Awake hippocampal sharp-wave ripples support spatial memory
Open accessAbstract
Spatial Memory Perturbation: The hippocampus is important for learning and memory. However, it is not clear which patterns of neural activity in the hippocampus support specific mnemonic functions. Jadhav et al. (p. 1454 , published online 3 May) developed a real-time analysis system to detect and selectively interrupt a certain type of hippocampal neuronal network event—sharp-wave ripples—during learning. In awake animals, loss of sharp-wave ripples and associated memory replay activity caused a learning deficit specific to spatial working memory but had no effect on reference memory. This learning deficit was present despite the preservation of place-field representations and replay activity during rest.
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Wake replay is expected not to interfere with consolidation only when it is not offline but occurs briefly after encoding in the very same context as the encoded event.
“Along this line, wake replay is expected not to interfere with consolidation only when it is not ''offline'' but occurs briefly after encoding in the very same context as the encoded event.284,285,293”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [285]
The Abstract describes awake replay during learning and distinguishes its role from rest/sleep SWR activity associated with consolidation. It does not say that wake replay avoids interfering with consolidation only if it occurs briefly after encoding in the same context; that timing and exclusivity condition is unsupported. (LLM, conf=0.76)
Experimental — accuracy not yet measuredMessage passing-based planning in CSCGs involves forward and backward sweeps from the current state, and is akin to replays in the hippocampus.
“Such message passing–based planning in CSCGs involves forward and backward sweeps from the current state, and is akin to replays in the hippocampus (38, 39).”
From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [39]
Disturbing wake replay activity impairs memory formation, indicating that neuronal reactivations of newly formed representations represent a common core process for consolidation during sleep and wakefulness.
“Disturbing such wake replay activity has also been found to impair memory formation, 284,285 indicating that neuronal reactivations of newly formed representations represent a common core process for consolidation during sleep and wakefulness.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [285]
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Cites
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118 · see citing works
Dynamics of the Hippocampal Ensemble Code for Space
Wilson, M. A., & McNaughton, B. L. (1993) · Science · doi:10.1126/science.8351520 · Cited by 2,350 · see citing works
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018 · see citing works
Reverse replay of behavioural sequences in hippocampal place cells during the awake state
Foster, D. J., & Wilson, M. A. (2006) · Nature · doi:10.1038/nature04587 · Cited by 1,727 · see citing works
Selective suppression of hippocampal ripples impairs spatial memory
Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G., & Zugaro, M. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2384 · Cited by 1,560 · see citing works
Forward and reverse hippocampal place-cell sequences during ripples
Diba, K., & Buzsáki, G. (2007) · Nature Neuroscience · doi:10.1038/nn1961 · Cited by 1,205 · see citing works
Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval
Carr, M. F., Jadhav, S. P., & Frank, L. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2732 · Cited by 958 · see citing works
Self-citationThe Hippocampo-Neocortical Dialogue
Buzsáki, G. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.81 · Cited by 938 · see citing works
Hippocampal sharp waves: Their origin and significance
Buzsáki, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91483-6 · Cited by 925 · see citing works
Disruption of ripple‐associated hippocampal activity during rest impairs spatial learning in the rat
Ego‐Stengel, V., & Wilson, M. A. (2010) · Hippocampus · doi:10.1002/hipo.20707 · Cited by 842 · see citing works
Hippocampal replay of extended experience
Davidson, T. J., Kloosterman, F., & Wilson, M. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.027 · Cited by 806 · see citing works
Awake replay of remote experiences in the hippocampus
Karlsson, M. P., & Frank, L. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2344 · Cited by 769 · see citing works
Self-citationThe reorganization and reactivation of hippocampal maps predict spatial memory performance
Dupret, D., O'Neill, J., Pleydell-Bouverie, B., & Csicsvari, J. (2010) · Nature Neuroscience · doi:10.1038/nn.2599 · Cited by 769 · see citing works
Kudrimoti, H. S., Barnes, C. A., & McNaughton, B. L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04090.1999 · Cited by 753 · see citing works
