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Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex

Buetfering, Christina, Allen, Kevin, Monyer, Hannah·2014·Nature Neuroscience

Abstract

Grid cells in the medial entorhinal cortex (MEC) generate metric spatial representations. Recent attractor-network models suggest an essential role for GABAergic interneurons in the emergence of the grid-cell firing pattern through recurrent inhibition dependent on grid-cell phase. To test this hypothesis, we studied identified parvalbumin-expressing (PV(+)) interneurons that are the most likely candidate for providing this recurrent inhibition onto grid cells. Using optogenetics and tetrode recordings in mice, we found that PV(+) interneurons exhibited high firing rates, low spatial sparsity and no spatial periodicity. PV(+) interneurons inhibited all functionally defined cell types in the MEC and were in turn recruited preferentially by grid cells. To our surprise, we found that individual PV(+) interneurons received input from grid cells with various phases, which most likely accounts for the broadly tuned spatial firing activity of PV(+) interneurons. Our data argue against the notion that PV(+) interneurons provide phase-dependent recurrent inhibition and challenge recent attractor-network models of grid cells.

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Crossref · 10.1038/nn.3696

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  • Spike downsampling was implemented by randomly removing spikes during immobility periods from behaviorally-modulated units to match the median firing rate of non-modulated units.

    “Spike downsampling was implemented by randomly removing spikes during immobility periods from behaviorally-modulated units to match the median firing rate of non-modulated units (Supplementary Figs. 6b and 3g)135,136.”

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Authors
Buetfering, C., Allen, K., & Monyer, H.
Affiliations
German Cancer Research Center (DE)
Corresponding author
Monyer, Hannah
Venue
Nature Neuroscience
Published
2014-04-06
Volume
17
Issue
5
Pages
710-718
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2068578235
Cited by
160
References
46
Citations by year
2026: 8 · 2025: 4 · 2024: 17 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 12 · 2019: 6 · 2018: 17 · 2017: 20 · 2016: 15 · 2015: 17 · 2014: 8
FWCI
11.15
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministerio de Economía y Competitividad
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
parvalbumin interneurons, medial entorhinal cortex, grid cells, recurrent inhibition, spatial tuning, head direction cells, GABAergic interneurons, spatial representation, optogenetic stimulation
MeSH terms
Channelrhodopsins, Red Fluorescent Protein, Action Potentials, Dependovirus, Animals, Humans, Interneurons, Lasers, Luminescent Proteins, Microinjections, Models, Neurological, Nerve Net, Neural Inhibition, Parvalbumins, Theta Rhythm, Transduction, Genetic, Statistics, Nonparametric, Entorhinal Cortex, Maze Learning, Mice

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