A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
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Cells maintain the balance between homeostasis and inflammation by adapting and integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway. Our understanding of how a tailored switch from homeostasis to a strong receptor-dependent response is coordinated remains limited. Here, we use an integrated transcriptomic and proteomic approach to analyze transcription-factor binding, gene expression and in vivo proximity-dependent labelling of proteins in living cells under homeostatic and interferon (IFN)-induced conditions. We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3. Whereas preformed STAT2-IRF9 complexes control basal expression of IFN-induced genes (ISG), both type I IFN and IFN-γ cause promoter binding of a complete ISGF3 complex containing STAT1, STAT2 and IRF9. In contrast to the dogmatic view of ISGF3 formation in the cytoplasm, our results suggest a model wherein the assembly of the ISGF3 complex occurs on DNA.
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The wider footprints correspond to ISGF3 trimer binding and are consistent with the known structure and DNA contacts of ISGF3 and its subunits.
“Together, these findings imply that the wider footprints (due to increased steric blockage of methylation at ISREs) correspond to ISGF3 trimer binding and are consistent with the known structure and DNA contacts of ISGF3 and its subunits40,41”
From Single-molecule states link transcription factor binding to gene expression (2024) · cites this paper as [41]
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668 · see citing works
The Perseus computational platform for comprehensive analysis of (prote)omics data
Tyanova, S., Temu, T., Sinitcyn, P. G., Carlson, A., Hein, M. Y., Geiger, T., Mann, M., & Cox, J. (2016) · Nature Methods · doi:10.1038/nmeth.3901 · Cited by 7,977 · see citing works
Li, H. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr509 · Cited by 6,283 · see citing works
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
Cox, J., Hein, M. Y., Luber, C. A., Paron, I., Nagaraj, N., & Mann, M. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.031591 · Cited by 5,180 · see citing works
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
MacLean, B., Tomazela, D. M., Shulman, N., Chambers, M., Finney, G. L., Frewen, B., Kern, R., Tabb, D. L., Liebler, D. C., & MacCoss, M. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq054 · Cited by 4,697 · see citing works
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
Tyanova, S., Temu, T., & Cox, J. (2016) · Nature Protocols · doi:10.1038/nprot.2016.136 · Cited by 4,691 · see citing works
Rappsilber, J., Mann, M., & Ishihama, Y. (2007) · Nature Protocols · doi:10.1038/nprot.2007.261 · Cited by 4,641 · see citing works
Differential analysis of gene regulation at transcript resolution with RNA-seq
Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492 · see citing works
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,311 · see citing works
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780 · see citing works
ProteomeXchange provides globally coordinated proteomics data submission and dissemination
Vizcaíno, J. A., Deutsch, E. W., Wang, R., Csordás, A., Reisinger, F., Ríos, D., Dianes, J. A., Sun, Z., Farrah, T., Bandeira, N., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2839 · Cited by 2,735 · see citing works
Roux, K. J., Kim, D. I., Raida, M., & Burke, B. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112098 · Cited by 2,416 · see citing works
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works
IFNα activates dormant haematopoietic stem cells in vivo
Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368 · see citing works
Peterson, A. C., Russell, J. D., Bailey, D. J., Westphall, M. S., & Coon, J. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o112.020131 · Cited by 1,288 · see citing works
JAK-STAT Signaling: From Interferons to Cytokines
Schindler, C., Levy, D. E., & Decker, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700016200 · Cited by 1,263 · see citing works
Self-citationDesign and analysis of ChIP-seq experiments for DNA-binding proteins
Kharchenko, P., Tolstorukov, M., & Park, P. J. (2008) · Nature Biotechnology · doi:10.1038/nbt.1508 · Cited by 950 · see citing works
Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA
Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J. E., Jr., & Kuriyan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81443-9 · Cited by 723 · see citing works
Interferon-inducible effector mechanisms in cell-autonomous immunity
MacMicking, J. D. (2012) · Nature reviews. Immunology · doi:10.1038/nri3210 · Cited by 564 · see citing works
Probing nuclear pore complex architecture with proximity-dependent biotinylation
Kim, D. I., KC, B., Zhu, W., Motamedchaboki, K., Doye, V., & Roux, K. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406459111 · Cited by 560 · see citing works
Levy, D. E., Kessler, D. S., Pine, R. I., Reich, N. C., & Darnell, J. E., Jr. (1988) · Genes & Development · doi:10.1101/gad.2.4.383 · Cited by 559 · see citing works
BioID: A Screen for Protein‐Protein Interactions
Roux, K. J., Kim, D. I., & Burke, B. E. (2013) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps1923s74 · Cited by 505 · see citing works
A weak signal for strong responses: interferon-alpha/beta revisited
Taniguchi, T., & Takaoka, A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073080 · Cited by 483 · see citing works
Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling
Gough, D. J., Messina, N. L., Clarke, C. J. P., Johnstone, R. W., & Levy, D. E. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.011 · Cited by 472 · see citing works
Immune Response in Stat2 Knockout Mice
Park, C. Y., Li, S. C., Cha, E., & Schindler, C. (2000) · Immunity · doi:10.1016/s1074-7613(00)00077-7 · Cited by 415 · see citing works
Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., & Ohteki, T. (2009) · Nature Medicine · doi:10.1038/nm.1973 · Cited by 412 · see citing works
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
Wu, X., Thi, V. L. D., Huang, Y., Billerbeck, E., Saha, D., Hoffmann, H.-H., Wang, Y., Silva, L. A. V., Sarbanes, S. L., Sun, T., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.018 · Cited by 385 · see citing works
Parsing the interferon transcriptional network and its disease associations
Mostafavi, S., Yoshida, H., Moodley, D., LeBoité, H., Rothamel, K., Raj, T., Ye, C. J., Chevrier, N., Zhang, S.-Y., Feng, T., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.032 · Cited by 337 · see citing works
BioID: A Screen for Protein‐Protein Interactions
Roux, K. J., Kim, D. I., Burke, B. E., & May, D. G. (2018) · Current Protocols in Protein Science · doi:10.1002/cpps.51 · Cited by 334 · see citing works
IFNβ‐dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
Cheon, H., Holvey-Bates, E. G., Schoggins, J. W., Forster, S. C., Hertzog, P. J., Imanaka, N., Rice, C. M., Jackson, M. W., Junk, D. J., & Stark, G. R. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.203 · Cited by 332 · see citing works
Majoros, A., Platanitis, E., Kernbauer, E., Rosebrock, F., Müller, M. M., & Decker, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00029 · Cited by 321 · see citing works
Self-citationKessler, D. S., Veals, S. A., Fu, X. Y., & Levy, D. E. (1990) · Genes & Development · doi:10.1101/gad.4.10.1753 · Cited by 312 · see citing works
Role of STAT3 in Type I Interferon Responses
Ho, H. H., & Ivashkiv, L. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511797200 · Cited by 302 · see citing works
Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
Au-Yeung, N., Mandhana, R., & Horvath, C. M. (2013) · JAK-STAT · doi:10.4161/jkst.23931 · Cited by 291 · see citing works
Mutational switch of an IL-6 response to an interferon-γ-like response
Costa‐Pereira, A. P., Tininini, S., Strobl, B., Alonzi, T., Schlaak, J., Is’harc, H., Gesualdo, I., Newman, S. J., Kerr, I. M., & Poli, V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122236099 · Cited by 264 · see citing works
Panorama Public: A Public Repository for Quantitative Data Sets Processed in Skyline
Sharma, V., Eckels, J., Schilling, B., Ludwig, C., Jaffe, J. D., MacCoss, M. J., & MacLean, B. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000543 · Cited by 263 · see citing works
Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
Platanitis, E., & Decker, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02542 · Cited by 251 · see citing works
Self-citationNovel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-β In Vivo
Lienenklaus, S., Cornitescu, M., Ziętara, N., Łyszkiewicz, M., Gekara, N. O., Jabłońska, J., Edenhofer, F., Rajewsky, K., Bruder, D., Hafner, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804277 · Cited by 238 · see citing works
Qureshi, S. A., Salditt-Georgieff, M., & Darnell, J. E., Jr. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3829 · Cited by 235 · see citing works
Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R. S., Takasugi, T., Matsuyama, T., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.08008.x · Cited by 233 · see citing works
Kessler, D. S., Levy, D. E., & Darnell, J. E., Jr. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8521 · Cited by 232 · see citing works
Cai, Y., Jin, J., Tomomori‐Sato, C., Sato, S., Sorokina, I., Parmely, T. J., Conaway, R. C., & Conaway, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300389200 · Cited by 224 · see citing works
Cuartero, S., Weiss, F. D., Dharmalingam, G., Guo, Y., Ing-Simmons, E., Masella, S., Robles-Rebollo, I., Xiao, X., Wang, Y.-F., Barozzi, I., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0184-1 · Cited by 210 · see citing works
Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1
Gough, D. J., Messina, N. L., Hii, L. L., Gould, J. A., Sabapathy, K., Robertson, A. P. S., Trapani, J. A., Levy, D. E., Hertzog, P. J., Clarke, C. J. P., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000361 · Cited by 193 · see citing works
Majumder, S., Zhou, L. Z.-H., Chaturvedi, P., Babcock, G., Aras, S., & Ransohoff, R. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4736 · Cited by 181 · see citing works
Stancato, L. F., David, M., Carter‐Su, C., Larner, A. C., & Pratt, W. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4134 · Cited by 181 · see citing works
Majumder, S., Zhou, L., Chaturvedi, P., Babcock, G., Aras, S., & Ransohoff, R. M. (1998) · PubMed · Cited by 171 · see citing works
Toward a new STATe: The role of STATs in mitochondrial function
Meier, J. A., & Larner, A. C. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2013.12.005 · Cited by 168 · see citing works
Mertens, C., Zhong, M., Krishnaraj, R., Zou, W., Chen, X., & Darnell, J. E., Jr. (2006) · Genes & Development · doi:10.1101/gad.1485406 · Cited by 164 · see citing works
Bluyssen, H. R., & Levy, D. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4600 · Cited by 150 · see citing works
The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses.
