Specialized metabolites from the microbiome in health and disease

Sharon, Gil; Garg, Neha; Debelius, Justine; Knight, Rob; Dorrestein, Pieter C.; Mazmanian, Sarkis K.

doi:10.1016/j.cmet.2014.10.016

Cited by 560Gut microbiota and healthOral microbiology and periodontitis researchMetabolomics and Mass Spectrometry Studies

Specialized metabolites from the microbiome in health and disease

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Sharon, Gil, Garg, Neha, Debelius, Justine, Knight, Rob, Dorrestein, Pieter C., Mazmanian, Sarkis K.·2014·Cell Metabolism

DOI 10.1016/j.cmet.2014.10.016PMC PMC4337795

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Abstract

The microbiota, and the genes that comprise its microbiome, play key roles in human health. Host-microbe interactions affect immunity, metabolism, development, and behavior, and dysbiosis of gut bacteria contributes to disease. Despite advances in correlating changes in the microbiota with various conditions, specific mechanisms of host-microbiota signaling remain largely elusive. We discuss the synthesis of microbial metabolites, their absorption, and potential physiological effects on the host. We propose that the effects of specialized metabolites may explain present knowledge gaps in linking the gut microbiota to biological host mechanisms during initial colonization, and in health and disease.

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The gut microbiome affects atherogenesis through its degradation of phosphatidylcholine.
“Beyond these general mechanisms, the gut microbiome affects atherogenesis more specifically through its degradation of phosphatidylcholine, which is abundant in eggs, cheese, seafood and red meat (Jonsson and Bäckhed, 2017; Sharon et al., 2014; Sonnenburg and Bäckhed, 2016).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
The microbiome is implicated in atherosclerosis.
“The primary cause of cardiovascular disease is atherosclerosis, a process in which the microbiome has been implicated as well (Jonsson and Bäckhed, 2017; Sharon et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
The gut microbiota appears to influence nearly every aspect of host physiology, including energy balance, cardiovascular health, chronic inflammation, and development of adaptive immune cells.
“the gut microbiota appears to influence nearly every aspect of host physiology, including energy balance, cardiovascular health, chronic inflammation, development of adaptive immune cells and many more systems that fall outside of the scope of this review (Rooks and Garrett, 2016; Sharon et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
Changes in the microbiome often result in altered metabolic profiles, impacting the availability and diversity of nutrients and microbial metabolites.
“changes in the microbiome often result in altered metabolic profiles, impacting the availability and diversity of nutrients and microbial metabolites (Dodd et al., 2017; Melnik et al., 2017; Sharon et al., 2014; Wikoff et al., 2009).”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Sharon et al., 2014

