Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124

Identification of the haematopoietic stem cell niche and control of the niche size

Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948

Purification and Characterization of Mouse Hematopoietic Stem Cells

Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types

Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Elefant, N., Paul, F., Zaretsky, I., Mildner, A., Cohen, N., Jung, S., Tanay, A., et al. (2014) · Science · doi:10.1126/science.1247651 · Cited by 1,795

Mapping the Mouse Cell Atlas by Microwell-Seq

Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.001 · Cited by 1,597

Neutrophil diversity and plasticity in tumour progression and therapy

Jaillon, S., Ponzetta, A., Mitri, D. D., Santoni, A., Bonecchi, R., & Mantovani, A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0281-y · Cited by 1,333

The bone marrow microenvironment at single-cell resolution

Tikhonova, A. N., Dolgalev, I., Hu, H., Sivaraj, K. K., Hoxha, E., Cuesta-Domínguez, Á., Pinho, S., Akhmetzyanova, I., Gao, J., Witkowski, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1104-8 · Cited by 936

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Xie, X., Shi, Q., Wu, P., Zhang, X., Kambara, H., Su, J., Yu, H., Park, S., Guo, R., Ren, Q., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0736-z · Cited by 894

Heterogeneity of neutrophils

Ng, L. G., Ostuni, R., & Hidalgo, A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0141-8 · Cited by 761

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., Shin, A., Huang, W., Dress, R. J., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.009 · Cited by 719

Macrophage diversity in cancer revisited in the era of single-cell omics

Ma, R., Black, A., & Qian, B. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.04.008 · Cited by 732

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

Alshetaiwi, H. S., Pervolarakis, N., McIntyre, L. L., Ma, D., Nguyen, Q., Rath, J. A., Nee, K., Hernandez, G. A., Evans, K. T., Torosian, L., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aay6017 · Cited by 532

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

Geirsdottir, L., David, E., Keren-Shaul, H., Weiner, A., Bohlen, S. C., Neuber, J., Balic, A., Giladi, A., Sheban, F., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.010 · Cited by 461

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Cohen, M., Giladi, A., Gorki, A.-D., Gelbard-Solodkin, D., Zada, M., Hladik, A., Miklosi, A., Salame, T., Halpern, K. B., David, E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.009 · Cited by 418

MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions

Baran, Y., Bercovich, A., Sebé-Pedrós, A., Lubling, Y., Giladi, A., Chomsky, E., Meir, Z., Hoichman, M., Lifshitz, A., & Tanay, A. (2019) · Genome biology · doi:10.1186/s13059-019-1812-2 · Cited by 392

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Grieshaber‐Bouyer, R., Radtke, F. A., Cunin, P., Stifano, G., Levescot, A., Vijaykumar, B., Nelson-Maney, N., Blaustein, R. B., Monach, P. A., Nigrovic, P. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22973-9 · Cited by 371

Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

Friedman, G., Levi-Galibov, O., David, E., Bornstein, C., Giladi, A., Dadiani, M., Mayo, A., Halperin, C., Pevsner‐Fischer, M., Lavon, H., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0082-y · Cited by 355

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

de Laval, B., Maurizio, J., Kandalla, P. K., Brisou, G., Simonnet, L., Huber, C., Gimenez, G., Matcovitch-Natan, O., Reinhardt, S., David, E., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.017 · Cited by 356

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Nam, A. S., Kim, K.-T., Chaligne, R., Izzo, F., Ang, C., Taylor, J., Myers, R. M., Abu-Zeinah, G., Brand, R., Omans, N. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1367-0 · Cited by 333

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Chavakis, T., Mitroulis, I., & Hajishengallis, G. (2019) · Nature Immunology · doi:10.1038/s41590-019-0402-5 · Cited by 330

Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis

Kwok, A. J., Allcock, A., Ferreira, R. C., Cano-Gamez, E., Smee, M., Burnham, K. L., Zurke, Y.-X., Novak, A., Darwent, M., Baron, T., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01490-5 · Cited by 328