Błaszczyk, K., Nowicka, H., Kostyrko, K., Antonczyk, A., Wesoły, J., & Bluyssen, H. (2016) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2016.02.010 · Cited by 147 · see citing works
EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation
Pradhan, S. K., Su, T., Yen, L., Jacquet, K., Huang, C., Côté, J., Kurdistani, S. K., & Carey, M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.039 · Cited by 141 · see citing works
Martinez-Moczygemba, M., Gutch, M. J., French, D. L., & Reich, N. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20070 · Cited by 135 · see citing works
Interferon messenger RNA is produced constitutively in the organs of normal individuals.
Tovey, M. G., Streuli, M., Gresser, I., Gugenheim, J., Blanchard, B., Guymarho, J., Vignaux, F., & Gigou, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.5038 · Cited by 133 · see citing works
Banninger, G. P., & Reich, N. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400815200 · Cited by 127 · see citing works
Fink, K., & Grandvaux, N. (2013) · JAK-STAT · doi:10.4161/jkst.27521 · Cited by 122 · see citing works
Lau, J. F., Parisien, J.-P., & Horvath, C. M. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.13.7278 · Cited by 120 · see citing works
Kraus, T., Lau, J. F., Parisien, J.-P., & Horvath, C. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212972200 · Cited by 109 · see citing works
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression
Jing, N., Wang, Y., Yang, J. B., & Stark, G. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714102115 · Cited by 109 · see citing works
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA
Diner, B. A., Li, T., Greco, T. M., Crow, M. S., Fuesler, J., Wang, J. P., & Cristea, I. M. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145808 · Cited by 92 · see citing works
Apical role for BRG1 in cytokine-induced promoter assembly
Ni, Z., Karaskov, E., Yu, T., Callaghan, S. M., Der, S., Park, D. S., Xu, Z., Pattenden, S. G., & Bremner, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503070102 · Cited by 92 · see citing works
Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function
Rengachari, S., Groiss, S., Devos, J. M., Caron, E., Grandvaux, N., & Panne, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718426115 · Cited by 91 · see citing works
PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN–Inducible Proteins
Caprara, G., Prosperini, E., Piccolo, V., Sigismondo, G., Melacarne, A., Cuomo, A., Boothby, M. R., Rescigno, M., Bonaldi, T., & Natoli, G. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701117 · Cited by 83 · see citing works
Wang, W., Yin, Y., Xu, L., Su, J., Huang, F., Wang, Y., Boor, P. P. C., Chen, K., Wang, W., Cao, W., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aah4248 · Cited by 78 · see citing works
Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons
Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Kenner, L., Müller, M. M., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01498-14 · Cited by 66 · see citing works
Self-citationHo, J., Pelzel, C., Begitt, A., Mee, M., Elsheikha, H. M., Scott, D. J., & Vinkemeier, U. (2016) · PLoS Biology · doi:10.1371/journal.pbio.2000117 · Cited by 63 · see citing works
Delgoffe, G. M., & Vignali, D. (2013) · JAK-STAT · doi:10.4161/jkst.23060 · Cited by 62 · see citing works
Testoni, B., Voellenkle, C., Guerrieri, F., Gerbal‐Chaloin, S., Blandino, G., & Levrero, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.231068 · Cited by 59 · see citing works
Majoros, A., Platanitis, E., Szappanos, D., Cheon, H., Vogl, C., Shukla, P., Stark, G. R., Sexl, V., Schreiber, R. D., Schindler, C., et al. (2016) · EMBO Reports · doi:10.15252/embr.201540726 · Cited by 55 · see citing works
Self-citationSisler, J. D., Morgan, M., Raje, V., Grande, R. C., Derecka, M., Meier, J. A., Cantwell, M. T., Szczepanek, K., Korzun, W. J., Lesnefsky, E. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144444 · Cited by 45 · see citing works
Au-Yeung, N., & Horvath, C. M. (2018) · iScience · doi:10.1016/j.isci.2018.07.013 · Cited by 42 · see citing works
Normal human epidermis contains an interferon-like protein.
