Cited by 540Ferroptosis and cancer prognosisCancer-related Molecular PathwaysCell death mechanisms and regulation

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

p53 in ferroptosis regulation: the new weapon for the old guardian

Open access

Liu, Yanqing, Gu, Wei·2022·Cell Death & Differentiation

DOI 10.1038/s41418-022-00943-yPMC PMC9091200

Open this paper in CoChat — free account Open PDF

Abstract

Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41418-022-00943-y

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death
Ma, S., Sun, L., Wu, W., Jiang-li, W., Sun, Z., & Ren, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.551318 · Cited by 202
Retracted
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Self-citation
FSP1 is a glutathione-independent ferroptosis suppressor
Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341

Show all 141 references

Research works printed but not linked: 1

Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520:57–62. · DOI · Paper page

Sorted by citations

Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions
Lei, G., Zhuang, L., & Gan, B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.011 · Cited by 635
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 546
Self-citation
Understanding the complexity of p53 in a new era of tumor suppression
Liu, Y., Su, Z., Tavana, O., & Gu, W. J. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.04.009 · Cited by 538
Self-citation
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
Chen, X., Zhang, T., Su, W., Dou, Z., Zhao, D., Jin, X., Lei, H., Wang, J., Xie, X., Cheng, B., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05408-1 · Cited by 494
GPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 474
Self-citation
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks
Li, J., Jia, Y., Ding, Y.-X., Bai, J., Cao, F., & Li, F. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83348 · Cited by 417
Overcoming cancer chemotherapy resistance by the induction of ferroptosis
Wang, Y., Wu, X., Zhao, R., Li, Y., Zou, W., Chen, J., & Wang, H. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100916 · Cited by 370
Recent progress in ferroptosis: inducers and inhibitors
Du, Y., & Guo, Z. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01297-7 · Cited by 342
Cuproptosis: p53-regulated metabolic cell death?
Chen, X., Ling, H., Hao, Q., & Zhou, X. Y. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01125-0 · Cited by 289
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond
Mao, C., Wang, M., Zhuang, L., & Gan, B. (2024) · Protein & Cell · doi:10.1093/procel/pwae003 · Cited by 237
PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
Shen, L., Zhang, J., Zheng, Z., Yang, F., Liu, S., Wu, Y., Chen, Y., Xu, T., Mao, S., Yan, Y., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.74546 · Cited by 176
Roles of reactive oxygen species in inflammation and cancer
Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 180
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
Zhou, S., Liu, J., Wan, A., Zhang, Y., & Qi, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01545-6 · Cited by 175
Ferroptosis and the bidirectional regulatory factor p53
Xu, R., Wang, W., & Zhang, W. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01517-8 · Cited by 163
Glutathione metabolism in ferroptosis and cancer therapy
Xue, X., Wang, M., Cui, J., Yang, M., Ma, L., Kang, R., Tang, D., & Wang, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217697 · Cited by 168
Insights on the crosstalk among different cell death mechanisms
Eskander, G., AbdelHamid, S. G., Wahdan, S. A., & Radwan, S. M. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02328-9 · Cited by 150
Ferroptosis: Mechanisms and role in diabetes mellitus and its complications
Liu, P., Zhang, Z., Cai, Y., Li, Z., Zhou, Q., & Chen, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102201 · Cited by 137
Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species
Ju, S., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Choe, W., Yoon, K., Yeo, S. G., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212387 · Cited by 133
The mechanisms of ferroptosis and its role in alzheimer’s disease
