Probiotics’ effect on visceral and subcutaneous adipose tissue: A systematic review of randomized controlled trials
Abstract
Probiotics are shown to alter the microbiota, leading to a favorable environment, in which weight loss and metabolic parameters are improve. However, the results on probiotics' effect on specific types of central adipose tissues, mainly visceral (VAT) and subcutaneous adipose tissue (SAT), are conflicting. Therefore, we conducted a systematic review, aimed to evaluate the effects of probiotics on VAT and SAT. PubMed, SCOPUS, EBSCO, and LILACS databases were searched for studies that investigated the effect of probiotics on VAT and SAT. Fixed effects were used to calculate the pooled difference in means (DM) and 95% confidence intervals (95%CI). Fourteen publications met the inclusion criteria, which consisted of 1523 participants. For VAT, overall, there was a significant decrease (DM = -3.63 cm 2, 95% CI: -5.08 to -2.17, p < 0.001). When stratified by type of probiotic, single Bifidobacterium (DM = -4.49 cm 2, 95% CI:-7.37 to -1.61, p = 0.002) and single Lactobacillus probiotics (DM = -3.84 cm 2, 95% CI:-5.74 to -1.93, p < 0.001) resulted in significant reductions. Mixed probiotics had no effect. For SAT, overall, there was a significant decrease (DM = -2.91 cm 2, 95% CI:-4.82 to -1.01, p = 0.003), and when stratified by type of probiotic, single Lactobacillus (DM = -3.39 cm 2, 95% CI:-5.90 to -0.88, p = 0.008) and mixed probiotics (DM = -5.97 cm 2, 95% CI:-10.32 to -1.62, p = 0.007) resulted in a significant decrease. Single Bifidobacterium probiotics had no effect. Using meta-regression, no association was observed between the total daily probiotic dose and VAT or SAT reduction. This study shows that probiotics have a beneficial effect on central adiposity. Single Lactobacillus-based probiotics reduced VAT and SAT, whereas Bifidobacterium-based probiotics reduce VAT.
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Vazquez-Marroquin, G., Ochoa-Précoma, R., Porchia, L. M., Pérez-Fuentes, R., Nicolás‐Toledo, L., Rodríguez‐Antolín, J., & González-Mejía, M. E. (2023) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2023.01.006 · Cited by 6 · see citing works
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Pontes‐Silva, A., Ковалева, О. Н., Gadzhiakhmedova, A. N., Luchina, A. M., Sinelnikov, M. Y., Maslennikov, R. V., Musaeva, A. M., Zharova, N. V., Zharikova, T. M., & Zharikov, Y. O. (2023) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.20230721 · Cited by 1 · see citing works
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Microbiome and Diseases: Metabolic Disorders
Clavel, T., & Ecker, J. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_16
- Authors
- Porchia, L. M., Vazquez-Marroquin, G., Ochoa-Précoma, R., Pérez-Fuentes, R., & Gonzalez-Mejia, M. E.
- Affiliations
- Mexican Social Security Institute (MX)
- Universidad Autónoma de Tlaxcala (MX)
- Benemérita Universidad Autónoma de Puebla (MX)
- Venue
- European Journal of Clinical Nutrition
- Published
- 2022-04-13
- Volume
- 76
- Issue
- 12
- Pages
- 1646-1656
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W4223419578
- Cited by
- 10
- References
- 94
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Programa para el Desarrollo Profesional Docente (CA-160 FACMED) Vicerrectorıa de Investigacion, Benemerita Universidad Autonoma de Puebla, Mexico (GOMM-SAL21-G).
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, Bifidobacterium, subcutaneous adipose tissue, visceral adipose tissue, abdominal obesity, gut microbiota, weight loss, probiotic dosage, Lactobacillus
- MeSH terms
- Adipose Tissue, Humans, Randomized Controlled Trials as Topic, Probiotics, Subcutaneous Fat, Intra-Abdominal Fat
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