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

Keren-Shaul, H., Kenigsberg, E., Jaitin, D. A., David, E., Paul, F., Tanay, A., & Amit, I. (2019) · Nature Protocols · doi:10.1038/s41596-019-0164-4 · Cited by 292

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

Rodriguez-Fraticelli, A., Weinreb, C., Wang, S., Migueles, R. P., Jankovic, M., Usart, M., Klein, A. M., Lowell, S., & Camargo, F. D. (2020) · Nature · doi:10.1038/s41586-020-2503-6 · Cited by 265

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

Kwok, I., Becht, É., Xia, Y., Ng, M. S. F., Teh, Y. C., Tan, L., Evrard, M., Li, J. L. Y., Tran, H. T., Tan, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.005 · Cited by 270

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Ledergor, G., Weiner, A., Zada, M., Wang, S.-Y., Cohen, Y. C., Gatt, M. E., Snir, N., Magen, H., Koren-Michowitz, M., Herzog-Tzarfati, K., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0269-2 · Cited by 263

Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage

Dress, R. J., Dutertre, C., Giladi, A., Schlitzer, A., Low, I., Shadan, N. B., Tay, A., Lum, J., Kairi, M. F. B. M., Hwang, Y. Y., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0420-3 · Cited by 248

Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Cytlak, U., Resteu, A., Pagan, S., Green, K., Milne, P., Maisuria, S., McDonald, D., Hulme, G., Filby, A. J., Carpenter, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2020.07.003 · Cited by 257

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 237

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Izzo, F., Lee, S. C., Poran, A., Chaligne, R., Gaiti, F., Gross, B., Murali, R. R., Deochand, S. D., Ang, C., Jones, P. W., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0595-4 · Cited by 236

Interrogation of human hematopoiesis at single-cell and single-variant resolution

Ulirsch, J. C., Lareau, C. A., Bao, E. L., Ludwig, L. S., Guo, M. H., Benner, C., Satpathy, A. T., Kartha, V. K., Salem, R. M., Hirschhorn, J. N., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0362-6 · Cited by 208

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Deczkowska, A., David, E., Ramadori, P., Pfister, D., Safran, M., Li, B., Giladi, A., Jaitin, D. A., Barboy, O., Cohen, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01344-3 · Cited by 197

The Myeloid Cell Compartment—Cell by Cell

Bassler, K. E., Schulte-Schrepping, J., Warnat‐Herresthal, S., Aschenbrenner, A. C., & Schultze, J. L. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041728 · Cited by 200

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01059-0 · Cited by 195

A Single-Cell Sequencing Guide for Immunologists

See, P., Lum, J., Chen, J., & Ginhoux, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02425 · Cited by 198

m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment

Cheng, Y., Luo, H., Izzo, F., Pickering, B. F., Nguyen, D. T. T., Myers, R. M., Schurer, A., Gourkanti, S., Brüning, J. C., Vu, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.032 · Cited by 175

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Schultze, J. L., Mass, E., & Schlitzer, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.019 · Cited by 174

Unraveling Hematopoiesis through the Lens of Genomics

Liggett, L. A., & Sankaran, V. G. (2020) · Cell · doi:10.1016/j.cell.2020.08.030 · Cited by 163

Neutrophils in Physiology and Pathology

Aroca-Crevillén, A., Vicanolo, T., Ovadia, S., & Hidalgo, A. (2024) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-015009 · Cited by 159

HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia

Luo, H., Zhu, G., Eshelman, M. A., Fung, T. K., Lai, Q., Wang, F., Zeisig, B. B., Lesperance, J., Ma, X., Shi, C., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.01.014 · Cited by 152

What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity

Musumeci, A. G., Lutz, K., Winheim, E., & Krug, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01222 · Cited by 144

Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy

Long, H., Jia, Q., Wang, L., Fang, W., Wang, Z., Jiang, T., Zhou, F., Zheng, J., Huang, J., Zhou, L., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.018 · Cited by 138

The diverse roles of neutrophils from protection to pathogenesis

Herro, R., & Grimes, H. L. (2024) · Nature Immunology · doi:10.1038/s41590-024-02006-5 · Cited by 156

Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Hou, J., Chen, K.-X., He, C., Li, X., Huang, M., Jiang, Y., Jiao, Y., Xiao, Q.-N., He, W., Liu, L., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00694-0 · Cited by 143

Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act

Yvan‐Charvet, L., & Ng, L. G. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.05.004 · Cited by 137

Putative cell type discovery from single-cell gene expression data

Miao, Z., Moreno, P., Huang, N., Papatheodorou, I., Brazma, A., & Teichmann, S. A. (2020) · Nature Methods · doi:10.26226/morressier.5ebd45acffea6f735881af34 · Cited by 133

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Giladi, A., Wagner, L. K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0661-1 · Cited by 130

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

Gullotta, G. S., Feo, D. D., Friebel, E., Semerano, A., Scotti, G. M., Bergamaschi, A., Butti, E., Brambilla, E., Genchi, A., Capotondo, A., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01505-1 · Cited by 124

Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis

Dong, F., Hao, S., Zhang, S., Zhu, C., Cheng, H., Yang, Z., Hamey, F. K., Wang, X., Gao, A., Wang, F., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0512-1 · Cited by 121

Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function

Yin, R., Chang, J.-W., Li, Y., Gao, Z., Qiu, Q., Wang, Q., Han, G., Chai, J., Feng, M., Wang, P., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.09.014 · Cited by 123

Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

Rhodes, J. W., Tong, O., Harman, A. N., & Turville, S. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01088 · Cited by 125

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

LaFleur, M. W., Nguyen, T. H., Coxe, M. A., Yates, K. B., Trombley, J. D., Weiss, S. A., Brown, F. D., Gillis, J. E., Coxe, D. J., Doench, J. G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09656-2 · Cited by 126

A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System

Grabert, K., Sehgal, A., Irvine, K. M., Wollscheid-Lengeling, E., Ozdemir, D. D., Stables, J., Luke, G. A., Ryan, M. D., Adamson, A., Humphreys, N. E., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000835 · Cited by 114

Pathophysiological role of respiratory dysbiosis in hospital-acquired pneumonia

Roquilly, A., Torres, A., Villadangos, J. A., Netea, M. G., Dickson, R. P., Becher, B., & Asehnoune, K. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30140-7 · Cited by 121

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development

Zhou, W., Yui, M. A., Williams, B. A., Yun, J., Wold, B. J., Cai, L., & Rothenberg, E. V. (2019) · Cell Systems · doi:10.1016/j.cels.2019.09.008 · Cited by 101

The Role of Dendritic Cells During Infections Caused by Highly Prevalent Viruses

Soto, J. A., Gálvez, N. M. S., Andrade, C. A., Pacheco, G. A., Böhmwald, K., Berríos-Rojas, R. V., Bueno, S. M., & Kalergis, A. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01513 · Cited by 110

Generative modeling of single-cell time series with PRESCIENT enables prediction of cell trajectories with interventions

Yeo, G. H. T., Saksena, S. D., & Gifford, D. K. (2021) · Nature Communications · doi:10.1038/s41467-021-23518-w · Cited by 103

Monocyte Differentiation and Heterogeneity: Inter-Subset and Interindividual Differences

Williams, H., Mack, C. D., Baraz, R., Marimuthu, R., Naralashetty, S., Li, S., & Medbury, H. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108757 · Cited by 108

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis

SanMiguel, J. M., Eudy, E., Loberg, M. A., Young, K. A., Mistry, J. J., Mujica, K. D., Schwartz, L. S., Stearns, T. M., Challen, G. A., & Trowbridge, J. J. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0086 · Cited by 95