Ma, H., Dong, Y., Chu, Y., Guo, Y., & Li, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.965064 · Cited by 115
Ferroptosis in heart failure
Yang, X., Kawasaki, N. K., Min, J., Matsui, T., & Wang, F. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.10.004 · Cited by 117
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
Koeberle, S. C., Kipp, A. P., Stuppner, H., & Koeberle, A. (2023) · Medicinal Research Reviews · doi:10.1002/med.21933 · Cited by 117
The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis
Guo, R., Duan, J., Pan, S., Cheng, F., Qiao, Y., Feng, Q., Liu, D., & Liu, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05969-9 · Cited by 108
Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
Xiao, J., Luo, C., Li, A., Cai, F.-L., Wang, Y., Pan, X., Liu, X., Wang, Z., Xing, Z., Yu, L., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112010 · Cited by 108
Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation
Liu, D., Qin, H., Gao, Y., Sun, M., & Wang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107258 · Cited by 94
Ferroptosis and Senescence: A Systematic Review
Coradduzza, D., Congiargiu, A., Chen, Z., Zinellu, A., Carru, C., & Medici, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043658 · Cited by 93
Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy
Liu, Q., Zhao, Y., Zhou, H., & Chen, C. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad004 · Cited by 94
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases
Feng, Q., Yang, Y., Ren, K., Qiao, Y., Sun, Z., Pan, S., Liu, F., Liu, Y., Huo, J., Liu, D., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85674 · Cited by 94
Self-citation
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
Xing, N., Du, Q., Guo, S., Xiang, G., Zhang, Y., Meng, X., Li, X., & Wang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01407-z · Cited by 91
p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases
Liu, Y., Stockwell, B. R., Jiang, X., & Gu, W. J. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00842-3 · Cited by 100
Self-citation
Ferroptosis in inflammatory arthritis: A promising future
Chang, S., Tang, M., Zhang, B., Xiang, D., & Li, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955069 · Cited by 91
Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment
Wang, W., Zhang, J., Wang, Y., Xu, Y., & Zhang, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.06.046 · Cited by 85
Ferroptosis: A double-edged sword
Wang, S., Guo, Q., Zhou, L., & Xia, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02037-9 · Cited by 98
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Li, J., Zheng, S., Fan, Y., & Tan, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06144-w · Cited by 82
Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases
Guo, D., Liu, Z., Zhou, J., Ke, C., & Li, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189947 · Cited by 83
SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
Su, H., Cantrell, A. C., Chen, J., Gu, W. J., & Zeng, H. (2023) · Cells · doi:10.3390/cells12101428 · Cited by 79
Self-citation
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis
Ming, T., Lei, J., Peng, Y., Wang, M., Liang, Y., Tang, S., Tao, Q., Wang, M., Tang, X., He, Z., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8258 · Cited by 81
Ferroptosis: an important player in the inflammatory response in diabetic nephropathy
Li, J., Li, L., Zhang, Z., Chen, P., Shu, H., Yang, C., Chu, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294317 · Cited by 82
Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors
Cai, H., Ren, Y., Chen, S., Wang, Y., & Chu, L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1119369 · Cited by 79
p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
Liao, Q., Deng, J., Tong, J., Gan, Y., Hong, W., Dong, H., Cao, M., Chen, X., Chen, Y., Xie, B., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.013 · Cited by 80
Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis
Ji, Q., Zeng, F., Zhou, J., Wu, W., Wang, X.-J., Zhang, Z., Zhang, G., Tong, J., Sun, D.-Y., Zhang, J., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01099-5 · Cited by 74
Icariside II induces ferroptosis in renal cell carcinoma cells by regulating the miR-324-3p/GPX4 axis