Hippocampal replay is not a simple function of experience
Gupta, A. S., van der Meer, M. A. A., Touretzky, D. S., & Redish, A. D. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.034 · Cited by 733 · see citing works
Reversible neural inactivation reveals hippocampal participation in several memory processes
Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V. L., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. (1999) · Nature Neuroscience · doi:10.1038/13202 · Cited by 478 · see citing works
Feed-forward inhibition in the hippocampal formation
BUZSAKI, G. (1984) · Progress in Neurobiology · doi:10.1016/0301-0082(84)90023-6 · Cited by 453 · see citing works
Play it again: reactivation of waking experience and memory
O’Neill, J., Pleydell-Bouverie, B., Dupret, D., & Csicsvari, J. L. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.006 · Cited by 448 · see citing works
Rewarded Outcomes Enhance Reactivation of Experience in the Hippocampus
Singer, A. C., & Frank, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.016 · Cited by 385 · see citing works
Self-citationSpatial memory dissociations in mice lacking GluR1
Reisel, D., Bannerman, D. M., Schmitt, W. B., Deacon, R. M. J., Jonathan Flint, C., Borchardt, T., Seeburg, P. H., & Rawlins, J. N. P. (2002) · Nature Neuroscience · doi:10.1038/nn910 · Cited by 343 · see citing works
Reactivation of experience-dependent cell assembly patterns in the hippocampus
O'Neill, J., Senior, T. J., Allen, K., Huxter, J. R., & Csicsvari, J. (2008) · Nature Neuroscience · doi:10.1038/nn2037 · Cited by 318 · see citing works
Dynamic Analysis of Learning in Behavioral Experiments
Smith, A. C., Frank, L. M., Wirth, S., Yanike, M., Hu, D., Kubota, Y., Graybiel, A. M., SUZUKI, W. A., & Brown, E. N. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2908-03.2004 · Cited by 313 · see citing works
Self-citationNew Experiences Enhance Coordinated Neural Activity in the Hippocampus
Cheng, S., & Frank, L. M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.035 · Cited by 286 · see citing works
Self-citationO'Neill, J., Senior, T., & Csicsvari, J. (2006) · Neuron · doi:10.1016/j.neuron.2005.10.037 · Cited by 281 · see citing works
Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory
Murray, A., Sauer, J., Riedel, G., McClure, C., Ansel-Bollepalli, L., Cheyne, L., Bartos, M., Wisden, W., & Wulff, P. (2011) · Nature Neuroscience · doi:10.1038/nn.2751 · Cited by 276 · see citing works
Place Representation within Hippocampal Networks Is Modified by Long-Term Potentiation
Dragoi, G., Harris, K. D., & Buzsáki, G. (2003) · Neuron · doi:10.1016/s0896-6273(03)00465-3 · Cited by 215 · see citing works
Spike phase precession persists after transient intrahippocampal perturbation
Zugaro, M., Monconduit, L., & Buzsáki, G. (2004) · Nature Neuroscience · doi:10.1038/nn1369 · Cited by 125 · see citing works
Hippocampal Lesions Impair Rapid Learning of a Continuous Spatial Alternation Task
Kim, S. M., & Frank, L. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005494 · Cited by 95 · see citing works
Self-citationCommissural and perforant path interactions in the rat hippocampus
Buzs�ki, G., & Cz�h, G. (1981) · Experimental Brain Research · doi:10.1007/bf00238387 · Cited by 69 · see citing works
Different tests for a difference: how do we do research?
Drummond, G. B., & Vowler, S. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.225235 · Cited by 44 · see citing works
Small Group Statistics: A Monte Carlo Comparison of Parametric and Randomization Tests
Ninness, C., Newton, R., Saxon, J., et al. (2002) · Behavior and Social Issues · doi:10.5210/bsi.v12i1.79 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [2]Eichenbaum H Cohen NJ From Conditioning to Conscious Recollection Oxford Univ. Press New York 2001
- [5]O’Keefe J Nadel L The Hippocampus as a Cognitive Map Oxford Univ. Press London 1978
- [8]O’Neill J Senior T Csicsvari J Neuron 49 143 2006 16387646
- [18]Ego-Stengel V Wilson MA Hippocampus 20 1 2010 19816984 PMC2801761
- [28]O’Neill J Senior TJ Allen K Huxter JR Csicsvari J Nat Neurosci 11 209 2008 18193040
Cited by
Sorted by citations
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works
Hippocampal place-cell sequences depict future paths to remembered goals
Pfeiffer, B. E., & Foster, D. J. (2013) · Nature · doi:10.1038/nature12112 · Cited by 1,216 · see citing works
Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087 · see citing works
Time cells in the hippocampus: a new dimension for mapping memories
Eichenbaum, H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3827 · Cited by 843 · see citing works
Viewpoints: how the hippocampus contributes to memory, navigation and cognition
Lisman, J., Buzsáki, G., Eichenbaum, H., Nadel, L., Ranganath, C., & Redish, A. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4661 · Cited by 851 · see citing works
