A low-power stretchable neuromorphic nerve with proprioceptive feedback
Abstract
By relaying neural signals from the motor cortex to muscles, devices for neurorehabilitation can enhance the movement of limbs in which nerves have been damaged as a consequence of injuries affecting the spinal cord or the lower motor neurons. However, conventional neuroprosthetic devices are rigid and power-hungry. Here we report a stretchable neuromorphic implant that restores coordinated and smooth motions in the legs of mice with neurological motor disorders, enabling the animals to kick a ball, walk or run. The neuromorphic implant acts as an artificial efferent nerve by generating electrophysiological signals from excitatory post-synaptic signals and by providing proprioceptive feedback. The device operates at low power (~1/150 that of a typical microprocessor system), and consists of hydrogel electrodes connected to a stretchable transistor incorporating an organic semiconducting nanowire (acting as an artificial synapse), connected via an ion gel to an artificial proprioceptor incorporating a carbon nanotube strain sensor (acting as an artificial muscle spindle). Stretchable electronics with proprioceptive feedback may inspire the further development of advanced neuromorphic devices for neurorehabilitation.
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Monitoring neural electrical signals or neurotransmitters provides insights into physiological and pathological processes, informing the prevention and treatment of neurological disorders.
“Monitoring neural electrical signals or neurotransmitters provides insights into physiological and pathological processes, informing the prevention and treatment of neurological disorders (Cho et al. 2020; Lee, S. et al. 2017; Lee et al. 2022).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Lee et al. 2022
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Wang, C., He, T., Zhou, H., Zhang, Z., & Lee, C. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00118-1 · Cited by 295 · see citing works
- Authors
- Lee, Y., Liu, Y., Seo, D.-G., Oh, J. Y., Kim, Y., Li, J., Kang, J., Kim, J., Mun, J., Foudeh, A. M., Bao, Z., & Lee, T.-W.
- Affiliations
- Seoul National University (KR)
- National University of Singapore (SG)
- Stanford University (US)
- Corresponding author
- Bao, Zhenan
- Lee, Tae-Woo
- ORCID
- Venue
- Nature Biomedical Engineering
- Published
- 2022-08-15
- Volume
- 7
- Issue
- 4
- Pages
- 511-519
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W4292156427
- Cited by
- 177
- References
- 45
- Citations by year
- 2026: 24 · 2025: 50 · 2024: 57 · 2023: 40 · 2022: 6
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-09-08)
- Open access
- closed
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Agency for Science, Technology and Research
- Seoul National University (Creative-Pioneering Researchers Program)
- National Research Foundation of Korea (NRF-2016R1A3B1908431)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- stretchable electronics, proprioceptive feedback, neuroprosthetics, neurorehabilitation, spinal cord injury, lower motor neuron injury, artificial synapses, hydrogel electrodes, low-power electronics
- MeSH terms
- Animals, Electronics, Motor Neurons, Synapses, Nanotubes, Carbon, Mice, Feedback, Sensory
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