The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
N6-methyladenosine links RNA metabolism to cancer progression
Open accessAbstract
N6-methyladenosine (m6A) is the most abundant mRNA modification. With the development of antibody-based sequencing technologies and the findings of m6A-related “writers”, “erasers”, and “readers”, the relationships between m6A and mRNA metabolism are emerging. The m6A modification influences almost every step of RNA metabolism that comprises mRNA processing, mRNA exporting from nucleus to cytoplasm, mRNA translation, mRNA decay, and the biogenesis of long-non-coding RNA (lncRNA) and microRNA (miRNA). Recently, more and more studies have found m6A is associated with cancer, contributing to the self-renewal of cancer stem cell, promotion of cancer cell proliferation, and resistance to radiotherapy or chemotherapy. Inhibitors of m6A-related factors have been explored, and some of them were identified to inhibit cancer progression, indicating that m6A could be a target for cancer therapy. In this review, we are trying to summarize the regulation and function of m6A in human carcinogenesis.
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Cites
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Cited by
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
The potential role of RNA N6-methyladenosine in Cancer progression
Wang, T., Kong, S., Tao, M., & Ju, S. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01204-7 · Cited by 1,013
The role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 963
The interplay between m6A RNA methylation and noncoding RNA in cancer
Ma, S., Chen, C., Ji, X., Liu, J., Zhou, Q., Wang, G., Yuan, W., Kan, Q., & Sun, Z. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0805-7 · Cited by 632
Accurate detection of m6A RNA modifications in native RNA sequences
Liu, H., Begik, O., Lucas, M. C., Ramirez, J. M., Mason, C. E., Wiener, D., Schwartz, S., Mattick, J. S., Smith, M. A., & Novoa, E. M. (2019) · Nature Communications · doi:10.1038/s41467-019-11713-9 · Cited by 518
Metadata
- Authors
- Dai, D., Wang, H., Zhu, L., Jin, H., & Wang, X.
- Venue
- Cell Death & Disease
- Published
- 2018-01-26
- Volume
- 9
- Issue
- 2
- Pages
- 124-124
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2791159414
- Cited by
- 473
- References
- 103
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- gold
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