Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
Open accessAbstract
Roux-en-Y gastric bypass (RYGB) results in rapid weight loss, reduced adiposity, and improved glucose metabolism. These effects are not simply attributable to decreased caloric intake or absorption, but the mechanisms linking rearrangement of the gastrointestinal tract to these metabolic outcomes are largely unknown. Studies in humans and rats have shown that RYGB restructures the gut microbiota, prompting the hypothesis that some of the effects of RYGB are caused by altered host-microbial interactions. To test this hypothesis, we used a mouse model of RYGB that recapitulates many of the metabolic outcomes in humans. 16S ribosomal RNA gene sequencing of murine fecal samples collected after RYGB surgery, sham surgery, or sham surgery coupled to caloric restriction revealed that alterations to the gut microbiota after RYGB are conserved among humans, rats, and mice, resulting in a rapid and sustained increase in the relative abundance of Gammaproteobacteria (Escherichia) and Verrucomicrobia (Akkermansia). These changes were independent of weight change and caloric restriction, were detectable throughout the length of the gastrointestinal tract, and were most evident in the distal gut, downstream of the surgical manipulation site. Transfer of the gut microbiota from RYGB-treated mice to nonoperated, germ-free mice resulted in weight loss and decreased fat mass in the recipient animals relative to recipients of microbiota induced by sham surgery, potentially due to altered microbial production of short-chain fatty acids. These findings provide the first empirical support for the claim that changes in the gut microbiota contribute to reduced host weight and adiposity after RYGB surgery.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Changes in the composition and diversity of the gut microbiota have been observed after vertical sleeve gastrectomy and RYGB in mice.
“Recent work has also indicated that the gut microbiota may mediate some of the beneficial effects of bariatric surgery, and changes in the composition and diversity of the gut microbiota have been observed in the short term after RYGB in humans (Furet et al., 2010; Graessler et al., 2013; Kong et al., 2013; Zhang et al., 2009), as well as after vertical sleeve gastrectomy and RYGB in mice (Liou et”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Liou et al., 2013
The results are consistent with a mouse study showing a reduced ability of the RYGB microbiota to promote adiposity.
“These results are also consistent with a mouse study showing a reduced ability of the RYGB microbiota to promote adiposity (Liou et al., 2013).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Liou et al., 2013
Early-life antibiotic treatment predisposes animal models to obesity.
“Antibiotic treatment in early life predisposes to obesity in animal models81”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [81]
Multiple evidence streams indicate that gut microbes contribute to obesity.
“Several lines of evidence support the role of gut microbiota in obesity.”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Self-citationMetagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Self-citationGlobal patterns of 16S rRNA diversity at a depth of millions of sequences per sample
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Lozupone, C., Turnbaugh, P. J., Fierer, N., & Knight, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000080107 · Cited by 9,633 · see citing works
Self-citationUltra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Self-citationThe gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Self-citationDe Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works
Self-citationThe Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Self-citationTurnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Self-citationEnergy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106 · see citing works
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985 · see citing works
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970 · see citing works
Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012) · Gut Microbes · doi:10.4161/gmic.19625 · Cited by 864 · see citing works
Greenblum, S., Turnbaugh, P. J., & Borenstein, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116053109 · Cited by 821 · see citing works
Self-citationThe role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786 · see citing works
Microbes inside—from diversity to function: the case of Akkermansia
Belzer, C., & de Vos, W. M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.6 · Cited by 715 · see citing works
Rubino, F., Gagner, M., Gentileschi, P., Kini, S. U., Fukuyama, S., Feng, J. J., & Diamond, E. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133117.12646.48 · Cited by 638 · see citing works
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 582 · see citing works
Hansen, C. H. F., Krych, Ł., Nielsen, D. S., Vogensen, F. K., Hansen, L. H., Sørensen, S. J., Buschard, K., & Hansen, A. K. (2012) · Diabetologia · doi:10.1007/s00125-012-2564-7 · Cited by 496 · see citing works
Collins, S., Martin, T. L., Surwit, R. S., & Robidoux, J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.006 · Cited by 486 · see citing works