Yu, R., Zhou, Y., Shi, S., Wang, X. B., Huang, S., & Yu, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154182 · Cited by 72
GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
Kim, J.-W., Min, D. W., Kim, D., Kim, J., Kim, J. M., Lim, H., & Lee, J.-Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-35978-9 · Cited by 72
Multifaceted Roles of Ferroptosis in Lung Diseases
Li, Y., Yang, Y., & Yang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.919187 · Cited by 72
Review: Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer
Zhou, T., Zhang, L., He, J., Miao, Z., Li, Y., Zhang, Y., Liu, Z., Zhang, S.-Z., Chen, Y., Zhou, G.-C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133899 · Cited by 74
Self-citation
Acetylation targeting chimera enables acetylation of the tumor suppressor p53
Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04640 · Cited by 65
Self-citation
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke
Luan, Y., Huang, E., Zhou, R., Huang, J.-J., Yang, Z.-J., Zhou, Z.-P., Zhang, J., Liu, Y., Liu, Z.-F., & Wu, M. T. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0092 · Cited by 66
Self-citation
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors
Punziano, C., Trombetti, S., Cesaro, E., Grosso, M., & Faraonio, R. (2024) · Antioxidants · doi:10.3390/antiox13030298 · Cited by 75
A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients
Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0089 · Cited by 63
Self-citation
ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape
Liu, T., Xu, X., Li, J., Bai, M., Zhu, W., Liu, Y., Liu, S., Zhao, Z., Li, T., Jiang, N., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06333-7 · Cited by 67
Self-citation
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Yang, X. P., Wang, Z., Самович, С. Н., Kapralov, A. A., Amoscato, A. A., Tyurin, V. A., Dar, H. H., Li, Z., Duan, S., Kon, N., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.006 · Cited by 64
Self-citation
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury
Qu, Z., Pang, X., Mei, Z., Li, Y., Zhang, Y., Huang, C., Liu, K., Yu, S., Wang, C., Sun, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103145 · Cited by 62
Self-citation
p53 Promotes Ferroptosis in Macrophages Treated with Fe3O4 Nanoparticles
Wu, C., zhang, B., Shen, Z., Sun, F., Lu, Y., Yuan, L., zhang, G., wang, Z., & Shi, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c00707 · Cited by 65
Targeting mutant p53: a key player in breast cancer pathogenesis and beyond
Qayoom, H., Haq, B. U., Sofi, S., Jan, N., Jan, A., & Mir, M. A. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01863-9 · Cited by 68
Deciphering the acetylation code of p53 in transcription regulation and tumor suppression
Xia, Z., Kon, N., Gu, A. P., Tavana, O., & Gu, W. (2022) · Oncogene · doi:10.1038/s41388-022-02331-9 · Cited by 60
Self-citation
Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells
Lei, M., Zhang, Y., Huang, F., Chen, H., Chen, M., Wu, R.-H., Dai, S.-Z., He, G.-S., Tan, G., & Zheng, W.-P. (2023) · Scientific Reports · doi:10.1038/s41598-023-49136-8 · Cited by 65
Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials
Wang, J., Li, J., Liu, J., Chan, K.-Y., Lee, J. H. S., Lin, K. N., Wang, C. C., & Lau, T. (2024) · Cancers · doi:10.3390/cancers16030512 · Cited by 64
ROS fine-tunes the function and fate of immune cells
Liu, S., Huang, B., Cao, J., Wang, Y., Xiao, H., Zhu, Y., & Zhang, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110069 · Cited by 62
Ferroptosis regulates hemolysis in stored murine and human red blood cells
D’Alessandro, A., Keele, G. R., Hay, A. M., Nemkov, T. G., Earley, E. J., Stephenson, D., Vincent, M. J., Deng, X., Stone, M., Dzieciątkowska, M., et al. (2024) · Blood · doi:10.1182/blood.2024026109 · Cited by 57
Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis
Chen, Y., Zhao, W., Hu, A., Lin, S., Chen, P., Yang, B., Fan, Z., Qi, J., Zhang, W., Gao, H., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05191-x · Cited by 61
Ferroptosis in cardiac hypertrophy and heart failure
Zhang, K., Tian, X.-M., Li, W., & Hao, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115765 · Cited by 55
Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation
Wu, Y., Pi, D., Chen, Y., Zuo, Q., Zhou, S., & Ouyang, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6177553 · Cited by 54
