CCDC98 targets BRCA1 to DNA damage sites

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

BRCA1 and BRCA2: 1994 and beyond

Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967 · see citing works

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

Yoshida, K., & Miki, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02195.x · Cited by 753 · see citing works

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743 · see citing works

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Sobhian, B., Shao, G., Lilli, D. R., Culhane, A. C., Moreau, L. A., Xia, B., Livingston, D. M., & Greenberg, R. A. (2007) · Science · doi:10.1126/science.1139516 · Cited by 672 · see citing works

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

Manke, I. A., Lowery, D. M., Nguyen, A., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1088877 · Cited by 651 · see citing works

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

Kim, H., Chen, J., & Yu, X. (2007) · Science · doi:10.1126/science.1139621 · Cited by 540 · see citing works

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

Brzović, P. S., Rajagopal, P., Hoyt, D. W., King, M., & Klevit, R. E. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-833 · Cited by 494 · see citing works

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389 · see citing works

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359 · see citing works

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

Li, S., Ting, N. S. Y., Zheng, L., Chen, P., Ziv, Y., Shiloh, Y., Lee, E. Y.-H. P., & Lee, W. (2000) · Nature · doi:10.1038/35018134 · Cited by 336 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

Wu-Baer, F., Lagrazon, K., Yuan, W., & Baer, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300249200 · Cited by 302 · see citing works

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei, M. H., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. L., & Khanna, K. K. (2000) · PubMed · Cited by 247 · see citing works

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Clapperton, J. A., Manke, I. A., Lowery, D. M., Ho, T., Haire, L. F., Yaffe, M. B., & Smerdon, S. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb775 · Cited by 243 · see citing works

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains

Rodriguez, M., Yu, X., Chen, J., & Songyang, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300407200 · Cited by 234 · see citing works

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

Starita, L. M. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00042-5 · Cited by 234 · see citing works

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

Williams, R. S., Lee, M. S., Hau, D. D., & Glover, J. N. M. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb776 · Cited by 230 · see citing works

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

Chen, A., Kleiman, F. E., Manley, J. L., Ouchi, T., & Pan, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201252200 · Cited by 218 · see citing works

Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein

Xia, Y., Pao, G. M., Chen, H.-W., Verma, I. M., & Hunter, T. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m204591200 · Cited by 195 · see citing works

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

Li, S., Chen, P., Subramanian, T., Chinnadurai, G., Tomlinson, G. E., Osborne, C. K., Sharp, Z. D., & Lee, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11334 · Cited by 192 · see citing works

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 189 · see citing works

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00238-2 · Cited by 174 · see citing works

Characterization of a carboxy-terminal BRCA1 interacting protein

Wong, A. K. C., Ormonde, P. A., Pero, R. S., Chen, Y., Lian, L., Salada, G. C., Berry, S., Lawrence, Q. A., Dayananth, P., Ha, P. C., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202150 · Cited by 162 · see citing works

Structural Basis of BACH1 Phosphopeptide Recognition by BRCA1 Tandem BRCT Domains

Botuyan, M. V., Nominé, Y., Yu, X., Juranić, N., Macura, S. I., Chen, J., & Mer, G. (2004) · Structure · doi:10.1016/j.str.2004.06.002 · Cited by 97 · see citing works

The DNA double-strand break response pathway: becoming more BRCAish than ever

Ting, N. S. Y., & Lee, W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.026 · Cited by 66 · see citing works

BRCA1 and Chk1 in G2/M Checkpoint: A New Order of Regulation

Lee, E. Y.-H. P. (2002) · Cell Cycle · doi:10.4161/cc.1.3.121 · Cited by 12 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works

The role of BRCA1 in DNA damage response

Wu, J., Lu, L.-Y., & Yu, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0010-5 · Cited by 235 · see citing works

The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

Peng, Y., Liao, Q., Tan, W., Peng, C., Hu, Z., Chen, Y., Li, Z., Li, J., Zhen, B., Zhu, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09232-8 · Cited by 104 · see citing works

BRCA1 tumor suppressor network: focusing on its tail

Wang, B. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-6 · Cited by 78 · see citing works

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

Nikkilä, J., Coleman, K. A., Morrissey, D., Pylkäs, K., Erkko, H., Messick, T. E., Karppinen, S.-M., Amelina, A., Winqvist, R., & Greenberg, R. A. (2009) · Oncogene · doi:10.1038/onc.2009.33 · Cited by 63 · see citing works

Breast Cancer–Associated <i>Abraxas</i> Mutation Disrupts Nuclear Localization and DNA Damage Response Functions

Solyom, S., Aressy, B., Pylkäs, K., Patterson-Fortin, J., Hartikainen, J. M., Kallioniemi, A., Kauppila, S., Nikkilä, J., Kosma, V.-M., Mannermaa, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003223 · Cited by 59 · see citing works

The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

Castillo, A., Paul, A., Sun, B., Huang, T. H., Wang, Y., Yazinski, S. A., Tyler, J., Li, L., You, M. J., Zou, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.050 · Cited by 39 · see citing works

RAP80 regulates epithelial–mesenchymal transition related with metastasis and malignancy of cancer

Park, S. Y., Korm, S., Chung, H. J., Choi, S. J., Jang, J., Cho, S., Lim, Y. T., Kim, H., & Lee, J. (2016) · Cancer Science · doi:10.1111/cas.12877 · Cited by 12 · see citing works

DNA damage checkpoint maintenance through sustained Chk1 activity

Latif, C., den Elzen, N. R., & O’Connell, M. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01204 · Cited by 49 · see citing works

Resisting Arrest: Recovery from Checkpoint Arrest Through Dephosphorylation of Chk1 by PP1

den Elzen, N. R., Kosoy, A., Christopoulos, H., & O’Connell, M. J. (2004) · Cell Cycle · doi:10.4161/cc.3.5.820 · Cited by 25 · see citing works

Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1

den Elzen, N. R., & O'Connell, M. J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600105 · Cited by 102 · see citing works

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

Willis, J., DeStephanis, D., Patel, Y. K., Gowda, V., & Yan, S. (2012) · Journal of Visualized Experiments · doi:10.3791/4449-v · Cited by 1 · see citing works

Establishment of and Recovery from Damage Checkpoint Requires Sequential Interactions of Crb2 with Protein Kinases Rad3, Chk1, and Cdc2Preprint

Esashi, F., Mochida, S., Matsusaka, T., OBARA, T., OGAWA, A., Tamai, K., & Yanagida, M. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.443 · Cited by 8 · see citing works