Cited by 136Parkinson's Disease Mechanisms and TreatmentsProbiotics and Fermented FoodsGut microbiota and health

Probiotics synergized with conventional regimen in managing Parkinson’s disease

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Sun, Hairong, Zhao, Feiyan, Liu, Yuanyuan, Ma, Teng, Jin, Hao, Quan, Keyu, Leng, Bing, Zhao, Junwu +8 more·2022·npj Parkinson's Disease

Abstract

Parkinson’s disease (PD) is mainly managed by pharmacological therapy (e.g., Benserazide and dopamine agonists). However, prolonged use of these drugs would gradually diminish their dopaminergic effect. Gut dysbiosis was observed in some patients with PD, suggesting close association between the gut microbiome and PD. Probiotics modulate the host’s gut microbiota beneficially. A 3-month randomized, double-blind, placebo-controlled clinical trial was conducted to investigate the beneficial effect of probiotic co-administration in patients with PD. Eighty-two PD patients were recruited and randomly divided into probiotic [ n = 48; Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8), Benserazide, dopamine agonists] and placebo ( n = 34; placebo, Benserazide, dopamine agonists) groups. Finally, 45 and 29 patients from Probio-M8 and placebo groups provided complete fecal and serum samples for further omics analysis, respectively. The results showed that Probio-M8 co-administration conferred added benefits by improving sleep quality, alleviating anxiety, and gastrointestinal symptoms. Metagenomic analysis showed that, after the intervention, there were significantly more species-level genome bins (SGBs) of Bifidobacterium animalis , Ruminococcaceae , and Lachnospira , while less Lactobacillus fermentum and Klebsiella oxytoca in Probio-M8 group ( P < 0.05). Interestingly, Lactobacillus fermentum correlated positively with the scores of UPDRS-III, HAMA, HAMD-17, and negatively with MMSE. Klebsiella oxytoca correlated negatively with feces hardness. Moreover, co-administering Probio-M8 increased SGBs involved in tryptophan degradation, gamma-aminobutyric acid, short-chain fatty acids, and secondary bile acid biosynthesis, as well as serum acetic acid and dopamine levels ( P < 0.05). Taken together, Probio-M8 synergized with the conventional regimen and strengthened the clinical efficacy in managing PD, accompanied by modifications of the host’s gut microbiome, gut microbial metabolic potential, and serum metabolites.

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  • Combined administration of probiotics with a conventional regimen led to a reduction in serum glutamine concentrations in PD patients compared to the placebo group receiving the conventional regimen only.

    “the combined administration of probiotics with conventional regimen led to a reduction in serum glutamine concentrations in PD patients compared to the placebo group receiving the conventional regimen only.”
  • Serotonergic dysfunction is implicated in Alzheimer's disease and Parkinson's disease progression, but probiotic interventions have shown inconsistent effects on serotonin levels in Parkinson's disease.

    “In a recent randomized controlled trial (RCT), no significant changes in serum serotonin levels were observed following a 3-month adjunctive probiotic Bifidobacterium animalis subsp. lactis treatment in PD patients receiving conventional regimen (Benserazide and dopamine agonists).491 Furthermore, the administration of L. plantarum PS128 was ineffective in restoring MPTP-induced serotonin”

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  1. [34]Hsieh TH Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson’s disease Brain Sci. 2020 10 13 10.3390/brainsci10040206 PMC7226147 32244769 · DOI · Paper page

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Authors
Sun, H., Zhao, F., Liu, Y., Ma, T., Jin, H., Quan, K., Leng, B., Zhao, J., Yuan, X., Li, Z., Li, F., Kwok, L.-Y., Zhang, S., Sun, Z., Zhang, J., & Zhang, H.
Affiliations
  • Inner Mongolia Agricultural University (CN)
  • Shandong University (CN)
  • Taishan Medical University (CN)
  • Jinzhou Medical University (CN)
Corresponding author
  • Zhang, Jinbiao
  • Zhang, Heping
Venue
npj Parkinson's Disease
Published
2022-05-24
Volume
8
Issue
1
Pages
62-62
ISSN
2373-8057 (ISSN-L)
OpenAlex
W4281396245
Cited by
136
References
90
Citations by year
2026: 20 · 2025: 39 · 2024: 46 · 2023: 20 · 2022: 11
FWCI
15.27
Type
journal article
Language
en
Open access
Locations
  • npj Parkinson s Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (31720103911)
  • Inner Mongolia Science & Technology Major Projects
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Parkinson's disease, probiotics, Bifidobacterium animalis subsp. lactis, gut microbiota, benserazide, dopamine agonists, sleep quality, anxiety, gastrointestinal symptoms, Lactobacillus fermentum, Klebsiella oxytoca, tryptophan degradation, short-chain fatty acids, bile acid synthesis, dopamine levels, serum metabolites

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