Navigating cognition: Spatial codes for human thinking
Bellmund, J. L. S., Gärdenfors, P., Moser, E. I., & Doeller, C. F. (2018) · Science · doi:10.1126/science.aat6766 · Cited by 643 · see citing works
Squire, L. R., Genzel, L., Wixted, J. T., & Morris, R. G. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021766 · Cited by 700 · see citing works
Rhythms of the hippocampal network
Colgin, L. L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.21 · Cited by 654 · see citing works
Human replay spontaneously reorganizes experience
Liu, Y., Dolan, R. J., Kurth-Nelson, Z., & Behrens, T. E. J. (2019) · Cell · doi:10.1016/j.cell.2019.06.012 · Cited by 497 · see citing works
Long-duration hippocampal sharp wave ripples improve memory
Fernández-Ruiz, A., Oliva, A., Fermino de Oliveira, E., Rocha-Almeida, F., Tingley, D., & Buzsáki, G. (2019) · Science · doi:10.1126/science.aax0758 · Cited by 490 · see citing works
The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation
Joo, H. R., & Frank, L. M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0077-1 · Cited by 430 · see citing works
Self-citationFoster, D. J. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031538 · Cited by 375 · see citing works
The Role of Hippocampal Replay in Memory and Planning
Ólafsdóttir, H. F., Bush, D., & Barry, C. (2018) · Current Biology · doi:10.1016/j.cub.2017.10.073 · Cited by 413 · see citing works
Hippocampal theta sequences reflect current goals
Wikenheiser, A. M., & Redish, A. D. (2015) · Nature Neuroscience · doi:10.1038/nn.3909 · Cited by 367 · see citing works
A cortical-hippocampal-cortical loop of information processing during memory consolidation
Rothschild, G., Eban, E., & Frank, L. M. (2017) · Nature Neuroscience · doi:10.1038/nn.4457 · Cited by 387 · see citing works
Self-citationSleep—A brain-state serving systems memory consolidation
Brodt, S., Inostroza, M., Niethard, N., & Born, J. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.005 · Cited by 343 · see citing works
Reverse replay of hippocampal place cells is uniquely modulated by changing reward
Ambrose, R. E., Pfeiffer, B. E., & Foster, D. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.047 · Cited by 292 · see citing works
Cognitive impairment in epilepsy: the role of network abnormalities
Holmes, G. L. (2015) · Epileptic Disorders · doi:10.1684/epd.2015.0739 · Cited by 334 · see citing works
Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory
Vaz, A. P., Inati, S. K., Brunel, N., & Zaghloul, K. A. (2019) · Science · doi:10.1126/science.aau8956 · Cited by 267 · see citing works
Hippocampal CA2 sharp-wave ripples reactivate and promote social memory
Oliva, A., Fernández-Ruiz, A., Leroy, F., & Siegelbaum, S. A. (2020) · Nature · doi:10.1038/s41586-020-2758-y · Cited by 268 · see citing works
Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior
Robinson, N. T. M., Descamps, L. A. L., Russell, L. E., Buchholz, M. O., Bicknell, B. A., Antonov, G. K., Lau, J. Y. N., Nutbrown, R., Schmidt-Hieber, C., & Häusser, M. (2020) · Cell · doi:10.1016/j.cell.2020.09.061 · Cited by 281 · see citing works
Varga, C., Golshani, P., & Soltesz, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210929109 · Cited by 253 · see citing works
Sharp wave ripples during learning stabilize the hippocampal spatial map
Roux, L., Hu, B., Eichler, R., Stark, E., & Buzsáki, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4543 · Cited by 229 · see citing works
Persistence of hippocampal multivoxel patterns into postencoding rest is related to memory
Tambini, A., & Davachi, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308499110 · Cited by 230 · see citing works
Awake reactivation predicts memory in humans
Staresina, B. P., Alink, A., Kriegeskorte, N., & Henson, R. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311989110 · Cited by 219 · see citing works
Internally generated sequences in learning and executing goal-directed behavior
Pezzulo, G., van der Meer, M. A. A., Lansink, C. S., & Pennartz, C. M. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.06.011 · Cited by 217 · see citing works
Shin, J. D., Tang, W., & Jadhav, S. P. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.012 · Cited by 199 · see citing works
Self-citationHippocampal awake replay in fear memory retrieval
Wu, C.-T., Haggerty, D., Kemere, C., & Ji, D. (2017) · Nature Neuroscience · doi:10.1038/nn.4507 · Cited by 210 · see citing works
Self-citationVTA neurons coordinate with the hippocampal reactivation of spatial experience
Gomperts, S. N., Kloosterman, F., & Wilson, M. A. (2015) · eLife · doi:10.7554/elife.05360 · Cited by 191 · see citing works
Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., et al. (2016) · eLife · doi:10.7554/elife.20362 · Cited by 194 · see citing works
Assembly-specific disruption of hippocampal replay leads to selective memory deficit