Yaar, M., Palleroni, A. V., & Gilchrest, B. A. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.4.1349 · Cited by 33 · see citing works
The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes
Gnatovskiy, L., Mita, P., & Levy, D. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01562-12 · Cited by 32 · see citing works
Promoter Occupancy of STAT1 in Interferon Responses Is Regulated by Processive Transcription
Wiesauer, I., Gaumannmüller, C., Steinparzer, I., Strobl, B., & Kovarik, P. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01097-14 · Cited by 16 · see citing works
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Research works printed but not linked: 1
- [55]Mariani, M. et al. RNASeq analysis identifies non-canonical role of STAT2 and IRF9 in the regulation of a STAT1-independent antiviral and immunoregulatory transcriptional program induced by IFNβ and TNFα. Preprint at https://www.biorxiv.org/content/10.1101/273623v1 (2018). · DOI
Cited by
Sorted by citations
The JAK-STAT pathway at 30: Much learned, much more to do
Philips, R. L., Wang, Y., Cheon, H., Kanno, Y., Gadina, M., Sartorelli, V., Horvath, C. M., Darnell, J. E., Jr., Stark, G. R., & O’Shea, J. J. (2022) · Cell · doi:10.1016/j.cell.2022.09.023 · Cited by 740 · see citing works
Type I interferon-mediated tumor immunity and its role in immunotherapy
Yu, R., Zhu, B., & Chen, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04219-z · Cited by 309 · see citing works
Neutrophil diversity and function in health and disease
Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 284 · see citing works
Innate immune evasion strategies of SARS-CoV-2
Minkoff, J. M., & tenOever, B. R. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00839-1 · Cited by 255 · see citing works
Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
Platanitis, E., & Decker, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02542 · Cited by 251 · see citing works
Self-citationTime-resolved single-cell transcriptomics defines immune trajectories in glioblastoma
Kirschenbaum, D. S., Xie, K., Ingelfinger, F., Katzenelenbogen, Y., Abadie, K., Look, T., Sheban, F., Phan, T. S., Li, B., Zwicky, P., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.032 · Cited by 217 · see citing works
Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0620 · Cited by 182 · see citing works
Zimmerli, D., Brambillasca, C. S., Talens, F., Bhin, J., Linstra, R., Romanens, L., Bhattacharya, A., Joosten, S. E. P., Silva, A. M. D., Padrão, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34000-6 · Cited by 153 · see citing works
Regulation of IRF3 activation in human antiviral signaling pathways
Hamrashdi, M. A., & Brady, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115026 · Cited by 137 · see citing works
Lopez, J., Mommert, M., Mouton, W., Pizzorno, A., Brengel‐Pesce, K., Mezidi, M., Villard, M., Lina, B., Richard, J., Fassier, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211211 · Cited by 120 · see citing works
JAK-STAT signaling maintains homeostasis in T cells and macrophages
Fortelny, N., Farlik, M., Fife, V. E. R., Gorki, A.-D., Lassnig, C., Maurer, B., Meissl, K., Dolezal, M., Boccuni, L., Geetha, A. R. S. J., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01804-1 · Cited by 111 · see citing works
Self-citationInterferons in health and disease
Boehmer, D. F. R., & Zanoni, I. (2025) · Cell · doi:10.1016/j.cell.2025.06.044 · Cited by 101 · see citing works
The regulatory landscape of macrophage interferon signaling in inflammation
Siebeler, R., de Winther, M. P. J., & Hoeksema, M. A. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.04.022 · Cited by 91 · see citing works
Abnormalities of the type I interferon signaling pathway in lupus autoimmunity
Gallucci, S., Meka, S., & Gamero, A. M. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155633 · Cited by 83 · see citing works
Transcriptional and chromatin regulation in interferon and innate antiviral gene expression
Au-Yeung, N., & Horvath, C. M. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.003 · Cited by 74 · see citing works
Structural basis for STAT2 suppression by flavivirus NS5
Wang, B., Thurmond, S., Zhou, K., Sánchez-Aparicio, M. T., Fang, J., Lu, J., Gao, L., Ren, W., Cui, Y., Veit, E. C., et al. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0472-y · Cited by 70 · see citing works
JAK/STAT pathway in pathology of rheumatoid arthritis (Review)
Ciobanu, D. A., Poenariu, I. S., Cr�nguș, L.-I., Vreju, F. A., Turcu-Ştiolică, A., Tica, A. A., Pădureanu, V., Dumitraşcu, R. M., Bănicioiu-Covei, S., Dinescu, Ș. C., et al. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8982 · Cited by 69 · see citing works
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
Song, Q., Fan, Y., Zhang, H., & Wang, N. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.03.005 · Cited by 67 · see citing works
