Cited by 1,361Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

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The evolution of commercial drug delivery technologies

Vargason, Ava M., Anselmo, Aaron C., Mitragotri, Samir·2021·Nature Biomedical Engineering

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Abstract

Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.

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Background
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Background

Authors: Vargason, A. M., Anselmo, A. C., & Mitragotri, S.
Affiliations: University of North Carolina at Chapel Hill (US)
Harvard University (US)
Corresponding author: Mitragotri, Samir
ORCID: Vargason, Ava M.
Anselmo, Aaron C.
Mitragotri, Samir
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2021-04-01
Volume: 5
Issue: 9
Pages: 951-967
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-021-00698-w
OpenAlex: W3143156272
Cited by: 1,361
References: 275
Citations by year: 2026: 170 · 2025: 314 · 2024: 366 · 2023: 293 · 2022: 170 · 2021: 48
FWCI: 19.23
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (DGE-1650116)
U.S. Department of Health & Human Services | National Institutes of Health (R35GM137898, 1R01HL143806-01)
United States Department of Defense | Defense Threat Reduction Agency (HDTRA1-15-1-0045)
U.S. Department of Defense (W81XWH-19-2-0011)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: drug delivery technology, small molecules, macromolecules, nucleic acids, proteins, immunoglobulins, medication adherence
MeSH terms: Pharmaceutical Preparations, Humans, Nucleic Acids, Peptides, Proteins, Drug Delivery Systems

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The evolution of commercial drug delivery technologies

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