The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Circular RNAs open a new chapter in cardiovascular biology
Open accessAbstract
Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. In this Review, the authors discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.Key pointsCircular RNAs (circRNAs) are a large class of non-coding RNA molecules that form a covalently closed loop (unlike linear RNAs).circRNAs are produced from precursor mRNA back-splicing, a process catalysed by the spliceosome machinery.High-throughput sequencing has identified thousands of circRNAs in the human body, a great number of which are expressed in a tissue-specific or disease-specific manner.Although the biological functions of most circRNAs remain unknown, specific circRNAs have been shown to act as microRNA sponges, to interact with RNA-binding proteins, to regulate transcription or to be translated into proteins.Preliminary studies have provided evidence that individual circRNAs have critical regulatory functions in the cardiovascular system.Owing to their high stability and abundance in bodily fluids, circRNAs have potential as useful biomarkers for various diseases, including cardiovascular disease.
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1 retracted
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RetractedCircular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
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Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Exon-intron circular RNAs regulate transcription in the nucleus
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
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Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,702
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.027 · Cited by 2,423
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
RNA-based diagnostic and therapeutic strategies for cardiovascular disease
Lu, D., & Thum, T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0218-x · Cited by 331
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Xue, C., Li, G., Lu, J., & Li, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00788-w · Cited by 268
Chen, X., Jiang, C., Sun, R., Yang, D., & Liu, Q. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.01.010 · Cited by 66
Progress in circRNA-Targeted Therapy in Experimental Parkinson’s Disease
(2023) · doi:10.3390/pharmaceutics15082035 · Cited by 26
Metadata
- Authors
- Aufiero, S., Reckman, Y. J., Pinto, Y. M., & Creemers, E. E.
- Venue
- Nature Reviews Cardiology
- Published
- 2019-04-05
- Volume
- 16
- Issue
- 8
- Pages
- 503-514
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2934320411
- Cited by
- 357
- References
- 96
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- green
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