Hales, B. A., Edwards, C., Ritchie, D. A., et al. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.2.668-675.1996 · Cited by 484 · see citing works
Metabolic surgery profoundly influences gut microbial–host metabolic cross-talk
Li, J. V., Ashrafian, H., Bueter, M., Kinross, J. K., Sands, C. J., le Roux, C. W., Bloom, S. R., Darzi, A. W., Athanasiou, T., Marchesi, J. R., et al. (2011) · Gut · doi:10.1136/gut.2010.234708 · Cited by 444 · see citing works
Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery
Thaler, J. P., & Cummings, D. E. (2009) · Endocrinology · doi:10.1210/en.2009-0367 · Cited by 443 · see citing works
Responses of gut microbiota to diet composition and weight loss in lean and obese mice
Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity · doi:10.1038/oby.2011.111 · Cited by 406 · see citing works
Metabolic Surgery to Treat Type 2 Diabetes: Clinical Outcomes and Mechanisms of Action
Rubino, F., Schauer, P. R., Kaplan, L. M., & Cummings, D. E. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.051308.105148 · Cited by 383 · see citing works
Self-citationShort chain fatty acids and their receptors: new metabolic targets
Layden, B. T., Angueira, A. R., Brodsky, M. R., Durai, V., & Lowe, W. L. (2012) · Translational research · doi:10.1016/j.trsl.2012.10.007 · Cited by 357 · see citing works
Interaction between colonic acetate and propionate in humans
Wolever, T. M. S., Spadafora, P., & Eshuis, H. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.3.681 · Cited by 333 · see citing works
Hansen, E. E., Lozupone, C., Rey, F. E., Wu, M., Guruge, J. L., Narra, A., Goodfellow, J., Zaneveld, J., McDonald, D. T., Goodrich, J. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000071108 · Cited by 226 · see citing works
Gastric Bypass Increases Energy Expenditure in Rats
Bueter, M., Löwenstein, C., Olbers, T., Wang, M., Cluny, N. L., Bloom, S. R., Sharkey, K. A., Lutz, T. A., & le Roux, C. W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.012 · Cited by 206 · see citing works
Scanlan, P. D., Shanahan, F., & Marchesi, J. R. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-79 · Cited by 206 · see citing works
Roux‐en‐Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet‐induced Obese Rats
Stylopoulos, N., Hoppin, A. G., & Kaplan, L. M. (2009) · Obesity · doi:10.1038/oby.2009.207 · Cited by 187 · see citing works
Self-citationMelanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass Surgery
Hatoum, I. J., Stylopoulos, N., Vanhoose, A. M., Boyd, K. L., Yin, D., Ellacott, K. L. J., Li, L., Blaszczyk, K., Keogh, J. M., Cone, R. D., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3432 · Cited by 159 · see citing works
Self-citationDeplancke, B., Hristova, K. R., Oakley, H. A., McCracken, V. J., Aminov, R. I., Mackie, R. I., & Gaskins, H. R. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.5.2166-2174.2000 · Cited by 159 · see citing works
Bellahcene, M., O’Dowd, J. F., Wargent, E. T., Zaibi, M. S., Hislop, D. C., Ngala, R. A., Smith, D. M., Cawthorne, M. A., Stocker, C. J., & Arch, J. R. S. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003923 · Cited by 132 · see citing works
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
Bikman, B. T., Zheng, D., Pories, W. J., Chapman, W. H. H., Pender, J. R., Bowden, R., Reed, M. A., Cortright, R. N., Tapscott, E. B., Houmard, J. A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1030 · Cited by 106 · see citing works
Heritability of the Weight Loss Response to Gastric Bypass Surgery
Hatoum, I. J., Greenawalt, D. M., Cotsapas, C. J., Reitman, M. L., Daly, M. J., & Kaplan, L. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1130 · Cited by 91 · see citing works
Self-citationNestoridi, E., Kvas, S., Kucharczyk, J. R., & Stylopoulos, N. (2012) · Endocrinology · doi:10.1210/en.2011-2041 · Cited by 85 · see citing works
Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917
Trebichavský, I., Šplı́chal, I., Rada, V., & Šplı́chalová, A. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00305.x · Cited by 70 · see citing works
Effect of propionate on lipogenesis in adipose tissue
Reshef, L., Niv, J., & Shapiro, B. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38892-1 · Cited by 32 · see citing works
Metabolic surgery for type 2 diabetes
Ahn, S. M., Pomp, A., & Rubino, F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05984.x · Cited by 25 · see citing works
Kucharczyk, J. R., Nestoridi, E., Kvas, S., Andrews, R. A. F., & Stylopoulos, N. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.02.036 · Cited by 16 · see citing works
Pharmacological and Molecular Characteristics
Parini, A. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32394.x · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works
Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works
Chambers, E. S., Viardot, A., Psichas, A., Morrison, D. J., Murphy, K. G., Zac-Varghese, S. E. K., MacDougall, K., Preston, T., Tedford, C., Finlayson, G. S., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307913 · Cited by 1,424 · see citing works
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
“The pig gut microbiota is becoming an increasingly intensive area of study owing to the scale of the pig husbandry industry, as well as to the similarities in anatomy, physiology and immunology to the human gastrointestinal tract (Litten-Brown et al., 2010).”
