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The evolution of commercial drug delivery technologies
Abstract
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.
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“The ultimate goal of the development of smart nanoparticles is that the payloads can better serve patients: enhance curative effect, reduce toxicity and prolong survival.276”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [276]
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Metadata
- Authors
- Vargason, A. M., Anselmo, A. C., & Mitragotri, S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Harvard University (US)
- Corresponding author
- Mitragotri, Samir
- Venue
- Nature Biomedical Engineering
- Published
- 2021-04-01
- Volume
- 5
- Issue
- 9
- Pages
- 951-967
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W3143156272
- Cited by
- 1,361
- References
- 275
- Citations by year
- 2026: 170 · 2025: 314 · 2024: 366 · 2023: 293 · 2022: 170 · 2021: 48
- FWCI
- 19.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (DGE-1650116)
- U.S. Department of Health & Human Services | National Institutes of Health (R35GM137898, 1R01HL143806-01)
- United States Department of Defense | Defense Threat Reduction Agency (HDTRA1-15-1-0045)
- U.S. Department of Defense (W81XWH-19-2-0011)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- drug delivery technology, small molecules, macromolecules, nucleic acids, proteins, immunoglobulins, medication adherence
- MeSH terms
- Pharmaceutical Preparations, Humans, Nucleic Acids, Peptides, Proteins, Drug Delivery Systems
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