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Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut
Rivière, A., Selak, M., Lantin, D., Leroy, F., & Vuyst, L. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00979 · Cited by 1,746 · see citing works
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606 · see citing works
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works
Self-citation
Chemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080 · see citing works
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
Self-citation
Microbes, Metabolites, and the Gut-Lung Axis
Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028 · see citing works
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“…gut microbiota appears to influence nearly every aspect of host physiology, including energy balance, cardiovascular health, chronic inflammation, development of adaptive immune cells, andmany more systems that fall outside of the scope of this review (Rooks and Garrett, 2016; Sharon et al., 2014).”
BackgroundInfluential
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works
Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750 · see citing works
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 742 · see citing works
Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
GPCR-Mediated Signaling of Metabolites
Husted, A. S., Trauelsen, M., Rudenko, O., Hjorth, S. A., & Schwartz, T. W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.008 · Cited by 586 · see citing works
Deciphering microbial interactions in synthetic human gut microbiome communities
Venturelli, O. S., Carr, A. V., Fisher, G., Hsu, R. H., Lau, R., Bowen, B. P., Hromada, S. E., Northen, T. R., & Arkin, A. P. (2018) · Molecular Systems Biology · doi:10.15252/msb.20178157 · Cited by 539 · see citing works
The role of the microbiome in NAFLD and NASH
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A gut-derived metabolite alters brain activity and anxiety behaviour in mice
Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature · doi:10.1038/s41586-022-04396-8 · Cited by 489 · see citing works
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Metagenomics, Metatranscriptomics, and Metabolomics Approaches for Microbiome Analysis
Aguiar‐Pulido, V., Huang, W., Suárez-Ulloa, V., Cickovski, T., Mathee, K., & Narasimhan, G. (2016) · Evolutionary Bioinformatics · doi:10.4137/ebo.s36436 · Cited by 514 · see citing works
Advances in pathogenesis and therapeutic strategies for osteoporosis
Song, S., Guo, Y., Yang, Y., & Fu, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108168 · Cited by 476 · see citing works
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
Serena, C., Ceperuelo‐Mallafré, V., Keiran, N., Queipo‐Ortuño, M. I., Bernal, R., Gómez-Huelgas, R., Urpí-Sardà, M., Sabater, M., Pérez‐Brocal, V., Andrés‐Lacueva, C., et al. (2018) · The ISME Journal · doi:10.1038/s41396-018-0068-2 · Cited by 411 · see citing works
Diet, Microbiota and Gut-Lung Connection
Anand, S., & Mande, S. S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02147 · Cited by 409 · see citing works
SpaceM reveals metabolic states of single cells
Rappez, L., Stadler, M., Triana, S., Gathungu, R., Ovchinnikova, K., Phapale, P., Heikenwalder, M., & Alexandrov, T. (2021) · Nature Methods · doi:10.1038/s41592-021-01198-0 · Cited by 320 · see citing works
Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms
Wallen, Z. D., Demirkan, A., Twa, G., Cohen, G., Dean, M. N., Standaert, D. G., Sampson, T. R., & Payami, H. (2022) · Nature Communications · doi:10.1038/s41467-022-34667-x · Cited by 346 · see citing works
Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
Pessione, E., & Cirrincione, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00876 · Cited by 333 · see citing works
Microbiome therapeutics — Advances and challenges
Mimee, M., Citorik, R. J., & Lu, T. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.032 · Cited by 317 · see citing works
Commensal bacteria and essential amino acids control food choice behavior and reproduction
Leitão-Gonçalves, R., Carvalho-Santos, Z., Francisco, A. P., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D. W., & Ribeiro, C. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000862 · Cited by 315 · see citing works
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
Kindt, A., Liebisch, G., Clavel, T., Haller, D., Hörmannsperger, G., Yoon, H., Kolmeder, D., Sigruener, A., Krautbauer, S., Seeliger, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05767-4 · Cited by 311 · see citing works
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 285 · see citing works
Spatial Metabolomics and Imaging Mass Spectrometry in the Age of Artificial Intelligence
Alexandrov, T. (2020) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-011420-031537 · Cited by 286 · see citing works
Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma
Chen, F., Dai, X., Zhou, C., Li, K.-X., Zhang, Y., Lou, X., Zhu, Y., Sun, Y., Peng, B.-X., & Cui, W. (2021) · Gut · doi:10.1136/gutjnl-2020-323476 · Cited by 286 · see citing works
Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences
Mallick, H., Franzosa, E. A., Mclver, L. J., Banerjee, S., Sirota‐Madi, A., Kostic, A. D., Clish, C. B., Vlamakis, H. C., Xavier, R. J., & Huttenhower, C. (2019) · Nature Communications · doi:10.1038/s41467-019-10927-1 · Cited by 279 · see citing works
Association of Psoriasis With Inflammatory Bowel Disease
Fu, Y., Lee, C., & Chi, C. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.3631 · Cited by 286 · see citing works
Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats
Jaglin, M., Rhimi, M., Philippe, C., Pons, N., Bruneau, A., Goustard, B., Daugé, V., Maguin, E., Naudon, L., & Rabot, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00216 · Cited by 269 · see citing works
Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer
Bultman, S. J. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500902 · Cited by 269 · see citing works
Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market
Diez-Gutiérrez, L., Vicente, L. S., Barrón, L. J. R., Villarán, M. C., & Chávarri, M. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103669 · Cited by 256 · see citing works
Metabolic regulation of macrophage phenotype and function
Saha, S., Shalova, I. N., & Biswas, S. K. (2017) · Immunological Reviews · doi:10.1111/imr.12603 · Cited by 252 · see citing works
Microbiome: Focus on Causation and Mechanism
Fischbach, M. A. (2018) · Cell · doi:10.1016/j.cell.2018.07.038 · Cited by 251 · see citing works
The colibactin warhead crosslinks DNA
Vizcaino, M. I., & Crawford, J. M. (2015) · Nature Chemistry · doi:10.1038/nchem.2221 · Cited by 247 · see citing works
The Microbiome–Estrogen Connection and Breast Cancer Risk
Parida, S., & Sharma, D. (2019) · Cells · doi:10.3390/cells8121642 · Cited by 248 · see citing works
Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress
Bharwani, A., Mian, M. F., Surette, M. G., Bienenstock, J., & Forsythe, P. (2017) · BMC Medicine · doi:10.1186/s12916-016-0771-7 · Cited by 236 · see citing works
Schistosoma “Eggs-Iting” the Host: Granuloma Formation and Egg Excretion
Schwartz, C., & Fallon, P. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02492 · Cited by 236 · see citing works
The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions
Ellis, S. R., Nguyen, M., Vaughn, A. R., Notay, M., Burney, W. A., Sandhu, S., & Sivamani, R. K. (2019) · Microorganisms · doi:10.3390/microorganisms7110550 · Cited by 236 · see citing works
Gut Microbiota Metabolism and Interaction with Food Components
Vernocchi, P., CHIERICO, F. D., & Putignani, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103688 · Cited by 236 · see citing works
Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis
Braga, J. D., Thongngam, M., & Kumrungsee, T. (2024) · npj Science of Food · doi:10.1038/s41538-024-00253-2 · Cited by 229 · see citing works
Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria
Martínez-del Campo, A., Bodea, S., Hamer, H. A., Marks, J. A., Haiser, H. J., Turnbaugh, P. J., & Balskus, E. P. (2015) · mBio · doi:10.1128/mbio.00042-15 · Cited by 224 · see citing works
Mutual Cross-Feeding Interactions between Bifidobacterium longum subsp. longum NCC2705 and Eubacterium rectale ATCC 33656 Explain the Bifidogenic and Butyrogenic Effects of Arabinoxylan Oligosaccharides
Rivière, A., Gagnon, M., Weckx, S., Roy, D., & Vuyst, L. D. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02089-15 · Cited by 219 · see citing works
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity
Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Picu, A. A., Petcu, L. M., Cucu, N., & Chifiriuc, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00021 · Cited by 207 · see citing works
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes
Baumann-Dudenhoeffer, A. M., D’Souza, A. W., Tarr, P. I., Warner, B. B., & Dantas, G. A. (2018) · Nature Medicine · doi:10.1038/s41591-018-0216-2 · Cited by 203 · see citing works
Gut microbiota and colorectal cancer
Gao, R., Gao, Z., Huang, L., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2881-8 · Cited by 205 · see citing works
Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome
Kato, T., Yamazaki, K., Nakajima, M., Date, Y., Kikuchi, J., Hase, K., Ohno, H., & Yamazaki, K. (2018) · mSphere · doi:10.1128/msphere.00460-18 · Cited by 199 · see citing works
Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
Clos‐Garcia, M., Andrés, N., Fernández‐Eulate, G., Abecia, L., Lavín, J. L., Liempd, S. M. V., Cabrera, D., Royo, F., Valero, A., Errazquin, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.031 · Cited by 198 · see citing works