Gridchyn, I., Schoenenberger, P., O’Neill, J., & Csicsvari, J. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.021 · Cited by 178 · see citing works
Hippocampal Replay Captures the Unique Topological Structure of a Novel Environment
Wu, X., & Foster, D. J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3414-13.2014 · Cited by 201 · see citing works
Memory trace replay: The shaping of memory consolidation by neuromodulation
Atherton, L. A., Dupret, D., & Mellor, J. R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.07.004 · Cited by 180 · see citing works
Gillespie, A. K., Jones, E. A., Lin, Y.-H., Karlsson, M. P., Kay, K., Yoon, S. Y., Tong, L. M., Nova, P., Carr, J. S., Frank, L. M., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.009 · Cited by 187 · see citing works
Self-citationHippocampal-prefrontal reactivation during learning is stronger in awake compared with sleep states
Tang, W., Shin, J. D., Frank, L. M., & Jadhav, S. P. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2291-17.2017 · Cited by 160 · see citing works
Self-citationSuperficial layers of the medial entorhinal cortex replay independently of the hippocampus
O’Neill, J., Boccara, C. N., Stella, F., Schoenenberger, P., & Csicsvari, J. (2017) · Science · doi:10.1126/science.aag2787 · Cited by 177 · see citing works
Hippocampal sharp-wave ripples in waking and sleeping states
Roumis, D. K., & Frank, L. M. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.05.001 · Cited by 155 · see citing works
Self-citationSpatial goal coding in the hippocampal formation
Nyberg, N., Duvelle, É., Barry, C., & Spiers, H. J. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.012 · Cited by 141 · see citing works
Replay of behavioral sequences in the medial prefrontal cortex during rule switching
Kaefer, K., Nardin, M., Blahna, K., & Csicsvari, J. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.015 · Cited by 120 · see citing works
The why, what, where, when and how of goal-directed choice: neuronal and computational principles
Verschure, P. F. M. J., Pennartz, C. M. A., & Pezzulo, G. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0483 · Cited by 131 · see citing works
“…retrieval is thought to take place as ‘replay’ mainly occurring during hippocampal local-field potential (LFP) events called sharp-wave ripples [85–88], but also during bouts of LFP theta-band activity during running and other ongoing behaviour, resulting in ‘forward sweeps’ of hippocampal place…”
BackgroundManipulating a “Cocaine Engram” in Mice
Hsiang, H.-L. (., Epp, J. R., van den Oever, M. C., Yan, C., Rashid, A. J., Insel, N., Ye, L., Niibori, Y., Deisseroth, K., Frankland, P. W., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-14.2014 · Cited by 131 · see citing works
Respiration modulates olfactory memory consolidation in humans.
Arshamian, A., Iravani, B., Majid, A., & Lundström, J. N. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3360-17.2018 · Cited by 115 · see citing works
Bergel, A., Deffieux, T., Demené, C., Tanter, M., & Cohen, I. (2018) · Nature Communications · doi:10.1038/s41467-018-07752-3 · Cited by 117 · see citing works
Paying the brain's energy bill
Padamsey, Z., & Rochefort, N. L. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102668 · Cited by 114 · see citing works
Reward revaluation biases hippocampal replay content away from the preferred outcome
Carey, A. A., Tanaka, Y., & van der Meer, M. A. A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0464-6 · Cited by 106 · see citing works
Post-learning hippocampal replay selectively reinforces spatial memory for highly rewarded locations
Michon, F., Sun, J.-J., Kim, C. Y., Ciliberti, D., & Kloosterman, F. (2019) · Current Biology · doi:10.1016/j.cub.2019.03.048 · Cited by 86 · see citing works
Hippocampo-cortical circuits for selective memory encoding, routing, and replay
Harvey, R. E., Robinson, H. L., Liu, C., Oliva, A., & Fernandez-Ruiz, A. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.015 · Cited by 101 · see citing works
Episodic Memory in Nonhuman Animals
Templer, V. L., & Hampton, R. R. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.016 · Cited by 94 · see citing works
Neuronal Responses to Conspecifics in the Ventral CA1
Rao, R. P., von Heimendahl, M., Bahr, V., & Brecht, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.081 · Cited by 85 · see citing works
How the Brain’s Navigation System Shapes Our Visual Experience
Nau, M., Julian, J. B., & Doeller, C. F. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.06.008 · Cited by 79 · see citing works
Cortical–hippocampal coupling during manifold exploration in motor cortex
Kim, J., Joshi, A., Frank, L., & Ganguly, K. (2023) · Nature · doi:10.1038/s41586-022-05533-z · Cited by 77 · see citing works
Self-citationThe sleep benefit in episodic memory: An integrative review and a meta-analysis.
