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Cited by 27Extracellular vesicles in diseaseCancer Cells and MetastasisMesenchymal stem cell research

Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation

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Valcz, Gábor, Buzás, Edit Irén, Szállási, Zoltán, Kalmár, Alexandra, Krenács, Tibor, Tulassay, Zsolt, Igaz, Péter, Molnár, Béla·2018·npj Breast Cancer
DOI 10.1038/s41523-018-0071-9PMC PMC6048124
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Abstract

Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the dynamic interplay between the malignant cell populations and their stromal fibroblasts are important determinants of metastatic tumor invasion. Important mediators of these interactions are the small, membrane-enclosed extracellular vesicles, in particular exosomes. Both cancer cell and fibroblast-derived exosomes carry a set of regulatory molecules, including proteins and different species of RNA, which cooperatively support metastatic tumor spread. Here, we briefly overview potential links between cancer stem cells and the exosome-mediated fibroblast-enriched metastatic niche formation to discuss their role in the promotion of tumor growth and metastatic expansion in breast carcinoma models.

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  • Bidirectional transport of exosomes containing different RNA species and proteins between cancer stem cells and the fibroblast-rich microenvironment promotes tumor growth and metastatic outbreak in breast carcinoma models.

    “That, bidirectional transport of exosomes containing different species of RNA (e.g. miRNA) and proteins between cancer stem cells and the fibroblast-rich microenvironment is shown to promote the growth of the tumor and the metastatic outbreak in breast carcinoma models [172].”

    From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [172]

  • Exosomes are key to maintaining homeostasis of their releasing cells.

    “These nanoparticles called exosomes are key to maintain homeostasis of their releasing (originating) cells [169–172].”

    From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [172]

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Cited by

Sorted by citations

Authors
Valcz, G., Buzás, E. I., Szállási, Z., Kalmár, A., Krenács, T., Tulassay, Z., Igaz, P., & Molnár, B.
Affiliations
  • Semmelweis University (HU)
  • Boston Children's Hospital (US)
Corresponding author
Valcz, Gábor
ORCID
Venue
npj Breast Cancer
Publisher
Springer Science and Business Media LLC
Published
2018-07-16
Volume
4
Issue
1
Pages
18-18
ISSN
2374-4677 (ISSN-L)
DOI
10.1038/s41523-018-0071-9
PMC
PMC6048124
OpenAlex
W2818916611
Cited by
27
References
6
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 1
FWCI
0.39
Type
journal article
Language
en
Open access
Licence
Locations
  • npj Breast Cancer (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Semmelweis University Repository (Semmelweis University) (submittedVersion)
Funders
  • Nemzeti Kutatási és Technológiai Hivatal (KMR 12-1-2012-0216, NKVP_16-1-2016-0004)
  • Országos Tudományos Kutatási Alapprogramok (OTKA-K111743)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
exosomes, cancer stem cells, tumor microenvironment, stromal fibroblasts, metastasis, extracellular vesicles, breast cancer, tumor growth

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