Mesenchymal Stem Cell‐Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO‐1 Signaling Pathway
Liu, J., Huang, J., Zhang, Z., Zhang, R., Sun, Q., Zhang, Z., Liu, Y., & Ma, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3593294 · Cited by 54
Self-citation
p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis
Ye, Z., Xia, Y., Li, L., Li, B., Chen, L., Yu, W., Ruan, Y., Rao, T., Zhou, X., & Fan, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114925 · Cited by 54
Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System
Fujii, J., Osaki, T., Soma, Y., & Matsuda, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098044 · Cited by 56
Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity
Li, Y., Guo, Y., Zhang, K., Zhu, R., Chen, X. S., Zhang, Z., & Yang, W. (2023) · Advanced Science · doi:10.1002/advs.202306580 · Cited by 50
The molecular mechanism of ferroptosis and its role in COPD
Meng, D., Zhu, C., Jia, R., Li, Z., Wang, W., & Song, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1052540 · Cited by 50
Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products
Stepanić, V., & Kučerová-Chlupáčová, M. (2023) · Molecules · doi:10.3390/molecules28020475 · Cited by 54
The mechanisms behind heatstroke-induced intestinal damage
Sun, M., Li, Q., Zou, Z., Liu, J., Gu, Z., & Li, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02210-0 · Cited by 49
Iron Metabolism and Ferroptosis in Peripheral Nerve Injury
Huang, L., Bian, M., Zhang, J., & Jiang, L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5918218 · Cited by 51
Development and validation of cuproptosis-related gene signature in the prognostic prediction of liver cancer
Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.985484 · Cited by 46
Self-citation
Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis
Shi, H., Xiong, L., Yan, G., Du, S., Liu, J., & Shi, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1156062 · Cited by 49
p53 and Zinc: A Malleable Relationship
Ha, J., Prela, O., Carpizo, D. R., & Loh, S. N. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.895887 · Cited by 48
Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression
Zhou, Y., Nakajima, R., Shirasawa, M., Fikriyanti, M., Zhao, L., Iwanaga, R., Bradford, A. P., Kurayoshi, K., Araki, K., & Ohtani, K. (2023) · Biology · doi:10.3390/biology12121511 · Cited by 52
Heavy metals, oxidative stress, and the role of AhR signaling
Kou, Z., Tran, F., & Dai, W. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116769 · Cited by 48
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
Radaelli, E., Assenmacher, C., Verrelle, J., Banerjee, E., Manero, F., Khiati, S., Girona, A., López‐Lluch, G., Navas, P., & Spinazzi, M. (2023) · eLife · doi:10.7554/elife.84710 · Cited by 44
Neuronal ferroptosis after intracerebral hemorrhage
Ren, S., Chen, Y., Wang, L., & Wu, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.966478 · Cited by 43
Mechanisms and inhibitors of ferroptosis in psoriasis
Zhou, Q., Yang, L., Li, T., Wang, K., Huang, X., Shi, J., & Wang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1019447 · Cited by 44
Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model
Liu, P., Chen, W., Kang, Y., Wang, C., Wang, X., Liu, W., Hayashi, T., Qiu, Z., Mizuno, K., Hattori, S., et al. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109691 · Cited by 44
A prospective strategy leveraging nanomedicine for cancer therapy: Pouring ferroptosis on apoptosis
Xia, Y., Zhang, J., & Liu, G. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101740 · Cited by 41
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway
Zou, W., Wang, X., Xia, X., Zhang, T., Nie, M., Xiong, J., & Fang, X. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149338 · Cited by 43
Ferroptosis meets inflammation: A new frontier in cancer therapy
Liu, H., Xue, H., Guo, Q., Xue, X., Yang, L., Zhao, K., & Liu, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217696 · Cited by 44
Self-citation
Lysionotin Induces Ferroptosis to Suppress Development of Colorectal Cancer via Promoting Nrf2 Degradation
Gao, Z., Jiang, J., Hou, L., & Ji, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1366957 · Cited by 40