BackgroundMartin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307142 · Cited by 1,137 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works
Chávez-Talavera, O., Tailleux, A., Lefebvre, P., & Staels, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.055 · Cited by 970 · see citing works
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931 · see citing works
Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation
Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., & Kimura, I. (2015) · Nutrients · doi:10.3390/nu7042839 · Cited by 904 · see citing works
Psichas, A., Sleeth, M. L., Murphy, K. G., Brooks, L., Bewick, G. A., Hanyaloglu, A. C., Ghatei, M. A., Bloom, S. R., & Frost, G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.153 · Cited by 886 · see citing works
Gut Microbiota Orchestrates Energy Homeostasis during Cold
Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.004 · Cited by 829 · see citing works
Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.009 · Cited by 757 · see citing works
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
Spanogiannopoulos, P., Bess, E. N., Carmody, R. N., & Turnbaugh, P. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.17 · Cited by 717 · see citing works
Self-citationLi, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705 · see citing works
The role of short chain fatty acids in appetite regulation and energy homeostasis
Byrne, C. S., Chambers, E. S., Morrison, D. J., & Frost, G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.84 · Cited by 707 · see citing works
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z.-Z., Takahashi, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76738 · Cited by 693 · see citing works
Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678 · see citing works
Self-citationFunction and mechanisms of enteroendocrine cells and gut hormones in metabolism
Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0168-8 · Cited by 670 · see citing works
Insights into the role of the microbiome in obesity and type 2 diabetes
Hartstra, A. V., Bouter, K. E. C., Bäckhed, F., & Nieuwdorp, M. (2015) · Diabetes Care · doi:10.2337/dc14-0769 · Cited by 641 · see citing works
Gut Microbiota and Obesity: A Role for Probiotics
Abenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., Aiello, V., Romano, B., De Lorenzo, A., Izzo, A. A., et al. (2019) · Nutrients · doi:10.3390/nu11112690 · Cited by 615 · see citing works
Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook
Kelly, C. R., Kahn, S., Kashyap, P., Laine, L., Rubin, D., Atreja, A., Moore, T., & Wu, G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.008 · Cited by 572 · see citing works
The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.002 · Cited by 555 · see citing works
Interactions between gut bacteria and bile in health and disease
Long, S. L., Gahan, C. G. M., & Joyce, S. A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.002 · Cited by 495 · see citing works
Chambers, E. S., Byrne, C. S., Morrison, D. J., Murphy, K. G., Preston, T., Tedford, C., Garcia-Perez, I., Fountana, S., Serrano-Contreras, J. I., Holmes, E., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318424 · Cited by 443 · see citing works
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery
Aron-Wisnewsky, J., Prifti, E., Belda, E., Ichou, F., Kayser, B. D., Dao, M. C., Verger, E. O., Hedjazi, L., Bouillot, J.-L., Chevallier, J.-M., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316103 · Cited by 418 · see citing works
Role of the Microbiome in Energy Regulation and Metabolism
Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.008 · Cited by 421 · see citing works
Self-citationThe gut microbiome and its role in obesity
Davis, C. D. (2016) · Nutrition Today · doi:10.1097/nt.0000000000000167 · Cited by 407 · see citing works
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour
Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403 · see citing works
Microbiota depletion promotes browning of white adipose tissue and reduces obesity
Suárez-Zamorano, N., Fabbiano, S., Chevalier, C., Stojanović, O., Colin, D. J., Stevanović, A., Veyrat-Durebex, C., Tarallo, V., Rigo, D., Germain, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3994 · Cited by 403 · see citing works
Mechanisms of diabetes improvement following bariatric/metabolic surgery
Batterham, R. L., & Cummings, D. E. (2016) · Diabetes Care · doi:10.2337/dc16-0145 · Cited by 376 · see citing works
Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Miura, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7381 · Cited by 355 · see citing works
