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Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling

Wang, T. S., Coppens, I., Saorin, A., Brady, N. R., & Hamacher‐Brady, A. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.014 · Cited by 49 · see citing works

USP15 antagonizes CRL4 CRBN -mediated ubiquitylation of glutamine synthetase and neosubstrates

Nguyen, T. V. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111391118 · Cited by 49 · see citing works

Deubiquitinases as novel therapeutic targets for diseases

Xian, Y., Ye, J., Tang, Y., Zhang, N., Peng, C. Y., Huang, W., & He, G. (2024) · MedComm · doi:10.1002/mco2.70036 · Cited by 49 · see citing works

USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells

Lu, Q., Zhang, F.-L., Lu, D., Shao, Z., & Li, D. (2019) · Cancer Medicine · doi:10.1002/cam4.2528 · Cited by 43 · see citing works

The Multifaceted Roles of USP15 in Signal Transduction

Das, T., Song, E. J., & Kim, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094728 · Cited by 39 · see citing works

BARD1 mystery: tumor suppressors are cancer susceptibility genes

Hawsawi, Y. M., Shams, A. M., Theyab, A., Abdali, W. A., Hussien, N. A., Alatwi, H. E., Alzahrani, O. R., Oyouni, A. A. A., Babalghith, A. O., & Alreshidi, M. M. (2022) · BMC Cancer · doi:10.1186/s12885-022-09567-4 · Cited by 43 · see citing works

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Szczepanek, J., & Tretyn, A. (2023) · Biomolecules · doi:10.3390/biom13111590 · Cited by 43 · see citing works

BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

Perkail, S., Andricovich, J., Yan, K., & Tzatsos, A. (2020) · Nature Communications · doi:10.1038/s41467-020-16589-8 · Cited by 39 · see citing works

Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway

Zhong, M., Zhou, L., Fang, Z., Yao, Y., Zou, J., Xiong, J., Xiang, X., & Deng, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i26.4221 · Cited by 38 · see citing works

USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets

Li, Y.-C., Cai, S., Shu, Y.-B., Chen, M., & Shi, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10020474 · Cited by 38 · see citing works

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Kliche, J., & Ivarsson, Y. (2022) · Biochemical Journal · doi:10.1042/bcj20200714 · Cited by 34 · see citing works

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

Gao, M., Guo, G., Huang, J., Kloeber, J. A., Zhao, F., Deng, M., Tu, X., Kim, W., Zhou, Q., Zhang, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19202-0 · Cited by 34 · see citing works

E3 ubiquitin ligases and deubiquitinases in colorectal cancer: Emerging molecular insights and therapeutic opportunities

Kumar, S., Basu, M., & Ghosh, M. K. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119827 · Cited by 33 · see citing works

Ubiquitin specific peptidase 11 as a novel therapeutic target for cancer management

Liao, Y., Zhou, D., Wang, P., Yang, M., & Jiang, N. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01083-5 · Cited by 32 · see citing works

Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatment

Huang, M., Shen, G.-T., & Li, N. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i32.11690 · Cited by 27 · see citing works

PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair

Yu, Y., Liu, T., Yu, G., Wang, H., Du, Z., Chen, Y., Yang, N., Cao, K., Liu, C., Wan, Z., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05402-7 · Cited by 26 · see citing works

Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status

Varanda, A. B., Martins-Logrado, A., Ferreira, M. G., & Fior, R. (2020) · Cancers · doi:10.3390/cancers12071769 · Cited by 23 · see citing works

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

van den Berk, P. C. M., Lancini, C., Serresi, M., Sánchez-Bailón, M. P., Hulsman, D., Pritchard, C., Song, J., Schmitt, M. J., Tanger, E., Popp, O., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108533 · Cited by 25 · see citing works

Role of deubiquitinating enzymes in DNA double-strand break repair

Li, Y., & Yuan, J. (2021) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2000309 · Cited by 24 · see citing works

FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis

Li, Y., Chen, J., Wang, B., Xu, Z., Wu, C., Ma, J., Song, Q., Geng, Q., Yu, J., Pei, H., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100926 · Cited by 24 · see citing works

Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response

Garvin, A. J. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190534 · Cited by 22 · see citing works

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer

Martinez, S., Wu, S., Geuenich, M. J., Malik, A., Weber, R., Woo, T., Zhang, A. X. W., Jang, G. H., Dervovic, D., Al‐Zahrani, K. N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49450-3 · Cited by 29 · see citing works

Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma

Yao, X., Li, L., Piao, L., Zhang, G., Huang, X., Wang, Y., & Liang, Z.-L. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820967455 · Cited by 20 · see citing works

USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion

Tian, X., Zhao, Y., Yang, Z., Lu, Q., Zhou, L., & Zheng, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05277-8 · Cited by 20 · see citing works

USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis

Ren, Y., Song, Z., Rieser, J., Ackermann, J., Koch, I., Lv, X., Ji, T., & Cai, X. (2023) · Cancers · doi:10.3390/cancers15051371 · Cited by 20 · see citing works

USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

Han, S., Cui, L., Wang, B., Ruan, Y., Shi, M., Hong, C. S., Guan, X., Chen, Z., Li, Y., Liao, Y., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-1194 · Cited by 16 · see citing works

Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma

Mi, L., Cai, Y., Qi, J., Chen, L., Li, Y., Zhang, S., Ran, H., Qi, Q., Zhang, C., Wu, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60228-z · Cited by 19 · see citing works

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases

Bolhuis, D. L., Emanuele, M. J., & Brown, N. G. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230454 · Cited by 15 · see citing works

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

Zhang, Z., Wu, Y., Fu, J., Yu, X., Su, Y., Jia, S., Cheng, H., Shen, Y., He, X., Ren, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48173-9 · Cited by 14 · see citing works

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

Wang, Y., Liu, X., Zuo, X., Wang, C., Zhang, Z., Zhang, H., Zeng, T., Chen, S., Liu, M., Chen, H., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100550 · Cited by 14 · see citing works

N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma

Fang, R., Jia, Z., Xin, Y., Zhao, K., Qin, W., Lu, H., Zhou, Y., Yang, Y., & He, F. (2025) · Cell Death Discovery · doi:10.1038/s41420-024-02282-y · Cited by 14 · see citing works

Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery

Li, S., Zhang, H., & Wei, X. (2021) · Life · doi:10.3390/life11090965 · Cited by 13 · see citing works

Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies

Tang, J. Q., Marchand, M. M., & Veggiani, G. (2023) · Cells · doi:10.3390/cells12162117 · Cited by 11 · see citing works

Emerging strategies to overcome PARP inhibitors' resistance in ovarian cancer

Bi, R., Chen, L., Huang, M., Qiao, Z., Li, Z., Fan, G., & Wang, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189221 · Cited by 10 · see citing works

YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer

Zhao, T., Chen, X., Wu, J., Chen, S., Gan, Y., Liu, C., Ha, X., Wu, Y., Zhou, X. Y., Wu, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07886-5 · Cited by 10 · see citing works

Clinical application of PARP inhibitors and emerging strategies to overcome resistance: a pan-cancer perspective

Xiang, J., Li, J., Guo, Z., Wu, J., Ma, D., Xu, H., Shang, T., Pu, P., Cong, L., Zhou, R., et al. (2026) · Biomarker Research · doi:10.1186/s40364-026-00908-0 · Cited by 10 · see citing works

CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1

Deng, J., Zhang, T., Liu, F., Han, Q., Li, Q., Guo, X., Ma, Y., Li, L., & Shao, G. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.100 · Cited by 10 · see citing works

RNA methylation, homologous recombination repair and therapeutic resistance

Bai, Y., Zhao, H., Liu, H., Wang, W., Dong, H., & Zhao, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115409 · Cited by 10 · see citing works

Mechanisms of traditional Chinese medicine overcoming of radiotherapy resistance in breast cancer

Zhao, X., Luo, T., Qiu, Y., Yang, Z., Wang, D., Wang, Z., Zeng, J., & Bi, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1388750 · Cited by 9 · see citing works

