Cited by 57Memory and Neural MechanismsSpatial Cognition and NavigationNeurogenesis and neuroplasticity mechanisms

Recurrent circuits within medial entorhinal cortex superficial layers support grid cell firing

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Zutshi, Ipshita, Fu, Maylin L., Lilascharoen, Varoth, Leutgeb, Jill K., Lim, Byung Kook, Leutgeb, Stefan·2018·Nature Communications

Abstract

Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb locally projecting layer II pyramidal cells. We find that sharply tuned HD cells are only weakly responsive while speed, broadly tuned HD cells, and grid cells show pronounced transient excitatory and inhibitory responses. During the brief period of feedback inhibition, there is a reduction in specifically grid accuracy, which is corrected as firing rates return to baseline. These results suggest that sharp HD cells are embedded in a separate mEC sub-network from broad HD cells, speed cells, and grid cells. Furthermore, grid tuning is not only dependent on local processing but also rapidly updated by HD, speed, or other afferent inputs to mEC.

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  • Spike downsampling was implemented by randomly removing spikes during immobility periods from behaviorally-modulated units to match the median firing rate of non-modulated units.

    “Spike downsampling was implemented by randomly removing spikes during immobility periods from behaviorally-modulated units to match the median firing rate of non-modulated units (Supplementary Figs. 6b and 3g)135,136.”

    From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [136]

    The Methods section (“Measuring effects of optical stimulation: Speed tuning”; page unavailable) describes randomly selecting spikes before light onset to match the number of spikes during maximal inhibition. It does not describe removing spikes during immobility from behaviorally modulated units or matching the median firing rate of non-modulated units. (LLM, conf=0.85)

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Authors
Zutshi, I., Fu, M. L., Lilascharoen, V., Leutgeb, J. K., Lim, B. K., & Leutgeb, S.
Affiliations
University of California San Diego (US)
Corresponding author
Leutgeb, Stefan
Venue
Nature Communications
Published
2018-09-12
Volume
9
Issue
1
Pages
3701-3701
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2892282934
Cited by
57
References
63
Citations by year
2026: 4 · 2025: 11 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 12 · 2020: 5 · 2019: 5
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • Whitehall Foundation (20130571)
  • National Institutes of Health
  • National Institute of Mental Health (R01MH108594, R01MH100349, R01MH107742)
  • National Institute of Neurological Disorders and Stroke (R01NS084324, R01NS086947, R01NS097772, R01NS102915)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
medial entorhinal cortex, grid cells, head direction cells, recurrent circuits, local circuits, product inhibition, optogenetic perturbation, spatial navigation, afferent input
MeSH terms
Grid Cells, Action Potentials, Animals, Female, Male, Pyramidal Cells, Entorhinal Cortex, Spatial Navigation

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