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Learning one’s genetic risk changes physiology independent of actual genetic risk

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Turnwald, Bradley P., Goyer, J. Parker, Boles, Danielle Z., Silder, Amy, Delp, Scott L., Crum, Alia J.·2018·Nature Human Behaviour

DOI 10.1038/s41562-018-0483-4PMC PMC6874306

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Abstract

Millions of people now access personal genetic risk estimates for diseases such as Alzheimer's, cancer and obesity 1. While this information can be informative 2-4, research on placebo and nocebo effects 5-8 suggests that learning of one's genetic risk may evoke physiological changes consistent with the expected risk profile. Here we tested whether merely learning of one's genetic risk for disease alters one's actual risk by making people more likely to exhibit the expected changes in gene-related physiology, behaviour and subjective experience. Individuals were genotyped for actual genetic risk and then randomly assigned to receive either a 'high-risk' or 'protected' genetic test result for obesity via cardiorespiratory exercise capacity (experiment 1, N = 116) or physiological satiety (experiment 2, N = 107) before engaging in a task in which genetic risk was salient. Merely receiving genetic risk information changed individuals' cardiorespiratory physiology, perceived exertion and running endurance during exercise, and changed satiety physiology and perceived fullness after food consumption in a self-fulfilling manner. Effects of perceived genetic risk on outcomes were sometimes greater than the effects associated with actual genetic risk. If simply conveying genetic risk information can alter actual risk, clinicians and ethicists should wrestle with appropriate thresholds for when revealing genetic risk is warranted.

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Authors: Turnwald, B. P., Goyer, J. P., Boles, D. Z., Silder, A., Delp, S. L., & Crum, A. J.
Affiliations: Stanford University (US)
Corresponding author: Turnwald, Bradley P.
ORCID: Turnwald, Bradley P.
Goyer, J. Parker
Boles, Danielle Z.
Silder, Amy
Delp, Scott L.
Crum, Alia J.
Venue: Nature Human Behaviour
Publisher: Springer Science and Business Media LLC
Published: 2018-12-10
Volume: 3
Issue: 1
Pages: 48-56
ISSN: 2397-3374 (ISSN-L)
DOI: 10.1038/s41562-018-0483-4
PMC: PMC6874306
OpenAlex: W2903243478
Cited by: 142
References: 63
Citations by year: 2026: 3 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 37 · 2021: 13 · 2020: 39 · 2019: 15 · 2018: 1
FWCI: 10.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Human Behaviour (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Science Foundation
National Institute of Biomedical Imaging and Bioengineering (U54EB020405)
National Center for Complementary and Integrative Health (DP2AT009511)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: genetic risk disclosure, self-fulfilling prophecy, placebo effect, nocebo effect, perceived exertion, running endurance, satiety, genetic testing
MeSH terms: Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Cardiorespiratory Fitness, Adult, Exercise Test, Physical Exertion, Female, Genetic Testing, Humans, Male, Obesity, Risk, Exercise Tolerance, Cyclic AMP Response Element-Binding Protein, Genetic Predisposition to Disease, Young Adult

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Learning one’s genetic risk changes physiology independent of actual genetic risk

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