Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

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Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy

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Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism

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Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy

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Metabolomic differentiation of benign vs malignant pulmonary nodules with high specificity via high-resolution mass spectrometry analysis of patient sera

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GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer

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Tryptophan metabolism is a physiological integrator regulating circadian rhythms

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Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

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Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease

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NAD + metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity

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Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway

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Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism

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Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

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Beneficial insights into postbiotics against colorectal cancer

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Cancer immunometabolism: advent, challenges, and perspective

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Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies

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Metabolomics and correlation network analysis of follicular fluid reveals associations between l ‐tryptophan, l ‐tyrosine and polycystic ovary syndrome

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Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy—Kynurenines Are Important Players

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Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints

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Tumor-associated neutrophils suppress CD8+ T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis

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The ups, downs and new trends of IDO1 inhibitors

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Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke

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DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota

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Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

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Fusobacterium nucleatum ‐Derived Outer Membrane Vesicles Promote Immunotherapy Resistance via Changes in Tryptophan Metabolism in Tumour‐Associated Macrophages

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Immune Checkpoint Inhibitors and Glioblastoma: A Review on Current State and Future Directions

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STAT3: A key signaling molecule for converting cold to hot tumors

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Diagnostic approach to thyroid cancer based on amino acid metabolomics in saliva by ultra-performance liquid chromatography with high resolution mass spectrometry

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Structure and Plasticity of Indoleamine 2,3-Dioxygenase 1 (IDO1)

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Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity

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Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine

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Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome

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Development of an Efficient and Sensitive Chemical Derivatization-Based LC–MS/MS Method for Quantifying Gut Microbiota-Derived Metabolites in Human Plasma and Its Application in Studying Cardiovascular Disease

Liao, H.-Y., Wang, C., Lee, C.-H., Kao, H., Wu, W., & Kuo, C. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00147 · Cited by 43

Effects of the food colorant carmoisine on zebrafish embryos at a wide range of concentrations

Kızıltan, T., Baran, A., Kankaynar, M., Şenol, O., Sulukan, E., Yıldırım, S., & Ceyhun, S. B. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03240-2 · Cited by 43

Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

Maganin, A. G. M., de Souza, G. R., Fonseca, M. M., Lopes, A. H., Guimarães, R. M., Dagostin, A., Cecílio, N. T., Mendes, A. S., Gonçalves, W. A., Silva, C. E. A., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153805 · Cited by 48

DeepInsight-3D architecture for anti-cancer drug response prediction with deep-learning on multi-omics

Sharma, A. K., Lysenko, A., Boroevich, K. A., & Tsunoda, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-29644-3 · Cited by 43

Mechanisms of microbiota-gut-brain axis communication in anxiety disorders

Jiang, M., Li, K., Wang, Y., Zhou, B., Li, H.-Y., Yan, Q., & Liu, Z.-G. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1501134 · Cited by 52

A Novel, Robust Method for Quantification of Multiple Kynurenine Pathway Metabolites in the Cerebrospinal Fluid

Schwieler, L., Trepci, A., Krzyżanowski, S., Hermansson, S., Granqvist, M., Piehl, F., Venckūnas, T., Brazaitis, M., Kamandulis, S., Lindqvist, D., et al. (2020) · Bioanalysis · doi:10.4155/bio-2019-0303 · Cited by 43

Tumor microenvironment, immune response and post-radiotherapy tumor clearance

Koukourakis, M. I., & Giatromanolaki, A. N. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02378-8 · Cited by 43

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

Mandarano, M., Bellezza, G., Belladonna, M. L., Vannucci, J., Gili, A., Ferri, I., Lupi, C., Ludovini, V., Falabella, G., Metro, G., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00839 · Cited by 45

Tryptophan Intake and Metabolism in Older Adults with Mood Disorders

Chojnacki, C. J., Popławski, T., Chojnacki, J., Fila, M., Konrad, P., & Błasiak, J. (2020) · Nutrients · doi:10.3390/nu12103183 · Cited by 42

Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications

Kasai, K., Nakano, M., Ohishi, M., Nakamura, T., & Miura, T. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11381-0 · Cited by 42

Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

Li, S. N., Wu, R., Wang, L., Kuo, H. D., Sargsyan, D., Zheng, X., Wang, Y., Su, X., & Kong, A. T. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23365 · Cited by 42

Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis

Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S. M., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.008 · Cited by 43

Latest developments in tryptophan metabolism: Understanding its role in B cell immunity

Dagenais-Lussier, X., Loucif, H., Beji, C., Telittchenko, R., Routy, J., & van Grevenynghe, J. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.02.003 · Cited by 43

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

McGinity, C. L., Palmieri, E. M., Somasundaram, V., Bhattacharyya, D. D., Ridnour, L. A., Cheng, R. Y. S., Ryan, A. E., Glynn, S. A., Thomas, D. D., Miranda, K. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137068 · Cited by 44

Highly Efficient versus Null Electrochemical Enantioselective Recognition Controlled by Achiral Colinkers in Homochiral Metal–Organic Frameworks

Huang, Y., Wang, Y., An, R., Gao, E., & Yue, Q. (2023) · ACS Sensors · doi:10.1021/acssensors.2c02320 · Cited by 41

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

He, K., Wang, Z., Luo, M., Li, B., Ding, N., Li, L., He, B., Wang, H., Cao, J., Huang, C., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04460-5 · Cited by 45

Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway

Stone, T. W., & Williams, R. O. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16015 · Cited by 45

Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease

Wang, Y., Wu, X., Shan, Q.-Y., Yang, Q., Yu, X.-Y., Yang, J., Miao, H., Cao, G., & Zhao, Y. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01598-4 · Cited by 42

Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery

Yan, X. C., Sanders, J. M., Gao, Y.-D., Tudor, M., Haidle, A. M., Klein, D. J., Converso, A., Lesburg, C. A., Zang, Y., & Wood, H. B. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00113 · Cited by 42

Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis

Joisten, N., Walzik, D., Metcalfe, A. J., Bloch, W., & Zimmer, P. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920938688 · Cited by 46

Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease

Baliga, M. M., Klawitter, J., Christians, U., Hopp, K., Chonchol, M., Gitomer, B. Y., Cadnapaphornchai, M. A., & Klawitter, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-84609-8 · Cited by 41

Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia

Huang, J., Tong, J., Zhang, P., Zhou, Y., Cui, Y., Tan, S., Wang, Z., Yang, F., Kochunov, P., Chiappelli, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01311-z · Cited by 44

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

Peyraud, F., Guégan, J., Bodet, D., Cousin, S., Bessede, A., & Italiano, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.807271 · Cited by 137

Role of tryptophan metabolism in cancers and therapeutic implications

Liu, X., & Zhai, X. (2021) · Biochimie · doi:10.1016/j.biochi.2021.01.005 · Cited by 73

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

Platten, M., Doeberitz, N. V. K., Oezen, I., Wick, W., & Ochs, K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00673 · Cited by 348

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy

Zhai, L., Spranger, S., Binder, D. C., Gritsina, G., Lauing, K. L., Giles, F. J., & Wainwright, D. A. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0420 · Cited by 327

Targeting the Broadly Pathogenic Kynurenine Pathway

(2015) · Thammasat University Digital Collections