Cited by 1,361Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

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The evolution of commercial drug delivery technologies

Vargason, Ava M., Anselmo, Aaron C., Mitragotri, Samir·2021·Nature Biomedical Engineering

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Abstract

Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00423-1 · Cited by 11,484
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035389 · Cited by 10,119
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
Maude, S. L., Laetsch, T. W., Buechner, J., Rives, S., Boyer, M., Bittencourt, H., Bader, P., Verneris, M. R., Stefanski, H. E., Myers, G. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709866 · Cited by 5,735
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552

Show all 275 references

Research works printed but not linked: 2

Dost, F. H. Der Blutspiegel: Kinetik der Konzentrationsabläufe in der Kreislaufflüssigkeit (Georg Thieme, 1953).
DeLoach, J. R. & Sprandel, U. (eds) in Bibliotheca Haematologica Vol. 51 (Karger, 1985).

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Arrhenius-model-based degradable oligourethane hydrogels for controlled growth factor release
Tawagi, E., Ung, T. W.-M., Cheng, H. M., & Santerre, J. P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.05.024 · Cited by 12
Highly stable hybrid single-micelle: a universal nanocarrier for hydrophobic bioimaging agents
Zhou, Q., Zhao, T., Liu, M., Yin, D., Liu, M., Elzatahry, A. A. F., Zhang, F., Zhao, D., & Li, X. (2022) · Nano Research · doi:10.1007/s12274-022-4083-2 · Cited by 12
New long-acting injectable microspheres prepared by IVL-DrugFluidic™ system: 1-month and 3-month in vivo drug delivery of leuprolide
Kim, M., Kim, J. H., Kim, S., Maharjan, R., Kim, N. A., & Jeong, S. H. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121875 · Cited by 13
Mathematical modeling of transdermal drug delivery using microneedle
Benslimane, A., Fatmi, S., Taouzinet, L., & Hammiche, D. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.01.028 · Cited by 11
Mechanoresponsive Drug Delivery Systems for Vascular Diseases
Navarro, J. F., & Lomora, M. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202200466 · Cited by 11
Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry
Zhang, W., Yang, W., & Zhou, J. (2023) · Molecules · doi:10.3390/molecules28114422 · Cited by 11
Electrophotographic 3D printing of pharmaceutical films
Kopp, S., Medvedev, V., Tangermann‐Gerk, K., Wöltinger, N., Rothfelder, R., Graßl, F., Heinrich, M. R., Januskaite, P., Goyanes, Á., Basit, A. W., et al. (2023) · Additive manufacturing · doi:10.1016/j.addma.2023.103707 · Cited by 11
“Driven by the demand for smarter and more personalized medicines and treatment, 3DP of pharmaceuticals has emerged and developed significantly in recent years [9 – 12].”
Crab-shaped DNA tetrahedral nanomachine for silencing undruggable mRNA targets in prostate cancer
Wan, F., Liu, Z., Zhang, J., Zhang, W., & Dai, B. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102187 · Cited by 11
Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy
Tao, Y., Li, L., Yang, X., Yin, S., Zhang, Z., Wang, H., Pu, R., Wang, Z., Zhang, Q., Mu, H., et al. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1386076 · Cited by 12
“Lastly, MMHR can utilize the plasticity and programmability of hydrogels to design various shapes and functions, such as cylindrical, hexahedral, spiral, spherical, capsule shapes, etc., to adapt to different drug delivery routes and target sites (Vargason et al., 2021; Jiang et al., 2022).”
BackgroundMethod
Recent advances in the development of poly(ester amide)s-based carriers for drug delivery
Xie, R., Li, J., Zhao, M., & Wu, F. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.102123 · Cited by 11
“…of new-generation therapeutics such as peptides, monoclonal antibodies, nucleic acids, and living cells, new challenges have arisen, especially with stability (peptides), efficiency of intracellular delivery (nucleic acids), and survivability and expansion (living cells) (Vargason et al., 2021).”
