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Cited by 320Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancerColorectal Cancer Surgical Treatments

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Biomarker-guided therapy for colorectal cancer: strength in complexity

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Sveen, Anita, Kopetz, Scott, Lothe, Ragnhild A.·2020·Nature Reviews Clinical Oncology
DOI 10.1038/s41571-019-0241-1PMC PMC7577509
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Abstract

The number of molecularly stratified treatment options available to patients with colorectal cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide prognostication and treatment decision-making. The increase in both the number of biomarkers and their use has resulted in a progressively complex situation, evident both from the extensive interactions between biomarkers and from their sometimes complex associations with patient prognosis and treatment benefit. Current and emerging biomarkers also reflect the genomic complexity of CRC, and include a wide range of aberrations such as point mutations, amplifications, fusions and hypermutator phenotypes, in addition to global gene expression subtypes. In this Review, we provide an overview of current and emerging clinically relevant biomarkers and their role in the management of patients with CRC, illustrating the intricacies of biomarker interactions and the growing treatment opportunities created by the availability of comprehensive molecular profiling.

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Metadata

Authors
Sveen, A., Kopetz, S., & Lothe, R. A.
Affiliations
  • Oslo University Hospital (NO)
  • The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Sveen, Anita
ORCID
Venue
Nature Reviews Clinical Oncology
Publisher
Springer Science and Business Media LLC
Published
2019-07-09
Volume
17
Issue
1
Pages
11-32
ISSN
  • 1759-4774 (ISSN-L)
  • 1759-4782
DOI
10.1038/s41571-019-0241-1
PMC
PMC7577509
OpenAlex
W2957125530
Cited by
320
References
319
Citations by year
2026: 16 · 2025: 39 · 2024: 55 · 2023: 44 · 2022: 57 · 2021: 65 · 2020: 40 · 2019: 4
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (KL2TR000370)
  • National Cancer Institute (R01CA184843, P50CA221707, R01CA218230, R01CA187238, P30CA016672)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords
colorectal cancer, biomarkers, biomarker interaction, molecular stratification, targeted therapy, prognostic factors, molecular profiling, gene expression subtypes, hypermutator phenotype, gene amplification, gene fusion, point mutations, treatment decision-making
MeSH terms
Clinical Trials as Topic, Humans, Prognosis, Biomarkers, Tumor, Colorectal Neoplasms, Precision Medicine, Molecular Targeted Therapy, Molecular Medicine

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