The Cellular and Molecular Basis of Translational Immunometabolism
Norata, G. D., Caligiuri, G., Chavakis, T., Matarese, G., Netea, M. G., Nicoletti, A., O'Neill, L. A. J., & Marelli‐Berg, F. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.023 · Cited by 193 · see citing works
Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism
Miro-Blanch, J., & Yanes, O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00638 · Cited by 195 · see citing works
Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression
Gonzalez, A., Krieg, R. J., Massey, H. D., Carl, D. E., Ghosh, S., Gehr, T. W. B., & Ghosh, S. S. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy238 · Cited by 193 · see citing works
Integrative Physiology of Fasting
Secor, S. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150013 · Cited by 183 · see citing works
Gut microbiota composition and bone mineral loss—epidemiologic evidence from individuals in Wuhan, China
Li, C., Huang, Q., Yang, R., Dai, Y., Zeng, Y., Tao, L., Li, X., Zeng, J., & Wang, Q. (2019) · Osteoporosis International · doi:10.1007/s00198-019-04855-5 · Cited by 184 · see citing works
Gut microbiota-derived metabolites in obesity: a systematic review
Ejtahed, H., Angoorani, P., Soroush, A., Hasani‐Ranjbar, S., Siadat, S. D., & Larijani, B. A. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2019-026 · Cited by 187 · see citing works
Role of gut microbiota in identification of novel TCM-derived active metabolites
Lin, T., Lu, C., Lai, W.-F., Wu, T., Lu, J., Chen, Y.-M., Tzeng, C., Liu, H., Wei, H., & Lai, H. (2020) · Protein & Cell · doi:10.1007/s13238-020-00784-w · Cited by 175 · see citing works
Bacterial Signaling to the Nervous System through Toxins and Metabolites
Yang, N. J., & Chiu, I. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.12.023 · Cited by 165 · see citing works
Gut microbiota: a potential regulator of neurodevelopment
Tognini, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00025 · Cited by 163 · see citing works
Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions
Shi, Y., & Bode, H. B. (2018) · Natural Product Reports · doi:10.1039/c7np00054e · Cited by 162 · see citing works
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity
Nyangahu, D. D., Lennard, K. S., Brown, B. P., Darby, M., Wendoh, J. M., Havyarimana, E., Smith, P., Butcher, J., Stintzi, A. P., Mulder, N., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0511-7 · Cited by 161 · see citing works
Gut microbiota directs PPARγ‐driven reprogramming of the liver circadian clock by nutritional challenge
Murakami, M., Tognini, P., Liu, Y., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2016) · EMBO Reports · doi:10.15252/embr.201642463 · Cited by 155 · see citing works
Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells
Nastasi, C., Fredholm, S., Willerslev-Olsen, A., Hansen, M., Bonefeld, C. M., Geisler, C., Andersen, M. H., Ødum, N., & Woetmann, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-15099-w · Cited by 160 · see citing works
Administration of Non-Absorbable Antibiotics to Pregnant Mice to Perturb the Maternal Gut Microbiota Is Associated with Alterations in Offspring Behavior
Tochitani, S., Ikeno, T., Ito, T., Sakurai, A., Yamauchi, T., & Matsuzaki, H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0138293 · Cited by 157 · see citing works
Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?
Nettleton, J. E., Reimer, R. A., & Shearer, J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.029 · Cited by 155 · see citing works
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Covington, B. C., MCLEAN, J. A. J., & Bachmann, B. O. (2016) · Natural Product Reports · doi:10.1039/c6np00048g · Cited by 150 · see citing works
Accessing Bioactive Natural Products from the Human Microbiome
Milshteyn, A., Colosimo, D. A., & Brady, S. F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.013 · Cited by 147 · see citing works
Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth
Grier, A., Qiu, X., Bandyopadhyay, S., Holden‐Wiltse, J., Kessler, H. A., Gill, A. L., Hamilton, B., Huyck, H. L., Misra, S. K., Mariani, T. J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0377-0 · Cited by 149 · see citing works
Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour
Henriques, S. F., Dhakan, D. B., Serra, L., Francisco, A. P., Carvalho-Santos, Z., Baltazar, C., Elias, A. P., Anjos, M., Zhang, T., Maddocks, O. D. K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18049-9 · Cited by 146 · see citing works
Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases
Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 151 · see citing works
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome
Frye, R. E., Rose, S., Slattery, J. M., & MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.27458 · Cited by 142 · see citing works