Background
Pharmaceutical strategies for optimized mRNA expression
Shi, Y., Mao, J., Wang, S., Ma, S., Luo, L., & You, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122853 · Cited by 11
Dual stimuli-responsive biotinylated polymer–drug conjugate for dual drug delivery
Ghosh, D., Khan, A., Bag, S., Mallick, A. I., & De, P. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01762e · Cited by 11
Therapeutic and responsive release mechanisms of polymer drug conjugates with diverse polymer skeletons
Zhao, W., Sun, K., Yan, J., Sun, Y. Y., & Wei, D. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102526 · Cited by 11
Biomimetic Proteoglycans for Intervertebral Disc (IVD) Regeneration
Chopra, N., Melrose, J., Gu, Z., & Diwan, A. D. (2024) · Biomimetics · doi:10.3390/biomimetics9120722 · Cited by 11
“Various formats have been examined including hydrogels and nanoparticles in the development of multifunctional drug delivery systems [92].”
Biopharmaceutical drug delivery and phototherapy using protein crystals
Zhou, R., Qu, J., Liu, X., Lin, F., Ohulchanskyy, T. Y., Alifu, N., Qu, J., & Yin, D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115480 · Cited by 11
PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration
Goto, A., Komura, S., Kato, K., Maki, R., Hirakawa, A., Aoki, H., Tomita, H., Taguchi, J., Ozawa, M., Matsushima, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59010-y · Cited by 13
“Additionally, we have included a schema illustrating these mice in the revised”
Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound
Abundo, M. P., Tifrea, A. T., Buss, M. T., Barturen‐Larrea, P., Jin, Z., Malounda, D., & Shapiro, M. G. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2423078122 · Cited by 14
“In future studies, the TAPS technology can be extended to a wider range of cargoes ( 63 )—from small - molecule drugs ( ~ 1 nm) to viruses such as adeno - associated virus (>20 nm)—by tuning the hydrogel mesh size relative to the hydrodynamic radius of the payload.”
Double hit strategy using pH-sensitive liposomes containing doxorubicin and pheophorbide-a for combination tumor therapy
Park, E., Lee, D., Lee, Y., Jeong, E., Kim, S., & Koo, H. (2021) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2021.100565 · Cited by 11
Poly(I:C) transfection induces a pro-inflammatory cascade in murine mammary carcinoma and fibrosarcoma cells
Conniff, A. S., Encalada, G., Patel, S., Bhandary, M., Al-Takrouri, F., & Heller, L. C. (2022) · RNA Biology · doi:10.1080/15476286.2022.2084861 · Cited by 11
Applications of Xylitol in Food, Material, Health, and Medical Sector
de Arruda, P. V., Milessi, T. S., Alves-Ferreira, J., Sene, L., Carvalheiro, F., Duarte, L. C., & Felipe, M. D. G. D. A. (2022) · Springer eBooks · doi:10.1007/978-3-031-04942-2_10 · Cited by 11
Will nanomedicine become a good solution for the cardiotoxicity of chemotherapy drugs?
Jiang, Y., Jiang, Y., Li, M., & Yu, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1143361 · Cited by 11
“Based on these advantages, it is feasible to employ nano-delivery systems for anthracyclines to reduce their dose-dependent cardiotoxicity (Vargason et al., 2021).”
Background
Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues
Shaikh, A. Y., Björkling, F., Żabicka, D., Tomczak, M., Urbaś, M., Domračeva, I., Kreicberga, A., & Franzyk, H. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106876 · Cited by 11
Implementing Horizon Scanning as a tool for the strategic development of regulatory guidelines for nanotechnology-enabled health products
Rodríguez-Gómez, F. D., Monferrer, D., Penon, O., & Rivera-Gil, P. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2023.1308047 · Cited by 10
“In response to the decreasing number of new pharmaceuticals, there is a growing trend towards exploring alternative drug delivery methods to increase the safety and efficacy of existing pharmaceuticals (31, 32).”
Background
Light emitting diode (LED) irradiation of liposomes enhances drug encapsulation and delivery for improved cancer eradication
