Cited by 980Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsExtracellular vesicles in disease

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, Ronnie H., Gao, Weiwei, Zhang, Liangfang·2023·Nature Reviews Clinical Oncology

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Abstract

Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-specific nature, causing harm to non-malignant tissues. Over the past several decades, nanomedicine researchers have sought to address this challenge by developing nanoscale platforms capable of more precisely delivering drug payloads. Cell membrane-coated nanoparticles (CNPs) are an emerging class of nanocarriers that have demonstrated considerable promise for biomedical applications. Consisting of a synthetic nanoparticulate core camouflaged by a layer of naturally derived cell membranes, CNPs are adept at operating within complex biological environments; depending on the type of cell membrane utilized, the resulting biomimetic nanoformulation is conferred with several properties typically associated with the source cell, including improved biocompatibility, immune evasion and tumour targeting. In comparison with traditional functionalization approaches, cell membrane coating provides a streamlined method for creating multifunctional and multi-antigenic nanoparticles. In this Review, we discuss the history and development of CNPs as well as how these platforms have been used for cancer therapy. The application of CNPs for drug delivery, phototherapy and immunotherapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CNPs.

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Authors: Fang, R. H., Gao, W., & Zhang, L.
Affiliations: University of California San Diego (US)
Corresponding author: Zhang, Liangfang
ORCID: Fang, Ronnie H.
Gao, Weiwei
Zhang, Liangfang
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2022-10-28
Volume: 20
Issue: 1
Pages: 33-48
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/s41571-022-00699-x
OpenAlex: W4307475977
Semantic Scholar: aad18fe7d6405872bceb0dd4451cf81880d894d6
Cited by: 980
References: 162
Citations by year: 2026: 249 · 2025: 320 · 2024: 281 · 2023: 129 · 2022: 1
FWCI: 12.57
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA200574)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: cell membrane-coated nanoparticles, anticancer drug delivery, tumor targeting, biomimetic nanocarriers, immune evasion, phototherapy, cancer immunotherapy, nanoparticle biocompatibility
MeSH terms: Cell Membrane, Pharmaceutical Preparations, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles

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