · doi:10.1002/cph4.70023 · Cited by 7 · see citing works
Yuan, Z., & Li, M. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.106052 · Cited by 7 · see citing works
Jiang, Y., Zhang, Y., Wang, X., Xiang, Y., Wang, Z., Wang, B., Ding, Y., Gao, Y., Rui, B., Bai, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115399 · Cited by 6 · see citing works
Comparison of disinfectants-induced gene expression profile: Potential adverse effects
Park, E., Jin, S.-W., Shim, I., & Cho, A. E. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116546 · Cited by 6 · see citing works
Anti‐aging and rejuvenating effects and mechanism of Dead Sea water in skin
Yan, X., Bao, X., Cheng, S., Ba, Q., Chang, J., Zhou, K., & Yan, X. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12931 · Cited by 6 · see citing works
He, L., Lv, Q., Luo, J., Guo, Y., Sun, H., Zong, M., & Fan, L. (2025) · Immunology Letters · doi:10.1016/j.imlet.2025.107006 · Cited by 6 · see citing works
Qiu, Y., Liu, C. X., Shi, Y., Hao, N., Tan, W., & Wang, F. (2023) · BMC Genomics · doi:10.1186/s12864-023-09548-2 · Cited by 6 · see citing works
Self-citationKotani, T., Ikemoto, M., Matsuda, S., Masutani, R., & Takeuchi, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179669 · Cited by 6 · see citing works
Wang, C., Chen, Y., Huang, H., Yuan, Z., Dong, Y., Jin, J., Long, J., Liu, L., Fan, L., & Xiang, R. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01119-3 · Cited by 5 · see citing works
Self-citationThe Trm-Treg Axis as a tissue-encoded immune checkpoint in chronic inflammation and autoimmunity
Li, L., Xia, Y., & Liu, Y. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103977 · Cited by 5 · see citing works
Fu, C., Cao, Y., Mei, Y., Xiao, Q., Hu, J., Gao, Z., Gao, X., Hou, Y., Zhang, F., Zhu, G., et al. (2026) · Advanced Functional Materials · doi:10.1002/adfm.202529034 · Cited by 5 · see citing works
Tukhovskaya, E. A., Palikova, Y. A., Severyukhina, M. S., Ismailova, A. M., Паликов, В. А., Слащева, Г. А., Borozdina, N. A., Mikhaylov, E. S., Kravchenko, I. N., Kazakov, V. A., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17101360 · Cited by 5 · see citing works
Feng, X., Lu, J., Cheng, W., Zhao, P., Chang, X., & Wu, J. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156905 · Cited by 5 · see citing works
MEGF6 prevents sepsis-induced acute lung injury in mice
Liang, H., Liu, G., Zeng, W., Fan, Q., Nie, Z., Hu, H., Zhang, R., & Xie, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110727 · Cited by 5 · see citing works
Chen, Y.-L., Li, Y., He, Y., Shen, L., Fu, S., Qiao, L., Ran, Y., Li, J., Zhao, Y., Gao, J., et al. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105710 · Cited by 5 · see citing works
Self-citationSTAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway
Yang, Y., Li, Q., Wei, S., Chu, K., Xue, L., Liu, J., Ma, Y., & Tao, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2485250 · Cited by 5 · see citing works
Chen, J., Zou, P., Li, Q., Gong, C., Fang, Z., Lin, B., Lang, J., & Chen, M. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119026 · Cited by 4 · see citing works
Zhang, Y., Sun, D., Song, Y., & Ye, Q. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03392-0 · Cited by 4 · see citing works
Pirfenidone combined with UC-MSCs reversed bleomycin-induced pulmonary fibrosis
Xu, J., Abudureheman, Z., Gong, H., Zhong, X., Xue, L., Zou, X., & Li, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-14286-4 · Cited by 4 · see citing works
Dey, N. S., Dey, S., Brown, N., Senarathne, S., Reis, L. C., Sengupta, R., Lindoso, J. Â. L., James, S. R., Gilbert, L., Chatterjee, M., et al. (2024) · medRxiv · doi:10.1101/2024.01.02.23300281 · Cited by 4 · see citing works
- Authors
- Rao, L.-Z., Wang, Y., Zhang, L., Wu, G., Zhang, L., Wang, F.-X., Chen, L.-M., Sun, F., Jia, S., Zhang, S., Yu, Q., Wei, J.-H., Lei, H.-R., Yuan, T., Li, J., Huang, X., Cheng, B., Zhao, J., Xu, Y., Mo, B.-W., Wang, C.-Y., & Zhang, H.
- Affiliations
- Tongji Hospital (CN)
- Guilin Medical University (CN)
- Central South University (CN)
- ShanghaiTech University (CN)
- Corresponding author
- Wang, Yi
- Wang, Cong-Yi
- Zhang, Huilan
- ORCID
- Venue
- Cell Death & Differentiation
- Published
- 2020-11-03
- Volume
- 28
- Issue
- 4
- Pages
- 1270-1283
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC8027679
- OpenAlex
- W3095707317
- Cited by
- 153
- References
- 48
- Citations by year
- 2026: 24 · 2025: 37 · 2024: 39 · 2023: 21 · 2022: 22 · 2021: 9
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-01-05)
- Open access
- bronze
- doi.org
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81530024)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- IL-24, idiopathic pulmonary fibrosis, bleomycin-induced lung fibrosis, M2 macrophages, IL-4, SOCS1, SOCS3, TGF-β1, macrophage polarization, pulmonary fibrosis
- MeSH terms
- Interleukin-24, Animals, Bleomycin, Disease Models, Animal, Female, Humans, Interleukins, Macrophages, Male, Mice, Inbred C57BL, Pulmonary Fibrosis, Signal Transduction, Interleukin-4, Mice, Knockout, Mice, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review