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Cited by 473

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

Open access
Ungvari, Zoltan, Tarantini, Stefano, Kiss, Tamas, Wren, Jonathan D., Giles, Cory B., Griffin, Courtney T., Murfee, Walter Lee, Pacher, Pal, Csiszar, Anna·2018·Nature Reviews Cardiology
DOI 10.1038/s41569-018-0030-z
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Abstract

Ageing is the main risk factor for the development of cardiovascular diseases. A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of endothelium-dependent dilator responses (endothelial dysfunction) associated with impairment of angiogenic processes and the subsequent pathological remodelling of the microcirculation contribute to compromised tissue perfusion and exacerbate functional decline in older individuals. This Review focuses on cellular, molecular, and functional changes that occur in the endothelium during ageing. We explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing. We also speculate on how these pathological processes could be therapeutically targeted. An improved understanding of endothelial biology in older patients is crucial for all cardiologists because maintenance of a competently functioning endothelium is critical for adequate tissue perfusion and long-term cardiac health.Cellular, molecular, and functional changes occur in the endothelium during ageing. Ungvari and colleagues explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing, and also speculate on how these pathological processes might be therapeutically targeted.Key pointsAge-related endothelial dysfunction associated with impairment of angiogenic processes and the subsequent pathological remodelling of the microcirculation contribute to compromised tissue perfusion and exacerbate functional decline in older individuals.The mechanisms underlying age-related endothelial dysfunction are multifaceted and are likely to involve increased oxidative and nitrative stress and alterations in the conserved molecular pathways affecting common ageing processes.Age-related impairment of angiogenesis probably results from reduced nitric oxide bioavailability, metabolic dysregulation, altered angiomiR expression, NRF2 dysfunction, endothelial senescence and apoptosis, alterations in anti-geronic circulating factors and inducers of angiogenesis, and impaired pericyte function.Anti-ageing interventions that prevent or reverse age-related endothelial dysfunction and improve angiogenesis are expected to confer cardiovascular protection and delay functional decline in older individuals, extending health span.

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Metadata

Authors
Ungvari, Z., Tarantini, S., Kiss, T., Wren, J. D., Giles, C. B., Griffin, C. T., Murfee, W. L., Pacher, P., & Csiszar, A.
Venue
Nature Reviews Cardiology
Publisher
Springer Science and Business Media LLC
Published
2018-05-24
Volume
15
Issue
9
Pages
555-565
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
DOI
10.1038/s41569-018-0030-z
OpenAlex
W2803815839
Cited by
473
References
21
FWCI
5.09
Type
journal article
Language
en
Open access
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