Melatonin and ferroptosis: Mechanisms and therapeutic implications
Zhang, D., Jia, X., Lin, D., & Ma, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115909 · Cited by 39
Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound
Wang, Z., Wang, J., Fu, Q., Zhao, H., Wang, Z., & Gao, Y. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118030 · Cited by 39
Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation
Yu, M., Li, H., Wang, B., Wu, Z., Wu, Z., Jiang, G., Wang, H., & Huang, Y. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110607 · Cited by 38
SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation
He, G., Zhang, Y., Feng, Y., Chen, T., Liu, M., Zeng, Y., Yin, X., Qu, S., Huang, L., Ke, Y., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18212 · Cited by 37
Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia
Akiyama, H., Carter, B. Z., Andreeff, M., & Ishizawa, J. (2023) · Cells · doi:10.3390/cells12081128 · Cited by 38
Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds
Patanè, G. T., Putaggio, S., Tellone, E., Barreca, D., Ficarra, S., Maffei, C., Calderaro, A., & Laganà, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417279 · Cited by 40
Inhibition of ferroptosis: A new direction in the treatment of ulcerative colitis by traditional Chinese medicine
Guo, M., Du, X., & Wang, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117787 · Cited by 37
Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications
Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 47
p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis
Rius‐Pérez, S. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.07.022 · Cited by 37
Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway
Liao, W., Zhang, R., Chen, G., Zhu, X., Wu, W., Chen, Z., Jiang, C., Lin, Z., Ma, L., & Yu, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116832 · Cited by 39
Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53
Li, H., Wang, B., Wu, S., Dong, S., Jiang, G., Huang, Y., Tong, X., & Yu, M. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110479 · Cited by 35
The role of ferroptosis in metabolic diseases
Xie, L., Fang, B., & Zhang, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119480 · Cited by 35
Ferroptosis induction via targeting metabolic alterations in triple-negative breast cancer
Wang, Y., Sun, Y., Wang, F., Wang, H., & Hu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115866 · Cited by 37
MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis
Di, Y., Zhang, X., Wen, X., Qin, J., Ye, L., Wang, Y., Song, M. L., Wang, Z., & He, W. (2024) · Advanced Science · doi:10.1002/advs.202402795 · Cited by 35
DNA damage repair in megakaryopoiesis: molecular and clinical aspects
Eftekhar, Z., Aghaei, M., & Saki, N. (2024) · Expert Review of Hematology · doi:10.1080/17474086.2024.2391102 · Cited by 35
Multifunctional DNA Tetrahedron for Alzheimer’s Disease Mitochondria-Targeted Therapy by MicroRNA Regulation
Li, W., Peng, X., Mei, X., Dong, M., Li, Y., & Dong, H. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03181 · Cited by 34
Ferroptosis and Pyroptosis in Epilepsy
Feng, F., Luo, R., Mu, D., & Cai, Q. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04018-6 · Cited by 37

Authors: Liu, Y., & Gu, W.
Affiliations: Herbert Irving Comprehensive Cancer Center (US)
Corresponding author: Gu, Wei
ORCID: Liu, Yanqing
Gu, Wei
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2022-01-27
Volume: 29
Issue: 5
Pages: 895-910
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/s41418-022-00943-y
PMC: PMC9091200
OpenAlex: W4210576858
Cited by: 540
References: 141
Citations by year: 2026: 88 · 2025: 153 · 2024: 128 · 2023: 110 · 2022: 60
FWCI: 19.51
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Health & Human Services | NIH | National Cancer Institute (R35CA253059, R01CA254970)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, ferroptosis, tumor suppression, GPX4, iron metabolism, reactive oxygen species, non-apoptotic cell death, cancer therapy
MeSH terms: Ferroptosis, Humans, Neoplasms, Tumor Suppressor Protein p53, Apoptosis, Reactive Oxygen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

p53 in ferroptosis regulation: the new weapon for the old guardian

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks