Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia
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Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 cases and 4965 healthy controls, using functional gene group analysis. Identifying groups of genes with similar cellular function rather than genes in isolation may have clinical implications for finding additional drug targets. We found that a group of 1026 synaptic genes was significantly associated with the risk of schizophrenia (P=7.6 × 10(-11)) and more strongly associated than 100 randomly drawn, matched control groups of genetic variants (P<0.01). Subsequent analysis of synaptic subgroups suggested that the strongest association signals are derived from three synaptic gene groups: intracellular signal transduction (P=2.0 × 10(-4)), excitability (P=9.0 × 10(-4)) and cell adhesion and trans-synaptic signaling (P=2.4 × 10(-3)). These results are consistent with a role of synaptic dysfunction in schizophrenia and imply that impaired intracellular signal transduction in synapses, synaptic excitability and cell adhesion and trans-synaptic signaling play a role in the pathology of schizophrenia.
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Genes assigned to NeuN+ specific peaks are involved in specialized synaptic functions including exocytosis, intracellular signal transduction, and synaptic plasticity.
“Within a synapse, they were involved in specialized functions including exocytosis, intracellular signal transduction, and synaptic plasticity35 (Fig. 2e).”
From Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders (2021) · cites this paper as [35]
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Modulation of Neural Networks by Interleukin-1
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- Authors
- the International Schizophrenia Consortium, Lips, E. S., Cornelisse, L. N., Toonen, R. F., Min, J. L., Hultman, C. M., Holmans, P. A., O'Donovan, M. C., Purcell, S. M., Smit, A. B., Verhage, M., Sullivan, P. F., Visscher, P. M., & Posthuma, D.
- Affiliations
- Amsterdam Neuroscience (NL)
- Uppsala University (SE)
- Cardiff University (GB)
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- QIMR Berghofer Medical Research Institute (AU)
- Venue
- Molecular Psychiatry
- Published
- 2011-09-20
- Volume
- 17
- Issue
- 10
- Pages
- 996-1006
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3449234
- OpenAlex
- W2109970693
- Cited by
- 167
- References
- 36
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 17 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 17 · 2014: 23 · 2013: 16 · 2012: 16
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Molecular Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Northwestern University
- European Commission (241498, FP7 HEALTH, 242167)
- Koninklijke Nederlandse Akademie van Wetenschappen
- ZonMw (00812)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO 480‐05‐003, 480- 05-003, 051.07.004, 452-05-318, 00812)
- Centre for Medical Systems Biology
- Medical Research Council
- National Health and Medical Research Council (613672, 389892)
- FP7 Health (242167, HEALTH-F2-2009-241498, F2-2009-241498)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- schizophrenia, synaptic dysfunction, synaptic genes, genetic risk factors, intracellular signaling, synaptic excitability, cell adhesion, trans-synaptic signaling, polygenic inheritance, therapeutic target
- MeSH terms
- Cell Adhesion, Female, Genotype, Humans, Male, Risk Factors, Schizophrenia, Synapses, Signal Transduction, Linkage Disequilibrium, Case-Control Studies, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Calcium Channels, L-Type, PubMed, White People, Intracellular Signaling Peptides and Proteins, Genome-Wide Association Study
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