SARS-CoV-2 Non-Structural Proteins and Their Roles in Host Immune Evasion
Low, Z. Y., Zabidi, N. Z., Yip, A. J. W., Puniyamurti, A., Chow, V. T. K., & Lal, S. K. (2022) · Viruses · doi:10.3390/v14091991 · Cited by 63 · see citing works
Altered increase in STAT1 expression and phosphorylation in severe COVID‐19
Rincón-Arévalo, H., Aue, A., Ritter, J., Szelinski, F., Khadzhynov, D., Zickler, D., Stefanski, A., Lino, A. C., Körper, S., Eckardt, K., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202149575 · Cited by 61 · see citing works
Kanno, T., Nakajima, T., Yokoyama, S., Asou, H. K., Sasamoto, S., Kamii, Y., Hayashizaki, K., Ouchi, Y., Onodera, T., Takahashi, Y., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02310-y · Cited by 56 · see citing works
Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency
Gothe, F., Spegarova, J. S., Hatton, C. F., Griffin, H. R., Sargent, T., Cowley, S. A., James, W., Roppelt, A., Shcherbina, A. Y., Hauck, F. H., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.01.026 · Cited by 55 · see citing works
Guo, C., Wu, M., Huang, B., Zhao, R., Jin, L., Fu, B., Wang, P., Wang, D., Zheng, M., Fang, J., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01049-3 · Cited by 54 · see citing works
Ahmed, N. S., Gatchalian, J., Ho, J., Burns, M. J., Hah, N., Wei, Z., Downes, M., Evans, R. M., & Hargreaves, D. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110812119 · Cited by 49 · see citing works
Csumita, M., Csermely, A., Horváth, A., Nagy, G., Monori, F., Göczi, L., Orbea, H. A., Reith, W., & Széles, L. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1112 · Cited by 48 · see citing works
Duncan, C. J. A., & Hambleton, S. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01118-z · Cited by 48 · see citing works
Conde, J. N., Schutt, W. R., Mladinich, M. C., Sohn, S., Hearing, P., & Mackow, E. R. (2020) · Journal of Virology · doi:10.1128/jvi.01086-20 · Cited by 46 · see citing works
Interferons reshape the 3D conformation and accessibility of macrophage chromatin
Platanitis, E., Gruener, S., Geetha, A. R. S. J., Boccuni, L., Vogt, A., Novatchkova, M., Sommer, A., Barozzi, I., Müller, M. M., & Decker, T. (2022) · iScience · doi:10.1016/j.isci.2022.103840 · Cited by 45 · see citing works
Self-citationCutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway
Fischer, K., Tschismarov, R., Pilz, A., Straubinger, S., Carotta, S., McDowell, A., & Decker, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571334 · Cited by 44 · see citing works
Self-citationThe Yin and Yang of Type I IFNs in Cancer Promotion and Immune Activation
Musella, M., Galassi, C., Manduca, N., & Sistigu, A. (2021) · Biology · doi:10.3390/biology10090856 · Cited by 45 · see citing works
Huang, Z., Cao, H., Zeng, F., Lin, S., Chen, J., Luo, Y. M., You, J., Kong, C., Mai, Z., Deng, J., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01977-22 · Cited by 43 · see citing works
Single-molecule states link transcription factor binding to gene expression
Doughty, B. R., Hinks, M. M., Schaepe, J. M., Marinov, G. K., Thurm, A. R., Rios-Martinez, C., Parks, B. E., Tan, Y., Marklund, E., Dubocanin, D., et al. (2024) · Nature · doi:10.1038/s41586-024-08219-w · Cited by 42 · see citing works
Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense
Tong, Z., Zou, J., Wang, S., Luo, W., & Wang, Y. (2024) · Advanced Science · doi:10.1002/advs.202308890 · Cited by 42 · see citing works
Swaraj, S., & Tripathi, S. (2024) · mBio · doi:10.1128/mbio.02582-24 · Cited by 41 · see citing works
Winkle, J. A. V., Constant, D. A., Li, L., & Nice, T. J. (2020) · Journal of Virology · doi:10.1128/jvi.00603-20 · Cited by 39 · see citing works
Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics
Schwartz, M., Shnayder, M., Nachshon, A., Arazi, T., Kitsberg, Y., Samia, R. L., Lavi, M., Kuint, R., Tsabari, R., & Stern‐Ginossar, N. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01325-x · Cited by 38 · see citing works
Zheng, Q., Wang, D., Lin, R., Lv, Q., & Wang, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1013322 · Cited by 37 · see citing works
Stress signaling boosts interferon-induced gene transcription in macrophages
Boccuni, L., Podgorschek, E., Schmiedeberg, M., Platanitis, E., Traxler, P. M., Fischer, P., Schirripa, A., Novoszel, P., Nebreda, Á. R., Arthur, J. S. C., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abq5389 · Cited by 36 · see citing works
Self-citationMonoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child
Lévy, R., Zhang, P., Bastard, P., Dorgham, K., Melki, I., Hadchouel, A., Hartoularos, G. C., Neven, B., Castelle, M., Roy, C., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114390118 · Cited by 36 · see citing works
Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
Jalkanen, J. M., Pettilä, V., Karvonen, M., Huttunen, T., Mandelin, J., Jalkanen, M., Malmberg, M., Elima, K., Bellingan, G. J., Ranieri, V. M., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06086-3 · Cited by 35 · see citing works