Neutrophil diversity in inflammation and cancer

Carnevale, S., Ceglie, I. D., Grieco, G., Rigatelli, A., Bonavita, E., & Jaillon, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1180810 · Cited by 96

Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis

Yao, R.-Q., Li, Z., Wang, L., Li, Y.-X., Zheng, L., Dong, N., Wu, Y., Xia, Z., Billiar, T. R., Ren, C., et al. (2022) · Theranostics · doi:10.7150/thno.72760 · Cited by 96

Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression

Mukaida, N., Sasaki, S., & Baba, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103457 · Cited by 94

Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth

Li, Y., Kong, W., Yang, W., Patel, R. M., Casey, E. B., Okeyo-Owuor, T., White, J. M., Porter, S. N., Morris, S. A., & Magee, J. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.08.001 · Cited by 95

Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells

Moshe, N. B. B., Hen‐Avivi, S., Levitin, N., Yehezkel, D., Oosting, M., Joosten, L. A. B., Netea, M. G., & Avraham, R. (2019) · Nature Communications · doi:10.1038/s41467-019-11257-y · Cited by 88

Single-molecule imaging of transcription dynamics in somatic stem cells

Wheat, J. C., Sella, Y., Willcockson, M., Skoultchi, A. I., Bergman, A., Singer, R. H., & Steidl, U. (2020) · Nature · doi:10.1038/s41586-020-2432-4 · Cited by 88

Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation

Liu, X., Zhu, R., Luo, Y., Wang, S., Zhao, Y., Qiu, Z., Zhang, Y. X., Liu, X., Yao, X., Li, X., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.012 · Cited by 91

Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils

Ng, L. G., Liu, Z., Kwok, I., & Ginhoux, F. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081022-113627 · Cited by 91

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing

Watcham, S., Kuciński, I., & Göttgens, B. (2019) · Blood · doi:10.1182/blood-2018-08-835355 · Cited by 86

Immunology in the Era of Single-Cell Technologies

Efremova, M., Vento‐Tormo, R., Park, J.-E., Teichmann, S. A., & James, K. R. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090419-020340 · Cited by 80

Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling

Bellissimo, D. C., Chen, C.-H., Zhu, Q., Bagga, S., Lee, C.-T., He, B., Wertheim, G. B. W., Jordan, M. S., Tan, K., Worthen, G. S., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000785 · Cited by 78

Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells

McClatchy, J., Strogantsev, R., Wolfe, E., Lin, H., Mohammadhosseini, M., Davis, B. A., Eden, C. O., Goldman, D., Fleming, W., Conley, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43697-y · Cited by 86

Dysregulated hematopoiesis in bone marrow marks severe COVID-19

Wang, X., Wen, Y., Xie, X., Liu, Y., Tan, X., Cai, Q., Zhang, Y., Cheng, L., Xu, G., Zhang, S., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00296-9 · Cited by 75

Single-cell sortChIC identifies hierarchical chromatin dynamics during hematopoiesis

Zeller, P. J., Yeung, J., Gaza, H. V., de Barbanson, B., Bhardwaj, V., Florescu, M., van der Linden, R., & van Oudenaarden, A. (2022) · Nature Genetics · doi:10.1038/s41588-022-01260-3 · Cited by 67

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

Thind, M. K., Uhlig, H. H., Glogauer, M., Palaniyar, N., Bourdon, C., Gwela, A., Lancioni, C., Berkley, J. A., Bandsma, R., & Farooqui, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1334205 · Cited by 78

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

Guillamot, M., Ouazia, D., Dolgalev, I., Yeung, S. T., Kourtis, N., Dai, Y., Corrigan, K., Zea-Redondo, L., Saraf, A., Florens, L. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0454-6 · Cited by 70

SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches

Wu, Q., Tian, P., He, D., Jia, Z., He, Y., Luo, W., Lv, X., Wang, Y., Zhang, P., Liang, Y., et al. (2023) · Cell Research · doi:10.1038/s41422-023-00810-6 · Cited by 73

Single-Cell RNA Sequencing: Technological Progress and Biomedical Application in Cancer Research

Xu, C., Zheng, Y., & Xu, K. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00777-0 · Cited by 79

The transcriptional and regulatory identity of erythropoietin producing cells

Kragesteen, B. K., Giladi, A., David, E., Halevi, S., Geirsdóttir, L., Lempke, O. M., Li, B., Bapst, A. M., Xie, K., Katzenelenbogen, Y., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02314-7 · Cited by 67

Plasticity of monocyte development and monocyte fates

Trzebanski, S., & Jung, S. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.07.007 · Cited by 75

The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

Huang, Y., Mouttet, B., Warnatz, H.-J., Risch, T., Rietmann, F., Frommelt, F., Ngo, Q. A., Dobay, M. P., Marovca, B., Jenni, S., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.004 · Cited by 63

Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms

Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.018 · Cited by 68

Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis

Malengier‐Devlies, B., Metzemaekers, M., Wouters, C. H., Proost, P., & Matthys, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766620 · Cited by 64

Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue

Saunders, R. A., Allen, W. E., Pan, X., Sandhu, J., Lu, J., Lau, T. K., Smolyar, K., Sullivan, Z. A., Dulac, C. G., Weissman, J. S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.022 · Cited by 82

Label‐free single cell proteomics utilizing ultrafast LC and MS instrumentation: A valuable complementary technique to multiplexing

Matzinger, M., Mayer, R. L., & Mechtler, K. (2023) · PROTEOMICS · doi:10.1002/pmic.202200162 · Cited by 58

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

Basilico, S., Wang, X.-N., Kennedy, A., Tzelepis, K., Giotopoulos, G., Kinston, S., Quirós, P. M., Wong, K., Adams, D., Carnevalli, L. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15220-0 · Cited by 35

Chronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitors

Higa, K. C., Goodspeed, A., Chavez, J. S., De Dominici, M., Danis, E., Zaberezhnyy, V., Rabe, J. L., Tenen, D. G., Pietras, E. M., & DeGregori, J. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20200560 · Cited by 57

Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification

Jorssen, J., Hulst, G. V., Mollers, K., Pujol, J., Petrellis, G., Baptista, A. P., Schetters, S. T. T., Baron, F., Caers, J., Lambrecht, B. N., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.027 · Cited by 63

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia

Lopez, C. K., Noguera, E., Stavropoulou, V., Robert, E., Aid, Z., Ballerini, P. F., Bilhou‐Nabera, C., Lapillonne, H., Boudia, F., Thirant, C., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1463 · Cited by 59

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration

Umemoto, T., Johansson, A., Ahmad, S. A. I., Hashimoto, M., Kubota, S., Kikuchi, K., Odaka, H., Era, T., Kurotaki, D., Sashida, G., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021109463 · Cited by 54

A specialized bone marrow microenvironment for fetal haematopoiesis

Liu, Y., Chen, Q., Jeong, H., Koh, B. I., Watson, E. C., Xu, C., Stehling, M., Zhou, B., & Adams, R. H. (2022) · Nature Communications · doi:10.1038/s41467-022-28775-x · Cited by 53

Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineage

Schippel, N., & Sharma, S. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.05.001 · Cited by 57

Network Approaches for Dissecting the Immune System

Shi, H., Yan, K., Ding, L., Qian, C., Chi, H., & Yu, J. (2020) · iScience · doi:10.1016/j.isci.2020.101354 · Cited by 51

Dental niche cells directly contribute to tooth reconstitution and morphogenesis

Hu, H., Duan, Y., Wang, K., Fu, H., Liao, Y., Wang, T., Zhang, Z., Kang, F., Zhang, B., Zhang, H., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111737 · Cited by 49

