The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
Open accessAbstract
Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a putative RNA:DNA helicase involved in transcription and in the maintenance of genome integrity. Here, using ChIP followed by high throughput sequencing (ChIP-seq), we report that senataxin is recruited at DNA double-strand breaks (DSBs) when they occur in transcriptionally active loci. Genome-wide mapping unveiled that RNA:DNA hybrids accumulate on DSB-flanking chromatin but display a narrow, DSB-induced, depletion near DNA ends coinciding with senataxin binding. Although neither required for resection nor for timely repair of DSBs, senataxin was found to promote Rad51 recruitment, to minimize illegitimate rejoining of distant DNA ends and to sustain cell viability following DSB production in active genes. Our data suggest that senataxin functions at DSBs in order to limit translocations and ensure cell viability, providing new insights on AOA2/ALS4 neuropathies.
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Cites
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
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Self-citationAcetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
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Self-citationGenetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences
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Genome Organization Drives Chromosome Fragility
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Self-citation
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Clouaire, T., Rocher, V., Lashgari, A., Arnould, C., Aguirrebengoa, M., Biernacka, A., Skrzypczak, M., Aymard, F., Fongang, B., Dojer, N., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.020 · Cited by 298
Self-citationRegulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
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Metadata
- Authors
- Cohen, S., Puget, N., Lin, Y.-L., Clouaire, T., Aguirrebengoa, M., Rocher, V., Pasero, P., Canitrot, Y., & Legube, G.
- Venue
- Nature Communications
- Published
- 2018-02-07
- Volume
- 9
- Issue
- 1
- Pages
- 533-533
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2798187866
- Cited by
- 337
- References
- 12
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cohen, S., Puget, N., Lin, Y.-L., Clouaire, T., Aguirrebengoa, M., Rocher, V., Pasero, P., Canitrot, Y., & Legube, G. (2018). Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations. Nature Communications. https://doi.org/10.1038/s41467-018-02894-w
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