The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis
Open accessAbstract
Cancer-derived exosomes are considered a major driver of cancer-induced pre-metastatic niche formation at foreign sites, but the mechanisms remain unclear. Here, we show that miR-25-3p, a metastasis-promoting miRNA of colorectal cancer (CRC), can be transferred from CRC cells to endothelial cells via exosomes. Exosomal miR-25-3p regulates the expression of VEGFR2, ZO-1, occludin and Claudin5 in endothelial cells by targeting KLF2 and KLF4, consequently promotes vascular permeability and angiogenesis. In addition, exosomal miR-25-3p from CRC cells dramatically induces vascular leakiness and enhances CRC metastasis in liver and lung of mice. Moreover, the expression level of miR-25-3p from circulating exosomes is significantly higher in CRC patients with metastasis than those without metastasis. Our work suggests that exosomal miR-25-3p is involved in pre-metastatic niche formation and may be used as a blood-based biomarker for CRC metastasis.
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Tumour exosome integrins determine organotropic metastasis
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Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
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Metadata
- Authors
- Zeng, Z., Li, Y., Pan, Y., Lan, X., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., Hu, J., Zhu, X., Yang, W., Liao, W., Li, G., Ding, Y., & Liang, L.
- Venue
- Nature Communications
- Published
- 2018-12-19
- Volume
- 9
- Issue
- 1
- Pages
- 5395-5395
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2904628185
- Cited by
- 992
- References
- 6
- FWCI
- 28.02
- Type
- journal article
- Language
- en
- Open access
- gold
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