Lee, S., Kim, H. J., Choi, J.-H., Jang, H. J., Cho, H. B., Kim, H.-R., Park, J.-I., Park, K.-S., & Park, K.-H. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.027 · Cited by 10
Antibody‐Conjugated Nanogel with Two Immune Checkpoint Inhibitors for Enhanced Cancer Immunotherapy
Chae, Y. J., Lee, K.-G., Oh, D., Lee, S., Park, Y., & Kim, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400235 · Cited by 11
A Comprehensive Analysis of Biopharmaceutical Products Listed in the FDA’s Purple Book
Chen, F., Zhong, H., Chan, G., & Ouyang, D. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02802-0 · Cited by 11
“There are four strategies of drug delivery for biological therapies: drug modifications, microenvironment modifications, drug delivery system, and drug-device combinations [110].”
Influential
Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery
Xiao, Q., Shang, L., Yang, P., Zhang, L., Wei, Y., Zhao, D., Zhao, Y., Wan, J., Wang, Y., & Wang, D. (2024) · Small Methods · doi:10.1002/smtd.202301664 · Cited by 10
Unlocking the potential of transdermal drug delivery
Li, S., Wu, J., Peng, X., & Feng, X. (2024) · International Journal of Smart and Nano Materials · doi:10.1080/19475411.2024.2366210 · Cited by 11
“The predominant modalities for drug delivery today are oral administration and injection (Figure 1) [2–5].”
Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment
Fu, S., Zheng, A., Wang, L., Chen, J., Zhao, B., Zhang, X., McKenzie, V. A. A., Yang, Z., Leblanc, R. M., Prabhakar, R. S., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00751d · Cited by 10
Hyperactivation of crosslinked lipases in elastic hydroxyapatite microgel and their properties
Jeon, H. W., Lee, J. S., Lee, C. H., Kim, D., Lee, H. S., & Hwang, E. T. (2024) · Journal of Biological Engineering · doi:10.1186/s13036-024-00440-5 · Cited by 10
“DDS enables controlled, targeted release, protecting enzymes and maintaining their effectiveness [6].”
Background
Prospects for the convergence of polyphenols with pharmaceutical drugs in type 2 diabetes: Challenges, risks, and strategies
Allamreddy, S. R., Arora, M., Ganugula, R., Friend, R., Basu, R., & Kumar, M. N. V. R. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001074 · Cited by 10
Overview of Nanofibres as Ideal Drug Delivery Systems for Pharmaceutical and Medicinal Applications
Bashir, R., Ali, T., Raza, S. N., & Khan, N. A. (2024) · BioNanoScience · doi:10.1007/s12668-024-01640-5 · Cited by 10
“Biomolecules or medications can easily functionalize nanofibers [40].”
Actuation‐Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins
Wallace, E. J., O’Dwyer, J., Dolan, E. B., Burke, L. P., Wylie, R., Bellavia, G., Straino, S., Cianfarani, F., Ciotti, G., Serini, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202401744 · Cited by 10

Authors: Vargason, A. M., Anselmo, A. C., & Mitragotri, S.
Affiliations: University of North Carolina at Chapel Hill (US)
Harvard University (US)
Corresponding author: Mitragotri, Samir
ORCID: Vargason, Ava M.
Anselmo, Aaron C.
Mitragotri, Samir
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2021-04-01
Volume: 5
Issue: 9
Pages: 951-967
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-021-00698-w
OpenAlex: W3143156272
Cited by: 1,361
References: 275
Citations by year: 2026: 170 · 2025: 314 · 2024: 366 · 2023: 293 · 2022: 170 · 2021: 48
FWCI: 19.23
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (DGE-1650116)
U.S. Department of Health & Human Services | National Institutes of Health (R35GM137898, 1R01HL143806-01)
United States Department of Defense | Defense Threat Reduction Agency (HDTRA1-15-1-0045)
U.S. Department of Defense (W81XWH-19-2-0011)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: drug delivery technology, small molecules, macromolecules, nucleic acids, proteins, immunoglobulins, medication adherence
MeSH terms: Pharmaceutical Preparations, Humans, Nucleic Acids, Peptides, Proteins, Drug Delivery Systems

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