p53 in ferroptosis regulation: the new weapon for the old guardian

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p53, guardian of the genome

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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Ferroptosis as a p53-mediated activity during tumour suppression

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FSP1 is a glutathione-independent ferroptosis suppressor

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A microRNA component of the p53 tumour suppressor network

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Role of Mitochondria in Ferroptosis

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Glutaminolysis and transferrin regulate ferroptosis

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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The first 30 years of p53: growing ever more complex.

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Putting p53 in context

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

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Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

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Emerging Mechanisms and Disease Relevance of Ferroptosis

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Antioxidant responses and cellular adjustments to oxidative stress

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Cytoplasmic functions of the tumour suppressor p53

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P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

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The development of the concept of ferroptosis

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

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ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

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p53: 800 million years of evolution and 40 years of discovery

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

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Acetylation Is Indispensable for p53 Activation

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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

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Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

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Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

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Limiting the impact of light pollution on human health, environment and stellar visibility

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The Hallmarks of Ferroptosis

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p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

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Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

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Characteristics and Biomarkers of Ferroptosis

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

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Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

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MEKK1/JNK signaling stabilizes and activates p53

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Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

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Hallmarks of Health

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A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

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Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

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Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

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p53 modifications: exquisite decorations of the powerful guardian

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PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelPreprint

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Targeting p53 for the treatment of cancer

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iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

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p53 and Tumor Suppression: It Takes a Network

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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

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Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

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p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

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ESCRT-III–dependent membrane repair blocks ferroptosis

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Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

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LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53

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MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodelingPreprint

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The complexity of p53-mediated metabolic regulation in tumor suppression

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Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis

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Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

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Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation

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Deconstructing networks of p53-mediated tumor suppression in vivo

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Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

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Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

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A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

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p53‐mediated induction of Cox‐2 counteracts p53‐ or genotoxic stress‐induced apoptosis

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Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

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Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis

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Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

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Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

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Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

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The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

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p53-dependent Induction of PVT1 and miR-1204

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Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats

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APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

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Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

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Current developments of targeting the p53 signaling pathway for cancer treatment

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p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

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Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2Preprint

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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells

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P53‐dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride‐induced liver fibrosis and hepatic stellate cell activation

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Role of p53 in Neurodegenerative Diseases

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The most popular genes in the human genome

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Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

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Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis

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Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

Huang, C., Yang, M., Deng, J., Li, P., Su, W., & Jiang, R. (2018) · Oncology Reports · doi:10.3892/or.2018.6585 · Cited by 106

Suppression of Host p53 Is Critical for Plasmodium Liver-Stage Infection

Kaushansky, A., Ye, A. S., Austin, L. S., Mikolajczak, S. A., Vaughan, A. M., Camargo, N. M., Metzger, P. G., Douglass, A. N., MacBeath, G., & Kappe, S. H. I. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.010 · Cited by 105

Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1

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SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

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Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

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p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides

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Cytoglobin promotes sensitivity to ferroptosis by regulating p53‐YAP1 axis in colon cancer cells

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Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

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miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities

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Chapter 5 Sirtuins and p53

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Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

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Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis

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Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F

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Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

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Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway

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CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia

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Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

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Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

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Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis

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A-Lipoic Acid Alleviates Folic Acid-Induced Renal Damage Through Inhibition of Ferroptosis

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p21 can be a barrier to ferroptosis independent of p53

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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppressionPreprint

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A functionally significant SNP in TP53 and breast cancer risk in African-American women

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Regulation of ferroptosis by non‑coding RNAs in the development and treatment of cancer (Review)

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Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation

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Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53

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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

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Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

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Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

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Time Course of Changes in Sorafenib‐Treated Hepatocellular Carcinoma Cells Suggests Involvement of Phospho‐Regulated Signaling in Ferroptosis Induction

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SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury

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p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells

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MicroRNA-34c acts as a bidirectional switch in the maturation of insulin-producing cells derived from mesenchymal stem cells

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Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

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Biphasic Effects of Blue Light Irradiation on Human Umbilical Vein Endothelial Cells

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Targeting p53 pathways: mechanisms, structures, and advances in therapy

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The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions

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GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

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Understanding the complexity of p53 in a new era of tumor suppression

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Mutant p53 in cancer: from molecular mechanism to therapeutic modulation

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Ferroptosis and the bidirectional regulatory factor p53

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p53 and Ferroptosis

Jiang, S., & Xie, Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_7

The tumor suppressor protein p53 and the ferroptosis network

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p53: A double-edged sword in tumor ferroptosis

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