DNA repair pathways in ovarian cancer: Implications for therapy and resistance

Miras, I., Gutiérrez, I. V., Estévez-García, P., & Muñoz-Galván, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118719 · Cited by 10 · see citing works

Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications

Zhang, Y., Li, Q., Lan, J., Xie, G., Zhang, G., Cui, J., Leng, P., & Wang, Y. (2025) · Carcinogenesis · doi:10.1093/carcin/bgaf006 · Cited by 9 · see citing works

Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors

Kroeger, C. M., Roesler, R., Wiese, S., Hainzl, A., & Gatzka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113762 · Cited by 9 · see citing works

Targeting the Wnt/β-catenin pathway and epithelial-mesenchymal transition in gastric cancer: mechanisms, therapeutic strategies, and clinical challenges

Shi, R., Cao, Z. A., Li, J., Ji, R., & Guo, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1633699 · Cited by 8 · see citing works

K48-linked deubiquitination of VGLL4 by USP15 enhances the efficacy of tumor immunotherapy in triple-negative breast cancer

Wang, X., Deng, X., Hu, J., Zheng, W., Ye, D., Zhou, X., & Fang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216764 · Cited by 8 · see citing works

Concurrent Preimplantation Genetic Testing and Competence Assessment of Human Embryos by Transcriptome Sequencing

Wang, Y., Li, Y., Zhu, X., Yang, M., Liu, Y., Wang, N., Long, C., Kuo, Y., Lian, Y., Huang, J. H., et al. (2024) · Advanced Science · doi:10.1002/advs.202309817 · Cited by 8 · see citing works

The Clinical Challenges, Trials, and Errors of Combatting Poly(ADP-Ribose) Polymerase Inhibitors Resistance

Pham, M. M., Hinchcliff, E., Avila, M., & Westin, S. N. (2021) · The Cancer Journal · doi:10.1097/ppo.0000000000000562 · Cited by 8 · see citing works

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cellsPreprint

van den Berk, P. C. M., Lancini, C., Serresi, M., Hulsman, D., Pritchard, C., Song, J., Schmitt, M. J., Tanger, E., Huijbers, I. J., Jacobs, H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.23.916627 · Cited by 8 · see citing works

The CYLD–PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells

Zheng, M., Wang, S., Tang, K., Kong, R., Wang, X., Zhou, J. Y., Chen, Y., & Wang, Y. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413890121 · Cited by 7 · see citing works

USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM

Zhu, R., Li, M., Wang, D., Liu, C., Xie, L., Yang, Y., Gu, X., Zhao, K., Tian, Y., & Cai, S. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00984-8 · Cited by 7 · see citing works

Multiplexed bioluminescence-mediated tracking of DNA double-strand break repairs in vitro and in vivo

Chien, J. C.-Y., Badr, C. E., & Lai, C. P. (2021) · Nature Protocols · doi:10.1038/s41596-021-00564-8 · Cited by 6 · see citing works

Myriad factors and pathways influencing tumor radiotherapy resistance

Mi, L., & Zhang, H. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0992 · Cited by 8 · see citing works

Decoding the key hallmarks of chemoresistance: A proteomic tale from breast cancer research

Bhavsar, P. P., Kalita, B., Taunk, K., & Rapole, S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189404 · Cited by 6 · see citing works

ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancer

Huang, S., Qiu, Y., Wu, L., Xie, Y., He, Z., Li, Y.-Q., & Xie, X. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.038 · Cited by 6 · see citing works

SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection

Fu, H., Huang, M., Wu, H., Zheng, H., Gong, Y., Xing, L., Gong, J., An, R., Li, Q., Jie, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57599-8 · Cited by 6 · see citing works

Characterization of SHCBP1 to prognosis and immunological landscape in pan-cancer: novel insights to biomarker and therapeutic targets

Jiang, F., Shi, Y., Wang, Y., Ge, C., Zhu, J., Fang, H., Zhang, Y. X., Zhang, Y., Jian, H., Lei, T., et al. (2023) · Aging · doi:10.18632/aging.204591 · Cited by 6 · see citing works

USP25 inhibits DNA damage by stabilizing BARD1 protein in a house dust mite‐induced asthmatic model in vitro and in vivo