A diet-sensitive commensal Lactobacillus strain Mediates TLR7-dependent systemic autoimmunity
Zegarra-Ruiz, D. F., El Beidaq, A., Iñiguez, A. J., Lubrano Di Ricco, M., Manfredo Vieira, S., Ruff, W. E., Mubiru, D., Fine, R. L., Sterpka, J., Greiling, T. M., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.009 · Cited by 308 · see citing works
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
Kindt, A., Liebisch, G., Clavel, T., Haller, D., Hörmannsperger, G., Yoon, H., Kolmeder, D., Sigruener, A., Krautbauer, S., Seeliger, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05767-4 · Cited by 311 · see citing works
Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice
Zhao, S., Liu, W., Wang, J., Shi, J., Sun, Y., Wang, W., Ning, G., Liu, R., & Hong, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0054 · Cited by 298 · see citing works
Murphy, R., Tsai, P., Jüllig, M., Liu, A., Plank, L., & Booth, M. (2017) · Obesity Surgery · doi:10.1007/s11695-016-2399-2 · Cited by 285 · see citing works
Microbial modulation of insulin sensitivity
Khan, M. T., Nieuwdorp, M., & Bäckhed, F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.006 · Cited by 260 · see citing works
Joyce, S. A., & Gahan, C. G. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033159 · Cited by 241 · see citing works
Byrne, C. S., Chambers, E. S., Alhabeeb, H., Chhina, N., Morrison, D. J., Preston, T., Tedford, C., Fitzpatrick, J., Irani, C., Busza, A., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.126706 · Cited by 201 · see citing works
Rintala, A., Pietilä, S., Munukka, E., Eerola, E., Pursiheimo, J.-P., Laiho, A., Pekkala, S., & Huovinen, P. (2017) · Journal of Biomolecular Techniques : JBT · doi:10.7171/jbt.17-2801-003 · Cited by 194 · see citing works
Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188 · see citing works
“An increase of Proteobacteria may include a potential risk for bowel inflammation due to its pathogen traits [158].”
BackgroundGut microbiota interacts with brain microstructure and function
Fernandez-Real, J.-M., Serino, M., Blasco, G., Puig, J., Daunis-i-Estadella, J., Ricart, W., Burcelin, R., Fernández-Aranda, F., & Portero-Otin, M. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3076 · Cited by 167 · see citing works
Ahmad, N. N., Pfalzer, A., & Kaplan, L. M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.38 · Cited by 163 · see citing works
Self-citationNew mechanisms of metformin action: Focusing on mitochondria and the gut
Hur, K. Y., & Lee, M. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12328 · Cited by 161 · see citing works
Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review
Abdeen, G., & le Roux, C. (2016) · Obesity Surgery · doi:10.1007/s11695-015-1945-7 · Cited by 162 · see citing works
Feeding the microbiota: Transducer of nutrient signals for the host
Shanahan, F., van Sinderen, D., O’Toole, P. W., & Stanton, C. (2017) · Gut · doi:10.1136/gutjnl-2017-313872 · Cited by 157 · see citing works
Rubino, F., Nathan, D. M., Eckel, R. H., Schauer, P. R., Alberti, K. G. M. M., Zimmet, P. Z., Del Prato, S., Ji, L., Sadikot, S. M., Herman, W. H., et al. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.05.018 · Cited by 157 · see citing works
Self-citationDiet, gut microbiota and cognition
Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works
Gut Microbiota in Obesity and Undernutrition
de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140 · see citing works
Mechanisms of Weight Loss After Obesity Surgery
Akalestou, E., Miras, A. D., Rutter, G. A., & le Roux, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab022 · Cited by 136 · see citing works
Non-pharmacological Treatment Options in the Management of Diabetes Mellitus
Raveendran, A. V. (2018) · European Endocrinology · doi:10.17925/ee.2018.14.2.31 · Cited by 122 · see citing works
Biobaku, F., Ghanim, H., Batra, M., & Dandona, P. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01833 · Cited by 104 · see citing works
Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients
Medina, D. A., Pedreros, J. P., Turiel, D., Quezada, N., Pimentel, F., Escalona, A., & Garrido, D. (2017) · PeerJ · doi:10.7717/peerj.3443 · Cited by 101 · see citing works
Shen, N., Caixàs, A., Ahlers, M., Patel, K., Gao, Z., Dutia, R., Blaser, M. J., Clemente, J. C., & Laferrère, B. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.05.038 · Cited by 94 · see citing works
The gut microbiota as a mediator of metabolic benefits after bariatric surgery
Anhê, F. F., Varin, T. V., Schertzer, J. D., & Marette, A. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.02.002 · Cited by 93 · see citing works