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells

Carrelha, J., Mazzi, S., Winroth, A., Hagemann-Jensen, M., Ziegenhain, C., Högstrand, K., Seki, M., Brennan, M. S., Lehander, M., Wu, B., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01845-6 · Cited by 53

The complexity of neutrophils in health and disease: Focus on cancer

Carnevale, S., Ghasemi, S., Rigatelli, A., & Jaillon, S. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101409 · Cited by 50

Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth

Hall, T., Kim, H., Dabbah, M., Myers, J., Crawford, J. C., Morales‐Hernández, A., Caprio, C., Sriram, P., Kooienga, E., Derecka, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33092-4 · Cited by 49

An iron rheostat controls hematopoietic stem cell fate

Kao, Y.-R., Chen, J., Kumari, R., Ng, A. K. Y., Zintiridou, A., Tatiparthy, M., Ma, Y., Aivalioti, M. M., Moulik, D., Sundaravel, S., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.01.011 · Cited by 50

Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis

Zhang, Y., Wang, S., Zhang, J., Liu, C., Li, X., Guo, W., Duan, Y.-J., Chen, X., Zong, S.-Y., Zheng, J., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-021-00814-7 · Cited by 49

Machine learning predicts putative hematopoietic stem cells within large single-cell transcriptomics data sets

Hamey, F., & Göttgens, B. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.08.009 · Cited by 48

Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation

Ding, P., Tan, Q., Wei, Z., Chen, Q., Wang, C., Qi, L., Wen, L., Zhang, C., & Yao, C. (2022) · Bone Research · doi:10.1038/s41413-022-00210-3 · Cited by 47

Dimensions of neutrophil life and fate

Hidalgo, A., & Casanova-Acebes, M. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101506 · Cited by 47

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

Kertser, A., Baruch, K., Deczkowska, A., Weiner, A., Croese, T., Kenigsbuch, M., Cooper, I., Tsoory, M., Ben-Hamo, S., Amit, I., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav4111 · Cited by 48

Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

Fukushima, T., Tanaka, Y., Hamey, F., Chang, C., Oki, T., Asada, S., Hayashi, Y., Fujino, T., Yonezawa, T., Takeda, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.061 · Cited by 45

High-resolution characterization of gene function using single-cell CRISPR tiling screen

Yang, L., Chan, A. K. N., Miyashita, K., Delaney, C. D., Wang, X., Li, H., Pokharel, S. P., Li, S., Li, M., Xu, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24324-0 · Cited by 45

Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

Nagahata, Y., Masuda, K., Nishimura, Y., Ikawa, T., Kawaoka, S., Kitawaki, T., Nannya, Y., Ogawa, S., Suga, H., Satou, Y., et al. (2022) · Blood · doi:10.1182/blood.2022016286 · Cited by 44

Charting the single-cell transcriptional landscape of haematopoiesis

Hamey, F. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.35245

The Single-Cell Transcriptional Landscape of Human Hematopoietic Progenitors

Loperfido, M., Pellin, D., Baricordi, C., Wolock, S. L., Klein, A. M., & Biasco, L. (2018) · Blood · doi:10.1182/blood-2018-99-116327

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors

Pellin, D., Loperfido, M., Baricordi, C., Wolock, S. L., Montepeloso, A., Weinberg, O. K., Biffi, A., Klein, A. M., & Biasco, L. (2019) · Nature Communications · doi:10.1038/s41467-019-10291-0 · Cited by 360

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

Paul, F., Arkin, Y., Giladi, A., Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.013 · Cited by 1,082

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic HierarchyPreprint

Sommarin, M. N. E., Dhapola, P., Safi, F., Warfvinge, R., Ulfsson, L. G., Erlandsson, E., Konturek-Cieśla, A., Thakur, R. K., Böiers, C., Bryder, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.01.437998 · Cited by 14