Gan, C., Wang, Y., Zhao, Q. L., Kong, M., Chen, J., Zhang, W., Tan, L., & Tian, M. (2022) · Cell Biology International · doi:10.1002/cbin.11775 · Cited by 6 · see citing works

Assessing the suitability of deubiquitylases as substrates for targeted protein degradation

Tong, J., Watkins, J. M., Burke, J. M., & Kodadek, T. J. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.03.009 · Cited by 6 · see citing works

A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis

Ling, J., Qin, C., Li, T., Wang, B., Cai, W., Ma, L., Wang, Y., Chen, J., & Xu, F. (2022) · Journal of Oncology · doi:10.1155/2022/1427726 · Cited by 5 · see citing works

Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors

Wang, C., Tian, L., He, Q., Lin, S., Wu, Y., Qiao, Y., Zhu, B., Li, D., & Chen, G. (2023) · Oncogene · doi:10.1038/s41388-023-02812-5 · Cited by 5 · see citing works

Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma

Jiang, Y., Ji, D., Chen, W., Zhu, Y., Luo, M. B., Zou, R., Fu, Y., Huang, P., Shi, Q., Wang, D., et al. (2025) · Oncogene · doi:10.1038/s41388-024-03263-2 · Cited by 4 · see citing works

Molecular regulation by ubiquitin-specific proteases (USPs) in HCC: cell cycle, oncogenic signaling, and beyond

Al-Khateeb, F. N., YOUSIF, A. Y., Al‐Shawi, S. G., Alkhathami, A. G., Roopashree, R., Kashyap, A., Nathiya, D., Ray, S., Alnajar, M. J., & Kareem, M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04395-2 · Cited by 4 · see citing works

USP15 Drives NSCLC Progression and Chemoresistance, Potentially via Regulation of the U2 ‐Type Spliceosomal Complex

Chiu, C., Hsu, S., Liu, W., Lin, I., Qiu, W., Hsieh, C., & Chou, C. (2025) · Cancer Medicine · doi:10.1002/cam4.71055 · Cited by 4 · see citing works

Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stability

Vue, Y., Mullon, P. J., Leehangin, A., Maldonado-Luevano, E., Hasselmann, T. D., Mehta, K. P. M., & Mohni, K. N. (2025) · Journal of Virology · doi:10.1128/jvi.00893-25 · Cited by 4 · see citing works

PARP inhibitors for HRR-deficient metastatic castration-resistant prostate cancer: mechanisms and clinical strategies

Peng, N., Chen, D., Yang, M., Zeng, C., & Li, W. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107193 · Cited by 5 · see citing works

Transcription Factors, R-Loops and Deubiquitinating Enzymes: Emerging Targets in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Barabino, S. M. L., Citterio, E., & Ronchi, A. E. (2021) · Cancers · doi:10.3390/cancers13153753 · Cited by 4 · see citing works

Deubiquitinating enzymes at the crossroads of blood–brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions

Munavar-K, F., & Lenka, N. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2504738 · Cited by 5 · see citing works

Understanding DNA and PARP in Cancer: Tackling Inhibitor Resistance

Balachandran, H., Byran, G., Karri, V. V. S. R., Murugesan, S. K., & Rajagopal, K. (2025) · Drug Metabolism and Bioanalysis Letters · doi:10.2174/0118723128343916250212094926 · Cited by 3 · see citing works

Deubiquitinating Enzymes in Model Systems and Therapy: Redundancy and Compensation Have Implications

Zachariah, S., & Gray, D. A. (2019) · BioEssays · doi:10.1002/bies.201900112 · Cited by 3 · see citing works

NASP Promotes Triple-negative Breast Cancer Progression and Metastasis by Stabilizing YAP in a USP15-Dependent Way

Zheng, W., Luo, Q., Wang, X., Zhou, X., Ye, D., Hua, K., & Fang, L. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.99438 · Cited by 2 · see citing works

Research progress on the association between environmental pollutants and the resistance mechanism of PARP inhibitors in ovarian cancer

Zhou, L., Xiang, J., & He, Y. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15852-9 · Cited by 2 · see citing works