Recent advances in clinical practice challenges and opportunities in the management of obesity
Acosta, A., Abu Dayyeh, B. K., Port, J. D., & Camilleri, M. (2014) · Gut · doi:10.1136/gutjnl-2013-306235 · Cited by 91 · see citing works
Gut adaptation after metabolic surgery and its influences on the brain, liver and cancer
Sinclair, P., Brennan, D. J., & le Roux, C. W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0057-y · Cited by 91 · see citing works
Tanca, A., Abbondio, M., Palomba, A., Fraumene, C., Marongiu, F., Serra, M., Pagnozzi, D., Laconi, E., & Uzzau, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33100-y · Cited by 79 · see citing works
Yang, Y., Shi, Y., Wiklund, P., Tan, X., Wu, N., Zhang, X., Tikkanen, O., Zhang, C., Munukka, E., & Cheng, S. (2017) · Nutrients · doi:10.3390/nu9080792 · Cited by 72 · see citing works
Leibel, R. L., Seeley, R. J., Darsow, T., Berg, E. G., Smith, S. R., & Ratner, R. (2015) · Diabetes · doi:10.2337/db15-0004 · Cited by 52 · see citing works
Gut Microbiome and Modulation of <scp>CNS</scp> Function
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c180031 · Cited by 53 · see citing works
Diabetes after Bariatric Surgery
Shah, A., & Laferrère, B. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.12.009 · Cited by 50 · see citing works
Incretin Hormones, Obesity and Gut Microbiota
Angelini, G., Russo, S., & Mingrone, G. (2024) · Peptides · doi:10.1016/j.peptides.2024.171216 · Cited by 47 · see citing works
Potential gut–brain mechanisms behind adverse mental health outcomes of bariatric surgery
Brown, R. M., Guerrero-Hreins, E., Brown, W. A., le Roux, C. W., & Sumithran, P. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00520-2 · Cited by 49 · see citing works
Mindikoglu, A. L., Opekun, A. R., Gagan, S. K., & Devaraj, S. (2017) · Gastroenterology Research and Practice · doi:10.1155/2017/3932491 · Cited by 49 · see citing works
Improved glucose metabolism after gastric bypass: evolution of the paradigm
Pournaras, D. J., Nygren, J., Hagström-Toft, E., Arner, P., le Roux, C. W., & Thorell, A. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.03.020 · Cited by 48 · see citing works
Bariatric surgery and diabetes remission: Who would have thought it?
Singh, A., Singh, R., & Kota, S. (2015) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.163113 · Cited by 48 · see citing works
Hu, C., Li, F., Duan, Y., Yin, Y., & Kong, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01767 · Cited by 41 · see citing works
Dagbasi, A., Lett, A. M., Murphy, K., & Frost, G. (2020) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120006941 · Cited by 44 · see citing works
Insulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches
Mulla, C. M., Storino, A., Yee, E. U., Lautz, D., Sawnhey, M. S., Moser, A. J., & Patti, M.-E. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2092-5 · Cited by 40 · see citing works
Applications of gut microbiota in patients with hematopoietic stem-cell transplantation
Yu, J., Sun, H., Cao, W., Han, L., Song, Y., Wan, D., & Jiang, Z. (2020) · Experimental Hematology & Oncology · doi:10.1186/s40164-020-00194-y · Cited by 25 · see citing works
- Authors
- Liou, A. P., Paziuk, M., Luevano, J.-M., Machineni, S., Turnbaugh, P. J., & Kaplan, L. M.
- Affiliations
- Massachusetts General Hospital (US)
- FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
- Harvard University (US)
- Corresponding author
- Turnbaugh, Peter J.
- Kaplan, Lee M.
- Venue
- Science Translational Medicine
- Published
- 2013-03-27
- Volume
- 5
- Issue
- 178
- Pages
- 178ra41-178ra41
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3652229
- OpenAlex
- W2157176317
- Cited by
- 1,007
- References
- 57
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 36 · 2023: 57 · 2022: 68 · 2021: 92 · 2020: 88 · 2019: 103 · 2018: 84 · 2017: 90 · 2016: 105 · 2015: 114 · 2014: 69 · 2013: 47
- FWCI
- 49.98
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM068763)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-088661, RC2DK088661, F32DK095561, P30DK034854, P30DK043351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Roux-en-Y gastric bypass, gut microbiota, bariatric surgery, weight loss, adiposity, host-microbe interactions, Akkermansia, Escherichia, Verrucomicrobia, Gammaproteobacteria, short-chain fatty acids, fecal microbiota transplantation, germ-free mice, caloric restriction
- MeSH terms
- Animals, Body Weight, Eating, Male, Mice, Inbred C57BL, Gastric Bypass, Gastrointestinal Tract, Adiposity, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