The protein landscape of chronic lymphocytic leukemia
Meier‐Abt, F., Lu, J., Cannizzaro, E., Pohly, M. F., Kummer, S., Pfammatter, S., Kunz, L., Collins, B. C., Nadeu, F., Lee, K.-S., et al. (2021) · Blood · doi:10.1182/blood.2020009741 · Cited by 34 · see citing works
Chaumette, T., Cinotti, R., Mollé, A., Solomon, P., Castain, L., Fourgeux, C., McWilliam, H. E. G., Misme-Aucouturier, B., Broquet, A. H., Jacqueline, C., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2324oc · Cited by 33 · see citing works
Waseem, M., Imtiaz, A., Alexander, A., Graham, L. V. D., & Contreras-Galindo, R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102812 · Cited by 33 · see citing works
Zhang, C., Feng, Y., Tam, C., Wang, N., & Feng, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733171 · Cited by 33 · see citing works
Mouse B2 SINE elements function as IFN-inducible enhancers
Horton, I., Kelly, C. J., Dziulko, A., Simpson, D. M., & Chuong, E. B. (2023) · eLife · doi:10.7554/elife.82617 · Cited by 32 · see citing works
Sekrecka, A., Kluzek, K., Sekrecki, M., Boroujeni, M. E., Hassani, S., Yamauchi, S., Sada, K., Wesoły, J., & Bluyssen, H. A. R. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04830-8 · Cited by 32 · see citing works
Wen, C., Wang, L., Piffkó, A., Chen, D., Yu, X., Zawieracz, K., Bugno, J., Yang, K., Naccasha, E. Z., Ji, F., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci181612 · Cited by 33 · see citing works
Impact of Age-, Cancer- and Treatment-Driven Inflammation on T Cell Function and Immunotherapy
Quinn, K. M., Kartikasari, A. E. R., Cooke, R. E., Koldej, R. M., Ritchie, D. S., & Plebanski, M. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0520-466r · Cited by 31 · see citing works
Rabaan, A. A., Mutair, A. S. A., Alhumaid, S., Garout, M. A., Alsubki, R. A., Alshahrani, F. S., Alfouzan, W. A., Alestad, J. H., Alsaleh, A. E., Al-Mozaini, M., et al. (2022) · Medicina · doi:10.3390/medicina58050680 · Cited by 31 · see citing works
Walter, K. R., Balko, J. M., & Hagan, C. R. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1758547 · Cited by 31 · see citing works
Kuriyama, Y., Shimizu, A., Kanai, S., Oikawa, D., Motegi, S., Tokunaga, F., & Ishikawa, O. (2021) · Scientific Reports · doi:10.1038/s41598-021-02522-6 · Cited by 31 · see citing works
TYK2 in Tumor Immunosurveillance
Karjalainen, A., Shoebridge, S., Krunic, M., Simonović, N., Tebb, G., Macho‐Maschler, S., Strobl, B., & Müller, M. M. (2020) · Cancers · doi:10.3390/cancers12010150 · Cited by 31 · see citing works
Self-citationPezoldt, J., Wiechers, C., Erhard, F., Rand, U., Bulat, T., Beckstette, M., Brendolan, A., Huehn, J., Kalinke, U., Mueller, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02882-9 · Cited by 30 · see citing works
Zezulin, A. U., Yen, D. P., Howell, E., Yen, D., Bresciani, E., Diemer, J. L., Ren, J., Ahmad, M. H., Castilla, L. H., Touw, I. P., et al. (2023) · Genes & Development · doi:10.1101/gad.350418.123 · Cited by 30 · see citing works
Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
Kim, J. J., Kim, K. S., Eom, J., Lee, J.-B., & Seo, J.-Y. (2019) · Immune Network · doi:10.4110/in.2019.19.e33 · Cited by 29 · see citing works
The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes
Russell, M. A., Richardson, S. J., & Morgan, N. G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1270325 · Cited by 28 · see citing works
Transcriptional control of interferon-stimulated genes
Babadei, O., Strobl, B., Müller, M. M., & Decker, T. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107771 · Cited by 28 · see citing works
Self-citationWang, D., Fu, Z., Gao, L., Zeng, J., Xiang, Y., Zhou, L., Tong, X., Wang, X., & Lu, J. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.01.024 · Cited by 27 · see citing works
Quarleri, J. F., & Delpino, M. V. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.003 · Cited by 27 · see citing works
A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition
Biswal, M. N., Yao, W., Lu, J., Chen, J., Morrison, J. M., Hai, R., & Song, J. (2024) · Communications Biology · doi:10.1038/s42003-024-05768-8 · Cited by 25 · see citing works
Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
Geetha, A. R. S. J., Fischer, K., Babadei, O., Smesnik, G., Vogt, A., Platanitis, E., Müller, M. M., Farlik, M., & Decker, T. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00092-7 · Cited by 25 · see citing works
Self-citationMakuch, E., Jasyk, I., Kula, A., Lipiński, T., & Siednienko, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314915 · Cited by 25 · see citing works
Nowicka, H., Sekrecka, A., Błaszczyk, K., Kluzek, K., Chang, C.-Y., Wesoły, J., Lee, C., & Bluyssen, H. A. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417635 · Cited by 24 · see citing works