Phosphorylation of RNF213 by ATM-mediated ubiquitination of RPA1 regulates homologous recombination repair and chemosensitivity

Hu, D., Wu, W., Wu, C., Li, J., Ruan, B., Cheng, H., Jiang, Y., Wang, Y., & Song, Z. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08041-w · Cited by 2 · see citing works

Deubiquitinases in DNA damage repair: Implication and mechanism in cancer

Li, L., Gu, X., & Zhang, T. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152914 · Cited by 1 · see citing works

Targeting deubiquitinating enzymes in cancer: navigating context-dependence for precision medicine

Khamjan, N. A. (2025) · ONCOLOGIE · doi:10.1515/oncologie-2025-0359 · Cited by 1 · see citing works

Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway

Zhong, M., Zhou, L., Fang, Z., Yao, Y., Zou, J.-P., Xiong, J., Xiang, X., & Deng, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i26.4216

Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer

Gubat, J. (2024) · Linköping University medical dissertations · doi:10.3384/9789180755610

USP15-Driven De-Ubiquitination of FIS1, Impairing Mitochondrial Function, Enhances The Radiotherapy Sensitivity of Bladder Cancer CellsPreprint

Xiong, R., Wang, M., Du, J., Han, J., Liu, C., Yao, Y., Wang, B., Li, S.-J., Yao, Y., & Liu, R. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5025906

KIF20A Facilitates Prostate Cancer Proliferation and Docetaxel Resistance via Enhancing USP15-Dependent K63-linked deubiquitination of G3BP1Preprint

Xu, A., Guo, K., Gao, Z., Chen, Q., Tang, Z., Deng, Y., Fang, Z., Huang, R., & Chen, B. S. (2026) · Research Square · doi:10.21203/rs.3.rs-8788398/v1

USP15 Promotes Pancreatic Cancer Progression and Cisplatin Resistance By Activating DNA Damage Repair

Ma, Z., Li, H., Zeng, G., Jiao, G., Han, S., Ruan, Y., Lan, Y., Guan, X., Song, Y., Liu, C., et al. (2026) · Molecular Carcinogenesis · doi:10.1002/mc.70105

USP15 regulates TRIM21/GSDMD pathway to affect lipopolysaccharide-induced acute liver injury

Wang, X., Wang, Y., Guo, S., Tian, X., Zhuang, C., Ning, S., Gao, D., Wang, Z., Zhao, Y., & Yao, J. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116804

Ubiquitin-specific proteases in ovarian cancer: molecular mechanisms and therapeutic implications

Deng, L., Jiang, Y., Wang, D., Yu, J., & Wu, L. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02138-2

USP15-mediated deubiquitination of FIS1 impairs mitochondrial function and sensitizes bladder cancer cells to radiotherapy

Xiong, R., Ml, W., Du, J., Chai, B., Zhou, Q., Yan, Y., Han, J., Yao, Y., Liu, C., Yang, J., et al. (2026) · Oncogene · doi:10.1038/s41388-026-03918-2

USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity

Nespolo, A., Stefenatti, L., Pellarin, I., Gambelli, A., Vinciguerra, G. L. R., Karimbayli, J., Barozzi, S., Orsenigo, F., Spizzo, R., Nicoloso, M. S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp6567 · Cited by 26 · see citing works

Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair

Wiltshire, T. D., Lovejoy, C. A., Wang, T., Xia, F., O’Connor, M. J., & Cortez, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.104745 · Cited by 120 · see citing works

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

Clements, K. E., Schleicher, E. M., Thakar, T., Hale, A., Dhoonmoon, A., Tolman, N. J., Sharma, A., Liang, X., Kawasawa, Y. I., Nicolae, C. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19961-w · Cited by 55 · see citing works

USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells

Lu, Q., Zhang, F.-L., Lu, D., Shao, Z., & Li, D. (2019) · Cancer Medicine · doi:10.1002/cam4.2528 · Cited by 43 · see citing works

KSQ-4279, a first-in-class USP1 inhibitor shows strong combination activity in BRCA mutant cancers with intrinsic or acquired resistance to PARP inhibitors

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