Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
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The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse population and applied systems genetics strategies to identify interactions between host and microbe phenotypes including microbial functions, using faecal metagenomics, small intestinal transcripts and caecal lipids that influence microbe–host dynamics. Quantitative trait locus (QTL) mapping identified murine genomic regions associated with variations in bacterial taxa; bacterial functions including motility, sporulation and lipopolysaccharide production and levels of bacterial- and host-derived lipids. We found overlapping QTL for the abundance of Akkermansia muciniphila and caecal levels of ornithine lipids. Follow-up in vitro and in vivo studies revealed that A. muciniphila is a major source of these lipids in the gut, provided evidence that ornithine lipids have immunomodulatory effects and identified intestinal transcripts co-regulated with these traits including Atf3 , which encodes for a transcription factor that plays vital roles in modulating metabolism and immunity. Collectively, these results suggest that ornithine lipids are potentially important for A. muciniphila– host interactions and support the role of host genetics as a determinant of responses to gut microbes.
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A. muciniphila can modulate the immune system and influence the microbiota-host interaction through the production of immunomodulatory lipids.
“And A. muciniphila can modulate the immune system and influence the microbiota‐host interaction through the production of immunomodulatory lipids (Zhang et al., 2023).”
From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Zhang et al., 2023
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- Authors
- Zhang, Q., Linke, V., Overmyer, K. A., Traeger, L. L., Kasahara, K., Miller, I. J., Manson, D. E., Polaske, T. J., Kerby, R. L., Kemis, J. H., Trujillo, E. A., Reddy, T. R., Russell, J. D., Schueler, K. L., Stapleton, D. S., Rabaglia, M. E., Seldin, M., Gatti, D. M., Keele, G. R., Pham, D. T., Gerdt, J. P., Vivas, E. I., Lusis, A. J., Keller, M. P., Churchill, G. A., Blackwell, H. E., Broman, K. W., Attie, A. D., Coon, J. J., & Rey, F. E.
- Affiliations
- University of Wisconsin–Madison (US)
- University of California, Los Angeles (US)
- Jackson Laboratory (US)
- Indiana University Bloomington (US)
- Corresponding author
- Rey, F. E.
- ORCID
- Venue
- Nature Microbiology
- Published
- 2023-02-09
- Volume
- 8
- Issue
- 3
- Pages
- 424-440
- ISSN
- 2058-5276 (ISSN-L)
- PMC
- PMC9981464
- OpenAlex
- W4319825888
- Cited by
- 43
- References
- 84
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 19 · 2023: 9
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-03-27)
- Open access
- hybrid
- doi.org
- Locations
- Nature Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion, cc-by)
- Funders
- University of Wisconsin-Madison (HL144651, 5T15LM007359)
- University of Wisconsin Carbone Cancer Center
- European Commission
- Fondation Leducq (17CVD01)
- Fundacja na rzecz Nauki Polskiej (START 064.2022, MAB/20172)
- Narodowym Centrum Nauki (2021/40/C/NZ3/00283)
- National Institutes of Health (DK101573, DK108259)
- European Regional Development Fund (MAB/2017/2)
- National Heart, Lung, and Blood Institute (R01HL144651, R01HL148577)
- National Human Genome Research Institute (T32HG002760)
- National Institute of General Medical Sciences (R01GM070683, T32GM008505, R35GM138376, P41GM108538, R35GM131817)
- National Institute of Allergy and Infectious Diseases (T32 AI55397, T32AI055397)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK101573, R01DK108259, R01DK117850, T32DK007665, RC2DK125961)
- U.S. National Library of Medicine (T15LM007359)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Akkermansia muciniphila, ornithine lipids, immunomodulation, host-microbe interactions, host genetics, gut microbiota, quantitative trait loci, ATF3, bacterial motility, bacterial sporulation
- MeSH terms
- Gastrointestinal Microbiome, Akkermansia, Animals, Phenotype, Mice, Verrucomicrobia
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