Donati, B., Reggiani, F., Torricelli, F., Santandrea, G., Rossi, T., Bisagni, A., Gasparini, E., Neri, A., Cortesi, L., Ferrari, G., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0076 · Cited by 24 · see citing works
Mariani, M. K., Dasmeh, P., Fortin, A., Caron, E., Kalamujic, M., Harrison, A. N., Hotea, D. I., Kasumba, D. M., Cervantes-Ortiz, S., Mukawera, E., et al. (2019) · Cells · doi:10.3390/cells8080919 · Cited by 24 · see citing works
Canar, J., Darling, K., Dadey, R., & Gamero, A. M. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156081 · Cited by 23 · see citing works
Wüst, S., Schad, P. S., Burkart, S. S., & Binder, M. (2021) · Cells · doi:10.3390/cells10102600 · Cited by 23 · see citing works
The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
Detilleux, D., Raynaud, P., Pradet‐Balade, B., & Helmlinger, D. (2022) · eLife · doi:10.7554/elife.69705 · Cited by 22 · see citing works
Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican
Brunn, D., Turkowski, K., Günther, S., Weigert, A., Muley, T., Kriegsmann, M., Winter, H., Dammann, R., Stathopoulos, G. T., Thomas, M., et al. (2021) · Cancers · doi:10.3390/cancers13020208 · Cited by 21 · see citing works
USP18 is an essential regulator of muscle cell differentiation and maturation
Olie, C. S., Pinto-Fernández, A., Damianou, A., Vendrell, I., Mei, H., den Hamer, B., van der Wal, E., de Greef, J. C., Aronica, E., Raz, V., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05725-z · Cited by 21 · see citing works
N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma
Miranda, A., Pattnaik, S., Hamilton, P. T., Fuss, M. A., Kalaria, S., Laumont, C. M., Smazynski, J., Mesa, M., Banville, A. C., Jiang, X., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj5428 · Cited by 20 · see citing works
Mechanisms encoding STAT functional diversity for context-specific inflammatory responses
Myers, S. A., & Gottschalk, R. A. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.01.001 · Cited by 20 · see citing works
Sharma, B. R., Karki, R., Sundaram, B., Wang, Y., Vogel, P., & Kanneganti, T. (2022) · Cancers · doi:10.3390/cancers14040919 · Cited by 20 · see citing works
Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response
An, L., Zhao, X., Gong, X.-Y., Li, Y., Qu, Z.-L., Sun, H.-Y., Guo, W., Dan, C., Gui, J., & Zhang, Y.-B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.861262 · Cited by 20 · see citing works
Bose, D., Lin, X., Gao, L., Wei, Z., Pei, Y., & Robertson, E. S. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00911-9 · Cited by 20 · see citing works
Huang, Z., Mai, Z., Kong, C., You, J., Lin, S., Gao, C., Zhang, W., Chen, X., Xie, Q., Wang, H., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107472 · Cited by 20 · see citing works
Exposing the Two Contrasting Faces of STAT2 in Inflammation
Duodu, P., Sosa, G., Canar, J., Chhugani, O., & Gamero, A. M. (2022) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2022.0117 · Cited by 19 · see citing works
Epigenetic signals that direct cell type–specific interferon beta response in mouse cells
Muckenhuber, M., Seufert, I., Müller‐Ott, K., Mallm, J., Klett, L. C., Knotz, C., Hechler, J., Kepper, N., Erdel, F., & Rippe, K. (2023) · Life Science Alliance · doi:10.26508/lsa.202201823 · Cited by 19 · see citing works
Xu, J. X., Xu, F. Z., Furbish, A. B., Braxton, A. M., Brumfield, B., Helke, K. L., & Peterson, Y. K. (2024) · Communications Biology · doi:10.1038/s42003-024-06051-6 · Cited by 18 · see citing works
IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages
Chavez, C., Lin, K., Malveaux, A., Gorin, A. M., Brizuela, S., Cheng, Q. J., & Hoffmann, A. (2025) · Science Signaling · doi:10.1126/scisignal.ado8860 · Cited by 18 · see citing works
Budroni, V., & Versteeg, G. A. (2021) · Viruses · doi:10.3390/v13040584 · Cited by 18 · see citing works
STAT1 N-terminal domain discriminatively controls type I and type II IFN signaling
Göder, A., Ginter, T., Heinzel, T., Stroh, S., Fahrer, J., Henke, A., & Krämer, O. H. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155552 · Cited by 18 · see citing works
Liu, Q., Li, J., Zong, Q., Duan, Z., Liu, F., Duan, W., Ruan, M., Zhang, H., Liu, Y., Zhou, Q., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112219 · Cited by 17 · see citing works
The diverse interaction of metabolism, immune response, and viral pathogens
Kanno, T., Miyako, K., & Endo, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1619926 · Cited by 17 · see citing works
Demiröz, D., Platanitis, E., Bryant, M., Fischer, P., Prchal‐Murphy, M., Lercher, A., Lassnig, C., Baccarini, M., Müller, M. M., Bergthaler, A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009697 · Cited by 17 · see citing works
Self-citationLeviyang, S. (2021) · Cytokine X · doi:10.1016/j.cytox.2021.100056 · Cited by 17 · see citing works
Heterogeneity and functions of the 13 IFN‐α subtypes – lucky for some?
