The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Open accessAbstract
Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways potential therapeutic targets. Here, by exploring a lipid library, we show that AM580, a retinoid derivative and RAR-α agonist, is highly potent in interrupting the life cycle of diverse viruses including Middle East respiratory syndrome coronavirus and influenza A virus. Using click chemistry, the overexpressed sterol regulatory element binding protein (SREBP) is shown to interact with AM580, which accounts for its broad-spectrum antiviral activity. Mechanistic studies pinpoint multiple SREBP proteolytic processes and SREBP-regulated lipid biosynthesis pathways, including the downstream viral protein palmitoylation and double-membrane vesicles formation, that are indispensable for virus replication. Collectively, our study identifies a basic lipogenic transactivation event with broad relevance to human viral infections and represents SREBP as a potential target for the development of broad-spectrum antiviral strategies.
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Self-citationZhou, Y., Hou, Y., Shen, J., Mehra, R., Kallianpur, A., Culver, D. A., Gack, M. U., Farha, S., Zein, J., Comhair, S., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000970 · Cited by 180
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Structural basis for sterol sensing by Scap and Insig
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Wang, Y., Wang, Y., Ding, L., Ren, X., Wang, B., Wang, L., Zhao, S., Yue, X., Wu, Z., Li, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111738 · Cited by 27
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Metadata
- Authors
- Yuan, S., Chu, H., Chan, J. F.-W., Ye, Z.-W., Wen, L., Yan, B., Lai, P.-M., Tee, K.-M., Huang, J., Chen, D., Li, C., Zhao, X., Yang, D., Chiu, M. C., Yip, C., Poon, V. K.-M., Chan, C. C.-S., Sze, K.-H., Zhou, J., Chan, I. H.-Y., Kok, K.-H., To, K. K.-W., Kao, R. Y.-T., Lau, J. Y.-N., Jin, D.-Y., Perlman, S., & Yuen, K.-Y.
- Venue
- Nature Communications
- Published
- 2019-01-10
- Volume
- 10
- Issue
- 1
- Pages
- 120-120
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2908901070
- Cited by
- 253
- References
- 65
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yuan, S., Chu, H., Chan, J. F.-W., Ye, Z.-W., Wen, L., Yan, B., Lai, P.-M., Tee, K.-M., Huang, J., Chen, D., Li, C., Zhao, X., Yang, D., Chiu, M. C., Yip, C., Poon, V. K.-M., Chan, C. C.-S., Sze, K.-H., Zhou, J., . . . Yuen, K.-Y. (2019). SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nature Communications. https://doi.org/10.1038/s41467-018-08015-x
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