The DOI matches its Crossref record; 265 of the 265 references it cites were found in a registry or an index.
Exploiting senescence for the treatment of cancer
Abstract
Senescence is a cellular response to a variety of stress signals that is characterized by a stable withdrawal from the cell cycle and major changes in cell morphology and physiology. While most research on senescence has been performed on non-cancer cells, it is evident that cancer cells can also mount a senescence response. In this Review, we discuss how senescence can be induced in cancer cells. We describe the distinctive features of senescent cancer cells and how these changes in cellular physiology might be exploited for the selective eradication of these cells (senolysis). We discuss activation of the host immune system as a particularly attractive way to clear senescent cancer cells. Finally, we consider the challenges and opportunities provided by a 'one-two punch' sequential treatment of cancer with pro-senescence therapy followed by senolytic therapy.
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In the citing paper
“Although numerous promising candidate senolytics are being identified, some of which have entered clinical trials 227 , prospective results of large- cohort oncology trials remain to be reported.”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [227]
In the citing paper
“Currently, Perturb-seq is performed on immortalized or cancer cell lines,129”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [129]
In the citing paper
“their clinical translation is hampered by limited specificity, resulting in on-target, off-tissue toxicities53.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [53]
In the citing paper
“Based on the preclinical experimental evidence enumerated here, approaches based on the induction of senescence in large fraction of tumors have the potential to enter the realm of the clinical practice, even more if combined with adjuvant immunotherapy or senolytic therapy to remove potentially harmful senescent escaper variants, as recently proposed.189,202,203”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [203]
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Cited by
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Metadata
- Authors
- Wang, L., Lankhorst, L., & Bernards, R.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Utrecht University (NL)
- Corresponding author
- Bernards, René
- Venue
- Nature Reviews Cancer
- Published
- 2022-03-03
- Volume
- 22
- Issue
- 6
- Pages
- 340-355
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W4221091893
- Cited by
- 867
- References
- 265
- Citations by year
- 2026: 161 · 2025: 237 · 2024: 254 · 2023: 141 · 2022: 73
- FWCI
- 24.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- cellular senescence, senolysis, senolytic therapy
- MeSH terms
- Cell Cycle, Humans, Neoplasms, Cellular Senescence
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