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Structural basis for sterol sensing by Scap and Insig
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SCAP is a cholesterol sensor that regulates intracellular cholesterol homeostasis through signal transduction.
“Sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) is a cholesterol sensor that regulates intracellular cholesterol homeostasis through signal transduction16–18.”
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Structural basis for the recognition of Sonic Hedgehog by human Patched1
Gong, X., Qian, H., Cao, P., Zhao, X., Zhou, Q., Lei, J., & Yan, N. (2018) · Science · doi:10.1126/science.aas8935 · Cited by 216
Self-citationA structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols
Yan, R., Cao, P., Song, W., Qian, H., Du, X., Coates, H. W., Zhao, X., Li, Y., Gao, S., Gong, X., et al. (2021) · Science · doi:10.1126/science.abb2224 · Cited by 100
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Metadata
- Authors
- Yan, R., Cao, P., Song, W., Li, Y., Wang, T., Qian, H., Yan, C., & Yan, N.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 35
- Issue
- 13
- Pages
- 109299
- ISSN
- 2211-1247
- Cited by
- 43
- References
- 2
- Language
- en
- Licence
- Funders
- Tsinghua University
- Princeton University
- Beijing Nova Program (Z201100006820039)
- Westlake University
- National Postdoctoral Program for Innovative Talents (BX20200304)
- National Natural Science Foundation of China
- National Key Research and Development Program of China (2020YFA0509301)
- China Postdoctoral Science Foundation (2020M681937)
- Ministry of Science and Technology of the People's Republic of China
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