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The path to leptomeningeal metastasis

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Central Nervous System Macrophages in Health and Disease

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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

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Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults

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Brain aging and rejuvenation at single-cell resolution

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Neuroinflammatory Proteins in Huntington’s Disease: Insights into Mechanisms, Diagnosis, and Therapeutic Implications

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Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases

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Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

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Immune conversations at the border: meningeal immunity in health and disease

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Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity

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Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain

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Systems immunology insights into brain metastasis

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Deciphering the temporal transcriptional landscape of human fetal leptomeninges

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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

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Mechanisms and environmental factors shaping the ecosystem of brain macrophages

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Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins

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Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegenerationPreprint

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Fibroblast reprogramming in the dura mater of NTG-induced migraine-related chronic hypersensitivity model drives monocyte infiltration via Angptl1-dependent stromal signaling

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Border-associated macrophages: From physiology to therapeutic targets in Alzheimer's disease

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Drivers and shapers of macrophages specification in the developing brain

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Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions

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The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease

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Skull bone marrow immunity in brain health and disease: mechanisms and models

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Single-Cell Approaches Define the Murine Leptomeninges: Cortical Brain Interface as a Distinct Cellular Neighborhood Composed of Neural and Non-neural Cell Types

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Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions

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An integrative layer-resolved atlas of the adult human meningesPreprint

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Cell atlas of the developing human meninges reveals a dura origin of meningiomaPreprint

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A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s DiseasePreprint

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Mechanical contrast between brain and leptomeninges: Insights into leptomeningeal cell and astrocyte responses to mechanical stiffness alterations

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Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenationPreprint

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Roles of central nervous system resident and recruited macrophages in the brain barrier system

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Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus

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Decoding the spatiotemporal development of human meninges

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Amyloid beta-induced signalling in leptomeningeal cells and its impact on astrocyte response

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Ontogeny and colonization of embryonic border-associated macrophages and their role in neurodevelopment

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Some Basics on Innate Neuroimmunology for Nonspecialists

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From origins to nomenclature: illuminating the landscape of CNS fibroblasts and fibroblast-like cells

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Current evidence on the cell of origin of meningiomas disputes the arachnoid cap cell dogma

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Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

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Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts

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From glia limitans to glial scars: in vitro co-culture studies of the astrocyte and meningeal interaction

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Living rent free in your head: resident memory T cells

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Layered neuroimmune interfaces at CNS borders: Stress reshapes CNS immunity

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Macrophage IL-1β turns meningeal fibroblasts into inflammatory amplifiers in pneumococcal infection

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Meningeal immunity and “Interstitial” therapy: a new paradigm for immunotherapy in glioblastoma

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Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer

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A single-cell atlas of the mouse dural meninges reveals pervasive sex differences across cellular compartments

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Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas

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Conserved cellular architecture and developmental mechanisms of the zebrafish meningesPreprint

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Developmental contributions to co-evolution of brain and skull

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Beyond the Glial Scar: Fibroblasts as Dynamic Coordinators of Neuroprotection and Neuroinflammation Post-Brain Injury

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Multiomic Characterization of Meningiomas Informs Cell of Origin and Identifies Immune Dysregulation at the Blood-CSF BarrierPreprint

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Engulfment by brain macrophages in a short-lived vertebratePreprint

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Quantitative imaging of corneal endothelial development reveals dynamic but resilient monolayerPreprint

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Central nervous system involvement in acute lymphoblastic leukemia: pathogenesis and targeted therapy

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Brain Injury Caused by Activation of the Immune System

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Engulfment by brain macrophages in a short-lived vertebratePreprint

Nagvekar, R., Pogson, A. N., Kalakuntla, P. R., Barr, H. J., Jaimes, A. M. M., Perry, S., Costa, E. K., Chen, J., Boos, F., Negredo, P. N., et al. (2026) · eLife · doi:10.7554/elife.112503.1

Engulfment by brain macrophages in a short-lived vertebratePreprint

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Gut‐Meningeal Immunity: A Missing Link in Neuroinflammatory Disorders

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Defining a leptomeningeal blood–cerebrospinal fluid barrier as a specialized vascular interfacePreprint

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Mural Lymphatic Endothelial Cells at CNS Borders: Endothelial Heterogeneity, Functional Specialization, and Cross-Species Perspectives

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Border-Associated Macrophage Migrasomes in Alzheimer’s Disease: An Emerging Aβ–Senescence–Microglia Axis?

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A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration

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Common viral infections seed regionally distinct resident memory T cells in the human CNSPreprint

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Air-jet Pneumodissection in Neuroanatomy: a new method for the study of White Matter anatomy in the Human Brain

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Common viral infections seed regionally distinct resident memory T cells in the human CNSPreprint

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Lipids at the meningeal-tumor interface: aging, anatomical niches, and meningioma biology

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Elucidating Cell Diversity and Functions of Human Brain Borders in Alzheimer’s Disease

Kearns, N. A., Iatrou, A., Avey, D. R., Yu, C., Philippe, T. J., Flood, D. J., Tissera, S. L. D., Mullaney, Z. M., Xu, J., Gaiteri, C., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.078551

Decline in adaptive immune responses within human leptomeningesduring Alzheimer's Disease progression

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CNS Immune Surveillance in Alzheimer’s Disease

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A new blueprint of brain border immunity

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Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory lossPreprint

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