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Cited by 69T-cell and B-cell ImmunologyLymphatic System and DiseasesImmunotherapy and Immune Responses

Lymphatic endothelial cells prime naive CD8+ T cells into memory cells under steady-state conditions

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Vokali, Efthymia, Yu, Shann S., Hirosue, Sachiko, Rinçon-Restrepo, Marcela, V. Duraes, Fernanda, Scherer, Stefanie, Corthésy-Henrioud, Patricia, Kilarski, Witold W. +4 more·2020·Nature Communications
DOI 10.1038/s41467-019-14127-9PMC PMC6985113
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Abstract

Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8 + T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8 + T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8 + T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge.

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  • Some responding T cells develop into memory T cells with a capacity to rapidly respond to subsequent antigenic challenge.

    “However, some responding T cells develop into memory T cells with a capacity to rapidly respond to subsequent antigenic challenge (130).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [130]

  • LECs can directly present antigens on MHC class I to CD8 T cells.

    “Last, several studies have indicated that LECs themselves can directly present antigens on major histocompatibility complex class I to CD8 T cells (128–130).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [130]

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Authors
Vokali, E., Yu, S. S., Hirosue, S., Rinçon-Restrepo, M., V. Duraes, F., Scherer, S., Corthésy-Henrioud, P., Kilarski, W. W., Mondino, A., Zehn, D., Hugues, S., & Swartz, M. A.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • University of Chicago (US)
  • Swiss Vaccine Research Institute (CH)
  • IRCCS Ospedale San Raffaele (IT)
  • University of Geneva (CH)
Corresponding author
Swartz, Melody A.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2020-01-27
Volume
11
Issue
1
Pages
538-538
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-019-14127-9
PMC
PMC6985113
OpenAlex
W3002285817
Cited by
69
References
6
Citations by year
2026: 5 · 2025: 5 · 2024: 12 · 2023: 14 · 2022: 12 · 2021: 16 · 2020: 5
FWCI
4.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • University of Chicago
  • École Polytechnique Fédérale de Lausanne
  • Swiss Cancer Research Foundation
  • National Institutes of Health
  • National Cancer Institute (R01CA219304, R01CA253248)
  • FP7 Ideas: European Research Council (323053)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
lymphatic endothelial cells, CD8+ T cells, T cell memory, central memory T cells, stem cell-like memory T cells, T cell priming, lymph nodes, apoptosis, effector differentiation, memory retrieval, bacterial infection prevention, T cell homeostasis
MeSH terms
Animals, Immunologic Memory, Mice, Inbred C57BL, Mice, Transgenic, CD8-Positive T-Lymphocytes, Gene Expression Profiling, Endothelial Cells, Cell Proliferation

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