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Cited by 128Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMultiple Sclerosis Research Studies

Oligodendrocytes express synaptic proteins that modulate myelin sheath formation

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Hughes, Alexandria N., Appel, Bruce·2019·Nature Communications
DOI 10.1038/s41467-019-12059-yPMC PMC6739339
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Abstract

Vesicular release from neurons promotes myelin sheath growth on axons. Oligodendrocytes express proteins that allow dendrites to respond to vesicular release at synapses, suggesting that axon-myelin contacts use similar communication mechanisms as synapses to form myelin sheaths. To test this, we used fusion proteins to track synaptic vesicle localization and membrane fusion in zebrafish during developmental myelination and investigated expression and localization of PSD95, a dendritic post-synaptic protein, within oligodendrocytes. Synaptic vesicles accumulate and exocytose at ensheathment sites with variable patterning and most sheaths localize PSD95 with patterning similar to exocytosis site location. Disruption of candidate PDZ-binding transsynaptic adhesion proteins in oligodendrocytes cause variable effects on sheath length and number. One candidate, Cadm1b, localizes to myelin sheaths where both PDZ binding and extracellular adhesion to axons mediate sheath growth. Our work raises the possibility that axon-glial communication contributes to myelin plasticity, providing new targets for mechanistic unraveling of developmental myelination.

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Cited by

Sorted by citations

Authors
Hughes, A. N., & Appel, B.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Appel, Bruce
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2019-09-11
Volume
10
Issue
1
Pages
4125-4125
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-019-12059-y
PMC
PMC6739339
OpenAlex
W2972635730
Cited by
128
References
12
Citations by year
2026: 12 · 2025: 24 · 2024: 17 · 2023: 14 · 2022: 15 · 2021: 24 · 2020: 20 · 2019: 2
FWCI
5.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • U.S. Department of Health & Human Services | National Institutes of Health (NS046668)
  • National Science Foundation (DGE-1553798)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
oligodendrocytes, myelination, developmental myelination, synaptic vesicle exocytosis, PSD-95, synaptic proteins, myelin plasticity, zebrafish
MeSH terms
Animals, Axons, Exocytosis, Models, Biological, Myelin Sheath, Nerve Tissue Proteins, Oligodendroglia, Synapses, Synaptic Vesicles, Transcription Factors, Zebrafish, Cell Adhesion Molecules

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