Berres, S., & Erdfelder, E. (2021) · Psychological Bulletin · doi:10.1037/bul0000350 · Cited by 74 · see citing works
Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits
Tang, W., Shin, J. D., & Jadhav, S. P. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112246 · Cited by 59 · see citing works
Self-citationRecurrent circuits within medial entorhinal cortex superficial layers support grid cell firing
Zutshi, I., Fu, M. L., Lilascharoen, V., Leutgeb, J. K., Lim, B. K., & Leutgeb, S. (2018) · Nature Communications · doi:10.1038/s41467-018-06104-5 · Cited by 57 · see citing works
Consciousness, Representation, Action: The Importance of Being Goal-Directed
Pennartz, C. M. A. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.10.006 · Cited by 49 · see citing works
Replay of incidentally encoded episodic memories in the rat
Sheridan, C. L., Lang, S., Knappenberger, M., Albers, C., Loper, R., Tillett, B., Sanchez, J., Wilcox, A., Harrison, T., Panoz-Brown, D., et al. (2024) · Current Biology · doi:10.1016/j.cub.2023.12.043 · Cited by 40 · see citing works
Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
Almeida-Filho, D. G., Queiroz, C. M., & Ribeiro, S. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2886-9 · Cited by 38 · see citing works
Ribeiro, S., & Stickgold, R. (2014) · Trends in Neuroscience and Education · doi:10.1016/j.tine.2014.02.004 · Cited by 37 · see citing works
Space is a latent sequence: A theory of the hippocampus
Raju, R. V., Guntupalli, J. S., Zhou, G., Wendelken, C., Lázaro-Gredilla, M., & George, D. (2024) · Science Advances · doi:10.1126/sciadv.adm8470 · Cited by 25 · see citing works
The generative grammar of the brain: a critique of internally generated representations
Dragoi, G. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00763-0 · Cited by 28 · see citing works
The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic
Hall, A. F., & Wang, D. V. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102396 · Cited by 23 · see citing works
Olcese, U., Bos, J. J., Vinck, M., & Pennartz, C. M. A. (2018) · Sleep · doi:10.1093/sleep/zsy167 · Cited by 18 · see citing works
Kajiya, R., Miyawaki, H., Nakahara, H., & Mizuseki, K. (2025) · eneuro · doi:10.1523/eneuro.0575-24.2025 · Cited by 4 · see citing works
Amer, T., & Davachi, L. (2022) · doi:10.31234/osf.io/32egy · Cited by 3 · see citing works
- Authors
- Jadhav, S. P., Kemere, C., German, P. W., & Frank, L. M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Frank, Loren M.
- Venue
- Science
- Published
- 2012-06-15
- Volume
- 336
- Issue
- 6087
- Pages
- 1454-1458
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4441285
- OpenAlex
- W2085256822
- Semantic Scholar
- eb4f496dce54d0ab163779972872df2747c58e08
- Cited by
- 924
- References
- 32
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- FWCI
- 24.71
- Type
- journal article
- Language
- en
- Update notices
- correction (2026-07-09)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH080283)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampus, sharp-wave ripples, spatial memory, spatial learning, memory replay, memory-guided decision-making
- MeSH terms
- Animals, Decision Making, Electric Stimulation, Hippocampus, Male, Memory, Memory, Short-Term, Nerve Net, Space Perception, Wakefulness, Maze Learning, Rats, Long-Evans, Rats, Synaptic Potentials, CA1 Region, Hippocampal, Brain Waves
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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