Moreau, T., Bondet, V., Rodero, M. P., & Duffy, D. (2023) · European Journal of Immunology · doi:10.1002/eji.202250307 · Cited by 17 · see citing works
Zettl, U. K., Rommer, P. S., Aktaş, O., Wagner, T. B., Richter, J., Oschmann, P., Cepek, L., Elias-Hamp, B., Gehring, K., Chan, A., et al. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2248391 · Cited by 17 · see citing works
Boroujeni, M. E., Łopacinska, N., Antonczyk, A., Kluzek, K., Wesoły, J., & Bluyssen, H. A. R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1590953 · Cited by 16 · see citing works
IFN-I signaling in cancer: the connection with dysregulated Insulin/IGF axis
Vella, V., Francesco, E. M. D., Bonavita, E., Lappano, R., & Belfiore, A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.04.009 · Cited by 16 · see citing works
Córdova-Dávalos, L. E., Hernández-Mercado, A., Barrón-García, C. B., Rojas‐Martínez, A., Jiménez, M., Salinas, E., & Cervantes‐García, D. (2022) · Virus Genes · doi:10.1007/s11262-022-01932-6 · Cited by 16 · see citing works
Zuo, W., Liu, X., Chen, J., Zuo, W., Yin, Y., Nie, X., Tang, P., Huang, Y., Yu, Q., Hu, Q., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00165.2023 · Cited by 16 · see citing works
Schiefer, S., & Hale, B. G. (2024) · Nature Communications · doi:10.1038/s41467-024-48800-5 · Cited by 16 · see citing works
Ni, W., Li, W., Cai, Z., Guo, W., Zheng, Y., Zhao, Y., Wu, Z., Liang, S., Ye, J., Guo, X., et al. (2024) · Journal of Virology · doi:10.1128/jvi.01516-24 · Cited by 16 · see citing works
Cao, Y., Chin, A. W. H., Gu, H., Li, M., Gu, Y., Lau, S. P. N., Hui, K. P. Y., Chan, M. C. W., & Poon, L. L. M. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012854 · Cited by 16 · see citing works
The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon Evasion
Parisien, J.-P., Lenoir, J. J., Alvarado, G., & Horvath, C. M. (2021) · Journal of Virology · doi:10.1128/jvi.01301-21 · Cited by 16 · see citing works
Novel subsets of peripheral immune cells associated with promoting stroke recovery in mice
Gu, Y., Zhang, X., Li, H., Wang, R., Jin, C., Wang, J., Jin, Z., Lü, J., Ling, C., Shao, F., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14518 · Cited by 15 · see citing works
Łopacinska, N., Wesoły, J., & Bluyssen, H. A. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010205 · Cited by 14 · see citing works
Ohnezeit, D., Huang, J., Westerkamp, U., Brinschwitz, V., Schmidt, C., Günther, T., Czech‐Sioli, M., Weißelberg, S., Schlemeyer, T., Nakel, J., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012426 · Cited by 14 · see citing works
Schmitt, M., Gallistl, J., Schüler‐Toprak, S., Fritsch, J. H., Buechler, C., Ortmann, O., & Treeck, O. (2022) · Cancers · doi:10.3390/cancers14174108 · Cited by 14 · see citing works
- Authors
- Platanitis, E., Demiroz, D., Schneller, A., Fischer, K., Capelle, C., Hartl, M., Gossenreiter, T., Müller, M., Novatchkova, M., & Decker, T.
- Affiliations
- University of Vienna (AT)
- University of Veterinary Medicine Vienna (AT)
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Decker, Thomas
- ORCID
- Venue
- Nature Communications
- Published
- 2019-07-02
- Volume
- 10
- Issue
- 1
- Pages
- 2921-2921
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6606597
- OpenAlex
- W2955932976
- Cited by
- 233
- References
- 83
- Citations by year
- 2026: 46 · 2025: 28 · 2024: 35 · 2023: 39 · 2022: 35 · 2021: 28 · 2020: 16 · 2019: 6
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Austrian Science Fund (P 25186-B22, SFB F6103)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- ISGF3, STAT1, IRF9, JAK/STAT signaling, type I interferon, interferon-gamma, macrophages, transcription factor binding, promoter binding
- MeSH terms
- RAW 264.7 Cells, Animals, Female, Gene Expression Regulation, Humans, Interferons, Macrophages, Male, Mice, Inbred C57BL, Promoter Regions, Genetic, Transcription, Genetic, Mice, Knockout, STAT1 Transcription Factor, STAT2 Transcription Factor, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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