The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma
Open accessAbstract
The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) related cirrhosis, with or without HCC, and evaluate its effect on the peripheral immune response in an ex vivo model. We find that dysbiosis characterises the microbiota of patients with NAFLD-cirrhosis, with compositional and functional shifts occurring with HCC development. Gene function of the microbiota in NAFLD-HCC supports short chain fatty acid production, and this is confirmed by metabolomic studies. Ex vivo studies show that bacterial extracts from the NAFLD-HCC microbiota, but not from the control groups, elicit a T cell immunosuppressive phenotype, characterised by expansion of regulatory T cells and attenuation of CD8 + T cells. Our study suggest that the gut microbiota in NAFLD-HCC is characterised by a distinctive microbiome/metabolomic profile, and can modulate the peripheral immune response.
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1 retracted
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Metabolic reprogramming in the tumor microenvironment of liver cancer
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“Ex vivo studies showed that gut bacteria convert dietary fiber into short-chain fatty acids in MASLD-HCC, leading to an immunosuppressive TME with an elevated CD4 + Treg cell/ CD8 + T-cell ratio [208].”
Background
Metadata
- Authors
- Behary, J., Amorim, N., Jiang, X.-T., Raposo, A., Gong, L., McGovern, E., Ibrahim, R., Chu, F., Stephens, C., Jebeili, H., Fragomeli, V., Koay, Y. C., Jackson, M., O’Sullivan, J., Weltman, M., McCaughan, G., El-Omar, E., & Zekry, A.
- Venue
- Nature Communications
- Published
- 2021-01-08
- Volume
- 12
- Issue
- 1
- Pages
- 187-187
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3120427380
- Cited by
- 470
- References
- 65
- FWCI
- 20.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Behary, J., Amorim, N., Jiang, X.-T., Raposo, A., Gong, L., McGovern, E., Ibrahim, R., Chu, F., Stephens, C., Jebeili, H., Fragomeli, V., Koay, Y. C., Jackson, M., O’Sullivan, J., Weltman, M., McCaughan, G., El-Omar, E., & Zekry, A. (2021). Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma. Nature Communications. https://doi.org/10.1038/s41467-020-20422-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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