The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines
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The outbreak of 2019-novel coronavirus disease (COVID-19) that is caused by SARS-CoV-2 has spread rapidly in China, and has developed to be a Public Health Emergency of International Concern. However, no specific antiviral treatments or vaccines are available yet. This work aims to share strategies and candidate antigens to develop safe and effective vaccines against SARS-CoV-2.
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mRNA and DNA vaccines may not be able to induce protective efficacy in humans after a single immunization because they typically require multiple administrations over an extended period.
“However, mRNA and DNA vaccines may not be able to induce protective efficacy in humans after a single immunization since, similar to inactivated and recombinant subunit protein vaccines, they typically require multiple administrations over an extended period of time to become effective (19).”
From An <i>Alphavirus</i> -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates (2020) · cites this paper as [19]
The paper says subunit vaccines require multiple booster shots, and Table 1 reports lower immune responses in humans for DNA vaccines. It does not say that both DNA and mRNA vaccines typically require multiple administrations over an extended period, or that a single dose cannot provide protective efficacy in humans. The indexed copy provides section labels but no page numbers. (LLM, conf=0.85)
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- Authors
- Shang, W., Yang, Y., Rao, Y., & Rao, X.
- Affiliations
- Army Medical University (CN)
- Venue
- npj Vaccines
- Published
- 2020-03-06
- Volume
- 5
- Issue
- 1
- Pages
- 18-18
- ISSN
- 2059-0105 (ISSN-L)
- PMC
- PMC7060195
- OpenAlex
- W3010200166
- Cited by
- 275
- References
- 25
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 18 · 2022: 41 · 2021: 72 · 2020: 132
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Vaccines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, vaccine development, candidate antigens, viral vaccines, vaccination strategies, public health emergencies
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