The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions
Abdollahi‐Roodsaz, S., Abramson, S. B., & Scher, J. U. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.68 · Cited by 141 · see citing works
Exploring and Understanding the Biochemical Diversity of the Human Microbiota
Koppel, N., & Balskus, E. P. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.12.008 · Cited by 138 · see citing works
Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
Montagner, A., Korecka, A., Polizzi, A., Lippi, Y., Blum, Y., Canlet, C., Tremblay-Franco, M., Gautier-Stein, A., Burcelin, R., Yen, Y.-C., et al. (2016) · Scientific Reports · doi:10.1038/srep20127 · Cited by 137 · see citing works
“Because the gut microbiome actively participates in gaining energy from food and in producing diet-derived products, the question of its impact on peripheral clock functions in metabolic organs is important 26 .”
Symbiosis-inspired approaches to antibiotic discovery
Adnani, N., Rajski, S. R., & Bugni, T. S. (2017) · Natural Product Reports · doi:10.1039/c7np00009j · Cited by 135 · see citing works
Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases
Tu, P., Chi, L., Bodnar, W. M., Zhang, Z., Gao, B., Bian, X., Stewart, J. R., Fry, R. C., & Lü, K. (2020) · Toxics · doi:10.3390/toxics8010019 · Cited by 130 · see citing works
Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense
Luan, H. H., & Medzhitov, R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.013 · Cited by 130 · see citing works
“For example, two of the best-characterized microbial metabolism pathways influencing the immune system are short-chain fatty acid production and tryptophan metabolism (Sharon et al., 2014).”
Background
Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127 · see citing works
Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model
Hoffman, J. D., Yanckello, L. M., Chlipala, G. E., Hammond, T. C., McCulloch, S. D., Parikh, I. J., Sun, S., Morganti, J. M., Green, S. J., & Lin, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221828 · Cited by 128 · see citing works
Current explorations of nutrition and the gut microbiome: a comprehensive evaluation of the review literature
Frame, L. A., Costa, E., & Jackson, S. A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz106 · Cited by 127 · see citing works
Let thy food be thy medicine….when possible
Witkamp, R. F., & van Norren, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.026 · Cited by 130 · see citing works
Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 127 · see citing works
Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress
Xie, R., Jiang, P., Li, L., Jiang, J. H., Yu, B., Rao, J., Liu, H., Wei, W., & Qiao, Y. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.12.013 · Cited by 126 · see citing works
Nutritional Correlates of Human Oral Microbiome
Kato, I., Vasquez, A. A., Moyerbrailean, G. A., Land, S. J., Djurić, Z., Sun, J., Lin, H.-S., & Ram, J. L. (2016) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1185386 · Cited by 129 · see citing works
High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group
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Authors: Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K.
Affiliations: California Institute of Technology (US)
University of California San Diego (US)
University of Colorado Boulder (US)
Howard Hughes Medical Institute (US)
Corresponding author: Mazmanian, Sarkis K.
ORCID: Sharon, Gil
Garg, Neha
Debelius, Justine
Knight, Rob
Dorrestein, Pieter C.
Mazmanian, Sarkis K.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2014-11
Volume: 20
Issue: 5
Pages: 719-730
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2014.10.016
PMC: PMC4337795
OpenAlex: W2092725930
Cited by: 544
References: 155
Citations by year: 2026: 18 · 2025: 33 · 2024: 46 · 2023: 48 · 2022: 59 · 2021: 62 · 2020: 66 · 2019: 46 · 2018: 59 · 2017: 42 · 2016: 36 · 2015: 27
FWCI: 14.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (UL1TR000100)
National Institute of Mental Health (R01MH100556, MH100556)
National Institute of General Medical Sciences (GM099535, R01GM099535, GM095384, R01GM095384)
National Institute of Allergy and Infectious Diseases (R01AI095125, AI095125)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 078938, R01DK078938, R56DK078938)
National Institute of Neurological Disorders and Stroke (R01NS085910)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: gut microbiota, microbial metabolites, secondary metabolites, host-microbe interactions, dysbiosis, host-microbe signaling, host immunity, host metabolism, microbial colonization, disease
MeSH terms: Bacteria, Cardiovascular Diseases, Cystic Fibrosis, Health, Humans, Neoplasms, Gastrointestinal Tract, Metagenome, Microbiota

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